Effect of Viscum articulatum Burm. (Loranthaceae) in Nω-nitro-l-arginine methyl ester induced hypertension and renal dysfunction

Bachhav, Sagar S.; Bhutada, Mukesh S.; Patil, Savita D.; Baser, Bhavana; Chaudhari, Kishor B.

doi:10.1016/j.jep.2012.05.021

Cited by 21 publications

(23 citation statements)

References 27 publications

(44 reference statements)

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“…Mistletoe contains numerous bioactive compounds, including lectins, alkaloids, viscotoxins, and polysaccharides (Khwaja et al 1980(Khwaja et al , 1986Holtskog et al 1988), and their biological effects are known to be changed according to their preparation, host trees, and harvest times (Hulsen & Mechelke 1982;Park et al 1999). Previous reports showed the beneficial effects of mistletoe on blood cholesterol levels using methanol or ethanol mistletoe extracts (Avci et al 2006;Ferrero et al 2007;Bachhav et al 2012); however, an aqueous extract of mistletoe was used in this study. Thus, the different effects of mistletoe extracts on plasma cholesterol levels between our study and previous reports may be caused by different extract preparations which may lead to a different composition of bioactive compounds.…”

Section: Discussionmentioning

confidence: 94%

“…Methanol or ethanol extracts of mistletoe were reported to decrease total plasma cholesterol levels (Avci et al 2006;Ferrero et al 2007;Bachhav et al 2012) and increase HDL-C levels (Avci et al 2006;Ben et al 2006;Adaramoye et al 2012) in mice or rats. However, the effect of an aqueous extract of Korean mistletoe on the plasma levels of cholesterol and HDL-C was controversial (Kim 2006;Kim & Kim 2009).…”

Section: Kme Decreases Muscle Fatigue In Exercise-trained Micementioning

confidence: 99%

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The effects of Korean mistletoe extract on endurance during exercise in mice

Lee

Kim

et al. 2014

Animal Cells and Systems

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Many investigators have screened drugs and foods for the enhancement of endurance capacity and antifatigue. Mistletoe, a semiparasitic plant on various deciduous trees, has many known biological activities, including anticancer, anti-diabetes, antioxidant, and anti-cardiovascular disease effects. In a previous study, Korean mistletoe extract (KME) was reported to increase endurance capacity in mice. However, whether the administration of KME further enhances exercise performance, when combined with exercise training, was not investigated. In this study, we demonstrate that the administration of KME decreases the level of plasma lactate dehydrogenase, parameter of tissue damage and muscle fatigue when combined with exercise training. Exercise training increases the muscular glycogen and plasma free fatty acid (FFA) level, and KME administration in sedentary mouse group increases the plasma FFA level, indicating that KME administration alters the energy resources in muscle. In addition, KME administration enhances the exercise performance in sedentary mouse group, but did not further enhance exercise performance when combined with exercise training, suggesting that KME could be an excellent mimetic of exercise.

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Section: Discussionmentioning

confidence: 94%

Section: Kme Decreases Muscle Fatigue In Exercise-trained Micementioning

confidence: 99%

The effects of Korean mistletoe extract on endurance during exercise in mice

Lee

Kim

et al. 2014

Animal Cells and Systems

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“…Previous studies revealed that chronic oral administration of L -NAME alone (400 mg/l) can cause arterial hypertension and morphological abnormalities, such as moderate diffuse myocardial degeneration and necrosis with inflammatory infiltration in heart muscles [20,21,22]. Thus, L -NAME was added to the drinking water at dose of 100 mg/l in this study, which was chosen in order not to affect blood pressure or cardiac hypertrophy [13].…”

Section: Discussionmentioning

confidence: 99%

Nitric Oxide Synthase Inhibition Abolishes Exercise-Mediated Protection against Isoproterenol-Induced Cardiac Hypertrophy in Female Mice

