Effect of Virtual Reality on Cognitive Dysfunction in Patients With Brain Tumor

Yang, Seoyon; Chun, Min Ho; Son, Yu Ri

doi:10.5535/arm.2014.38.6.726

Cited by 68 publications

(72 citation statements)

References 27 publications

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“…In a recent commentary, Ownsworth described some of the exciting recent psychosocial advancements in the management of primary brain tumors as well as future directions that take into account logistical barriers to providing face‐to‐face psychotherapy, such as tele‐health and family‐based support. Additionally, some of the most recent efforts toward supportive care interventions that may show promise at improving HRQoL in patients with brain tumors include a rehabilitation intervention of physical and occupational therapy, ketogenic diets, cranial electrotherapy stimulation, and virtual reality . All of these efforts provide hope for this growing field.…”

Section: Resultsmentioning

confidence: 99%

Patient‐reported health‐related quality of life outcomes in supportive‐care interventions for adults with brain tumors: A systematic review

et al. 2018

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Objectives The objectives of this systematic review were to (a) identify supportive‐care (psychosocial/behavioral, pharmacological, complementary, or alternative) interventions that have been evaluated via randomized controlled trials (RCTs) to improve patient‐reported health‐related quality of life (HRQoL) among adults with brain tumors, (b) evaluate the quality of the intervention studies, and (c) evaluate if developed interventions have been efficacious at improving HRQoL, as compared with control conditions in RCTs. Methods This systematic review was conducted using preferred reporting items for systematic reviews and meta‐analyses (PRISMA) guidelines. Four databases were searched for RCTs of supportive‐care interventions for adults with brain tumors, primary or metastatic, that included a patient‐reported HRQoL outcome. Quality of the included studies was assessed using the Effective Public Health Practice Project Quality Assessment Tool for Quantitative Studies. Results Ten RCTs involving 640 patients with either a primary or metastatic brain tumor investigating supportive‐care interventions with a HRQoL outcome were identified. In terms of quality, three of the studies received a “strong” rating, three received a “moderate” rating, and four of the studies received a “weak” rating. Only two of the interventions (ie, a home‐based psychosocial intervention and individualized acupuncture with standard rehabilitation) demonstrated improvements in HRQoL over control conditions. Conclusions HRQoL is of the utmost importance when treating patients with brain tumors. Yet there is a notable paucity of research to inform clinical decisions and evidence‐based practice. More high‐quality studies of interventions aimed at improving HRQoL are needed.

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Section: Resultsmentioning

confidence: 99%

Patient‐reported health‐related quality of life outcomes in supportive‐care interventions for adults with brain tumors: A systematic review

et al. 2018

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“…22 In three randomized studies the effect of cognitive rehabilitation to improve cognitive functioning was examined. [47][48][49] In one of these studies, virtual reality training was added to standard computer-based cognitive rehabilitation in 19 of 38 brain tumour patients and significantly improved several cognitive outcomes. 48 The largest randomized controlled study included 140 mainly low-grade glioma patients with both cognitive complaints and cognitive deficits.…”

Section: Cognitionmentioning

confidence: 99%

“…[47][48][49] In one of these studies, virtual reality training was added to standard computer-based cognitive rehabilitation in 19 of 38 brain tumour patients and significantly improved several cognitive outcomes. 48 The largest randomized controlled study included 140 mainly low-grade glioma patients with both cognitive complaints and cognitive deficits. 47 Immediately post-treatment evaluation showed significant subjective improvement in the intervention group, while at 6 months evaluation, the intervention group had significantly improved attention and verbal memory, as well as less mental fatigue.…”

Section: Cognitionmentioning

confidence: 99%

European Association for Neuro-Oncology (EANO) guidelines for palliative care in adults with glioma

Pace¹,

Dirven

Koekkoek

et al. 2017

The Lancet Oncology

231

184

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Patients with glioma present with complex palliative care needs throughout their disease trajectory. The life-limiting nature of gliomas and the presence of specific symptoms related to neurological deterioration necessitate an appropriate and early palliative care approach. The multidisciplinary palliative care task force of the European Association of Neuro-Oncology did a systematic review of the available scientific literature to formulate the best possible evidence-based recommendations for the palliative care of adult patients with glioma, with the aim to reduce symptom burden and improve the quality of life of patients and their caregivers, particularly in the end-of-life phase. When recommendations could not be made because of the scarcity of evidence, the task force either used evidence from studies of patients with systemic cancer or formulated expert opinion. Areas of palliative care that currently lack evidence and thus deserve attention for further research are fatigue, disorders of behaviour and mood, interventions for the needs of caregivers, and timing of advance care planning.

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“…The two cognitive retraining studies in adults with brain tumours both used computer programmes (Maschio, Dinapoli, Fabi, Giannarelli, & Cantelmi, 2015;Yang, Chun, & Son, 2014). In a pilot study, Maschio et al (2015) Gehring et al (2009) less from the cognitive rehabilitation programme (Gehring, Aaronson, Gundy, Taphoorn, & Sitskoorn, 2011) and evaluated its homework assignments as more burdensome than younger participants .…”

Section: Cognitive Retrainingmentioning

confidence: 99%

Interventions for cognitive problems in adults with brain cancer: A narrative review

et al. 2019

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Introduction Many patients with brain cancer experience cognitive problems. In this narrative review, we comprehensively evaluated empirical studies on various intervention approaches for cognitive problems in these patients. Methods Intervention studies that reported effects on cognitive functioning (either objectively tested or subjectively reported) in adult patients with primary and/or secondary brain tumours were identified through online searches in PubMed (MEDLINE) and Web of Science up to 13 March 2019. Results Of the 364 identified records, 10 pharmacological (including five randomised placebo‐controlled trials), 10 cognitive rehabilitation (including five [pilot] RCTs) and two multiple‐group exercise studies matched the inclusion criteria. Seventeen of 22 studies had final sample sizes smaller than 40. Several cognitive rehabilitation studies and some pharmacological approaches (donepezil and memantine) showed (at least partial) benefits for cognitive problems in adults with brain cancer. The effects of other pharmacological and exercise interventions were inconclusive and/or preliminary. Conclusion Overall, drawing firm conclusions is complicated due to various methodological shortcomings, including the absence of a (placebo) control group and small sample sizes. Promising effects have been reported for cognitive rehabilitation and some pharmacological approaches. Suggestions for more thorough research with respect to the various approaches are provided.

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Effect of Virtual Reality on Cognitive Dysfunction in Patients With Brain Tumor

Cited by 68 publications

References 27 publications

Patient‐reported health‐related quality of life outcomes in supportive‐care interventions for adults with brain tumors: A systematic review

Patient‐reported health‐related quality of life outcomes in supportive‐care interventions for adults with brain tumors: A systematic review

European Association for Neuro-Oncology (EANO) guidelines for palliative care in adults with glioma

Interventions for cognitive problems in adults with brain cancer: A narrative review

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