Effect of Visfatin on Blood Pressure in Normal and DOCA-Salt Hypertensive Rats

Rezk, Mohamad Yosof; Saad, Adel; Alantary, Ahmed K

doi:10.5958/2320-608x.2014.00012.2

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“…In a study on male albino rats we 53 found that visfatin has insignificant inhibitory effect on blood pressure in normal rats. We found also that visfatin (1 nM) produced insignificant inhibitory effect on systolic and diastolic pressures in DOCA salt treated rats.…”

Section: -Visfatin and Hypertensionmentioning

confidence: 89%

Visfatin and Cardiovascular Protection

Rezk¹

2014

J. Drug Delivery Ther.

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Visfatin, also named nicotinamide phosphoribosyl transferase (NAMPT), is an adipokinehas been shown to possess anti-diabetic 1 , anti-tumor 2 , and pro-inflammatory properties 3 .Visfatin expression is increased in animal models of obesity and its plasma concentrations are increased in humans with abdominal obesity or type 2 diabetes mellitus 4,5.Visfatin can regulate immune action and is involved in the NAD+ salvage pathway 6 .It is well established that adipocytes have a more complex physiological role 7 and because blood vessels express receptors for most of the adipocyte-derived factors, adipose tissue seems to play a key role in cardiovascular physiology via the existence of a network of local and systemic signals 8 .The relationship between cardiovascular diseases (CVD), obesity and metabolic syndrome was also supported by Gauvreau et al 9 who mentioned that metabolic syndrome is characterized by changes in arterial blood pressure, glucose metabolism, lipid and lipoprotein profiles in addition to inflammation. They also reported that intra-abdominal (visceral) adipose tissue in particular, rather than peripheral, appears to be associated with global cardiometabolic risk.Visfatin may be related to the development of obesity-related diseases such as diabetes mellitus and cardiovascular disease 10 . This suggestion was supported byDe Clercq et al 11 who reported that adipocytes produce large numbers of hormones, peptides, and other molecules that affect cardiovascular function, not only in an endocrine manner, but also by autocrine and paracrine mechanisms. In this review we summarized the main aspects of visfatin in cardiovascular diseases but first we discussed the relationship between visfatin and serum lipids because of the definite role of lipids in different cardiovascular diseases.

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Section: -Visfatin and Hypertensionmentioning

confidence: 89%