Effect of Vitamin C on Antioxidants, Lipid Peroxidation, and GSH System in the Normal Guinea Pig Heart.

Rojas, C.; Cadenas, Susana; Pérez‐Campo, R.; López-Torres, Mónica; Barja, Gustavo

doi:10.3177/jnsv.40.411

Cited by 22 publications

(8 citation statements)

References 28 publications

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“…Excessive alcohol consumption leads to deficiency of anti-oxidants like vitamin C and reduced glutathione (Gerster, 1995) and this could be the reason for low levels of these anti-oxidants in liver and plasma of AC. Vitamin C has the ability to sequester the singlet oxygen radical, stabilize the hydroxyl radical and thus halt peroxidation of cellular lipid membranes (Rojas, 1994). In the present study also, levels of vitamin C were maintained high in all experimental groups.…”

Section: Discussionsupporting

confidence: 67%

Effects of methanol extract of bark of <i>Bauhinea purpurea</i> on alcohol-induced liver toxicity in albino rats

Padmaja¹

2011

International Journal of Biological and Chemical Sciences

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The present study has been aimed to evaluate the protective potential of methanol bark extract of Bauhinia purpurea (MBP) in albino rats against alcohol-induced hepatotoxicity. Rats were randomly divided into four groups; alcohol control group (AC) receiving alcohol (5 g/kg), normal control group (NC) that received distilled water, and two experimental groups (E1 and E2) that were administered two doses of methanol extract (50 and 100 mg/kg body weight) for 30 days. At the end of the experiment, rats were killed after ether anesthesia and liver and blood were collected for biochemical measurements. Parameters measured were thiobarbituric acid reactive substances (TBARS), serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, reduced glutathione, glutathione peroxidase, superoxide dismutase, catalase and ascorbic acid. Methanol extract inhibited lipid peroxidation as indicated low levels of thiobarbituric acid. Low levels in the activities of serum aspartate aminotransferase (AST) and serum alanine aminotransferase (ALT) in experimental animals demonstrated the protective effects of MBP from hepatic toxicity. It also maintained the levels of enzymatic and non-enzymatic antioxidants in dose dependant manner.

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Section: Discussionsupporting

confidence: 67%

Effects of methanol extract of bark of <i>Bauhinea purpurea</i> on alcohol-induced liver toxicity in albino rats

Padmaja¹

2011

International Journal of Biological and Chemical Sciences

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“…Moreover, there was a significant increase in GPx activity in RBC and plasma [147]. Similarly, heart GPx and GSSG levels increased after 5 weeks of high ascorbate supplementation in guinea pigs [148]. Investigators attributed these negative results to peroxidative stress induced by the high ascorbate doses [147].…”

Section: Effects Of Micronutrient Supplementationmentioning

confidence: 99%

Impact of Supplementary Amino Acids, Micronutrients, and Overall Diet on Glutathione Homeostasis

Gould

Pazdro

2019

Nutrients

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Glutathione (GSH) is a critical endogenous antioxidant found in all eukaryotic cells. Higher GSH concentrations protect against cellular damage, tissue degeneration, and disease progression in various models, so there is considerable interest in developing interventions that augment GSH biosynthesis. Oral GSH supplementation is not the most efficient option due to the enzymatic degradation of ingested GSH within the intestine by γ-glutamyltransferase, but supplementation of its component amino acids—cysteine, glycine, and glutamate—enhances tissue GSH synthesis. Furthermore, supplementation with some non-precursor amino acids and micronutrients appears to influence the redox status of GSH and related antioxidants, such as vitamins C and E, lowering systemic oxidative stress and slowing the rate of tissue deterioration. In this review, the effects of oral supplementation of amino acids and micronutrients on GSH metabolism are evaluated. And since specific dietary patterns and diets are being prescribed as first-line therapeutics for conditions such as hypertension and diabetes, the impact of overall diets on GSH homeostasis is also assessed.

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“…Vitamin C has a protective effect on lipid peroxidation 1 and improves lipid metabolism, such as lipolysis, by participating in carnitine synthesis 2,3 . Dietary ascorbic acid also influences plasma lipid levels in rainbow trout 4 .…”

Section: Introductionmentioning

confidence: 99%

Effect of dietary vitamins C and E fortification on lipid metabolism in red sea bream Pagrus major and black sea bream Acanthopagrus schlegeli

et al. 2003

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To determine the effect of vitamins C and E on lipid metabolism and interactions between them, L‐ascorbyl‐2‐monophosphate‐Mg (APM) and α‐tocopherol acetate (TA) were fortified to a commercially based diet and fed to 0‐year red sea bream Pagrus major and 1‐year black sea bream Acanthopagrus schlegeli. Fortification of APM and TA, respectively, increased ascorbate (ASC) and α‐tocopherol (α‐Toc) contents in the organs. In addition, APM fortification increased α‐Toc accumulation in both fishes, although TA fortification did not significantly affect the ASC content. Fortification of APM caused a depression in lipid accumulation in the intraperitoneal fat body and liver in red sea bream. Furthermore, a decrease in the serum thiobarbituric acid value in black sea bream and a reduction of the adipocyte diameter in the APM‐fortified groups of both fishes were observed. However, fortification of TA did not affect these parameters as significantly as did fortification of APM. The shortest recovery time to air‐dipping was found in the APM + TA‐fortified group, followed by the APM‐fortified group in red sea bream. The results implied an effect of vitamin C on lipid metabolism, and acceleration of vitamin E absorption and/or suppression of vitamin E degradation.

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Effect of Vitamin C on Antioxidants, Lipid Peroxidation, and GSH System in the Normal Guinea Pig Heart.

Cited by 22 publications

References 28 publications

Effects of methanol extract of bark of <i>Bauhinea purpurea</i> on alcohol-induced liver toxicity in albino rats

Effects of methanol extract of bark of <i>Bauhinea purpurea</i> on alcohol-induced liver toxicity in albino rats

Impact of Supplementary Amino Acids, Micronutrients, and Overall Diet on Glutathione Homeostasis

Effect of dietary vitamins C and E fortification on lipid metabolism in red sea bream Pagrus major and black sea bream Acanthopagrus schlegeli

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