Ren¹,

Yang²,

Tian³

et al. 2015

Cardiology

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Objective: Exercise training (ET) provides a cardioprotective effect against pathological cardiac hypertrophy. Nitric oxide (NO) plays an important role in modulating cardiac hypertrophy. However, few studies explore the relationship between NO signaling and the inhibitory effect of ET on pathological cardiac remodeling. Methods: In this study, we evaluated ET effects on isoproterenol (ISO)-induced cardiac hypertrophy in female mice. Moreover, L-NAME (N^ω-nitro-L-arginine methyl ester), a nonselective NO synthase (NOS) inhibitor, was used to assess the involvement of NO signaling in cardiac hypertrophy. Morphological and echocardiographic variables were assessed. Cardiac hypertrophy-related gene expression was detected by real-time PCR and the protein levels of NOS signaling molecules were determined by Western blot. Results:L-NAME treatment prevented the beneficial effects of ET against the increase in heart weight (HW)/body weight (BW), HW/tibia length and lung weight/BW and echocardiographic variables following ISO injection. Also, L-NAME co-administration reversed ET-induced inhibition of myocardial fibrosis and fetal gene reactivation in ISO-treated mice. Furthermore, L-NAME treatment prevented ET-mediated up-regulation of phosphorylated endothelial NOS and plasma NO in ISO-treated mice. Conclusions: Our findings demonstrate that L-NAME treatment could abolish ET-induced cardioprotection against pathological cardiac hypertrophy and that NOS modulation may be involved in the antihypertrophic effects induced by ET.

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“…visartiside A, visartiside B and eriodictyol 7-O-b-D-glucopyranoside, showed significant free radical scavenging activity with ED 50 values of 37.6, 34.1 and 63.3 lM, respectively. The study reported that these three flavanones possessed a 3 0 ,4 0 -dihydroxyphenyl group in the B-ring and suggested that [75][76][77]80,86] Antidiabetic, antituberculosis, diuretic, antitumour, cytoprotective, antioxidant, hepatoprotective, antihyperlipidaemic, antihypertension [78,[93][94][95][96][97][98] Betulinic acid N/A Anti-HIV, antibacterial, antimalarial, anti-inflammatory, anthelmintic, antinociceptive, anti-HSV-1, anticancer, antimalarial [97,99,100] Visartiside A Antioxidative, anti-inflammatory, cytotoxic [55] N/A Visartiside B Antioxidative, anti-inflammatory, cytotoxic [55] N/A Visartiside C Anti-inflammatory [55] N/A Visartiside D Anti-inflammatory [55] N/A Visartiside E Anti-inflammatory 55 N/A Visartiside F Anti-inflammatory [55] N/A Viscolin 4''-glucoside Anti-inflammatory…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…It was proposed that this antihypertensive effect of OA might be attributed to its diuretic, nephroprotective and antioxidant effects. [76,77] A study conducted in Dahl salt-sensitive (DSS), insulin-resistant rat model of genetic hypertension showed that OA, isolated from cloves, prevented the development of severe hypertension after six weeks of daily application (60 mg/kg b.w., i.p.). These antihypertensive effects were attributed to their potent diuretic-natriuretic-saluretic activity, direct cardiac effect, antihyperlipidaemic activity, antioxidant activity and hypoglycaemic activity.…”

Section: Antiulcer Activitymentioning

confidence: 99%

Viscum articulatum Burm. f.: a review on its phytochemistry, pharmacology and traditional uses

Patel

Singh

2018

Journal of Pharmacy and Pharmacology

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Objectives The aim of this study was to review and highlight traditional and ethnobotanical uses, phytochemical constituents, IP status, biological activity and pharmacological activity of Viscum articulatum. Methods Thorough literature searches were performed on Viscum articulatum, and data were analysed for reported traditional uses, pharmacological activity, phytochemicals present and patents filed. Scientific and patent databases such as PubMed, Science Direct, Google Scholar, Google patents, USPTO and Espacenet were searched using different keywords. Key findings Viscum articulatum has been traditionally used in different parts of the world for treatment of various ailments. Almost all the parts such as leaves, root, stem and bark are having medicinal values and are reported for their uses in Ayurvedic and Chinese system of medicine for the management of various diseases. Modern scientific studies demonstrate efficacy of this plant against hypertension, ulcer, epilepsy, inflammation, wound, nephrotoxicity, HIV, cancer, etc. Major bioactive phytochemicals include oleanolic acid, betulinic acid, eriodictyol, naringenin, b-amyrin acetate, visartisides, etc. Conclusions Side effects of allopathic medicines have created a global opportunity, acceptance and demand for phytomedicines. Viscum articulatum could be an excellent source of effective and safe phytomedicine for various ailments if focused translational efforts are undertaken by integrating the existing outcomes of researches.

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Effect of Viscum articulatum Burm. (Loranthaceae) in Nω-nitro-l-arginine methyl ester induced hypertension and renal dysfunction

Cited by 21 publications

References 27 publications

The effects of Korean mistletoe extract on endurance during exercise in mice

The effects of Korean mistletoe extract on endurance during exercise in mice

Nitric Oxide Synthase Inhibition Abolishes Exercise-Mediated Protection against Isoproterenol-Induced Cardiac Hypertrophy in Female Mice

Viscum articulatum Burm. f.: a review on its phytochemistry, pharmacology and traditional uses

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