Effect of Vitamin B&lt;sub&gt;6&lt;/sub&gt; and B&lt;sub&gt;1&lt;/sub&gt; Deficiencies on the Intestinal Uptake of Calcium, Zinc and Cadmium

Prasad, R.; Lyall, Vijay; Nath, R.

doi:10.1159/000176581

Cited by 12 publications

(2 citation statements)

References 19 publications

(25 reference statements)

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“…Prasad et al [27] reported increased intestinal uptake of calcium in vitamin B6 deficiency, possibly due to a change in the brush border, allowing more absorption. Another cause of nephrolithiasis in pyridoxine deficiency is increased intestinal absorption of both endogenous and exogenous oxalate [28,29].…”

Section: Discussionmentioning

confidence: 99%

Growth and development in rats and deficiency of magnesium and pyridoxine.

Kubena

Edgar

Veltmann

1988

Journal of the American College of Nutrition

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Eight-eight female weanling Sprague-Dawley rats were fed diets containing either 650 or 150 mg magnesium/kg diet and 7.0 or 3.5 mg pyridoxine-HCl/kg diet, in a 2 x 2 factorial arrangement, during growth, gestation, and lactation. The objective of the study was to determine whether concurrent dietary deficiencies of magnesium and pyridoxine were synergistic, additive, or antagonistic with regards to effects on reproductive performance, growth, and development of offspring, and tissue content of magnesium and calcium. Body weight of dams and pups was not different between groups until day 9 of lactation, at which point those animals in either low magnesium group weighed less than the other. Litter size and birth weight were not different. Development, as measured by timing of unfolding of the external ear, opening of both eyes, and clinical emergence of incisors, was delayed in pups from litters in the low magnesium groups. A synergistic effect on delay of onset of ear unfolding by deficiency of both magnesium and pyridoxine was observed. Calcium content of heart and kidney from dams was increased in the low magnesium groups. Renal calcium was not further increased by the level of pyridoxine deficiency in this study. The calcium to magnesium ratio in heart from pups was higher in those from litters in the low magnesium and pyridoxine group than in the others. Results indicate that simultaneous deficiencies of magnesium and pyridoxine may impair function synergistically. Because these two nutrients are often reported to be presented in inadequate amounts in diets of women in their reproductive years, the potential exists for impaired reproductive success.

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Section: Discussionmentioning

confidence: 99%

Growth and development in rats and deficiency of magnesium and pyridoxine.

Kubena

Edgar

Veltmann

1988

Journal of the American College of Nutrition

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“…These minerals also act as cofactors of antioxidant enzymes; therefore, they can reduce the cadmium-induced oxidative stress via antioxidant enzymatic activity (Koekkoek and van Zanten, 2016). Studies have shown that a deficiency of vitamin B1 and B6 increased susceptibility to cadmium toxicity (Prasad et al, 1982). Hence, supplementation with these vitamins is a suggested method for providing protection against cadmium-induced toxicity.…”

Section: Introductionmentioning

confidence: 99%

Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts

Batool¹,

Agha²,

Tabassum³

et al. 2019

Acta Neurobiologiae Experimentalis

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Cadmium, a heavy metal with no physiological function in the human body, is considered a bio-hazard. It is also considered to be a potent neurotoxin. The primary sources of cadmium exposure are diet and cigarette smoke. It has been postulated that nutritional deficiencies can increase the risk of cadmium toxicity. Nuts provide essential nutrients which are necessary for the maintenance of brain health in humans. The present study was designed to investigate the possible protective effects of almond and walnut supplementation on cadmium-induced neurotoxicity. Cadmium was orally administered at a dose of 50 mg/kg weekly with or without the supplementation of almond and walnut in rats. Intensities of depression-and anxiety-related behaviors were assessed by the forced swim test and light/dark transition test, respectively. Memory function was also evaluated by the elevated plus maze, Morris water maze and novel object recognition task. After four weeks of treatment it was observed that cadmium administration significantly induced depressogenic and anxiogenic behaviors. Memory function was also impaired by cadmium administration. Cadmium-treated rats exhibited reduced noradrenalin, dopamine and serotonin levels in the brain, whereas the levels of their respective metabolites were significantly increased. The dietary supplementation of almond and walnut at a dose of 400 mg/kg/day significantly attenuated cadmium-induced depression, anxiety and memory impairments. Neurochemical aberrations also normalized following supplementation with these nuts in rats. The present study demonstrates that long-term supplementation with almond and walnut provides essential nutrients which may overcome nutritional deficiencies and thereby reduce heavy-metal intoxication.

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Bioavailability oF Trace Elements in Foodstuffs and Beverages

McKenzie

1984

Changing Metal Cycles and Human Health

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Effect of Vitamin B<sub>6</sub> and B<sub>1</sub> Deficiencies on the Intestinal Uptake of Calcium, Zinc and Cadmium

Cited by 12 publications

References 19 publications

Growth and development in rats and deficiency of magnesium and pyridoxine.

Growth and development in rats and deficiency of magnesium and pyridoxine.

Prevention of cadmium-induced neurotoxicity in rats by essential nutrients present in nuts

Bioavailability oF Trace Elements in Foodstuffs and Beverages

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