Effect of Vitamin C on Glutathione Peroxidase Activities in Pregnant Nigerian Women - An Ilorin Study

Olayaki, LA; Jimoh, AA; Salman, TM; Olumeyan, CI; Soladoye, AO

doi:10.4314/nmp.v53i1-2.28919

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“…22 The free radical scavenging power of the micro-alga could be attributed to improved reproductive outcomes because of the reduction in the accumulated malondialdehyde observed in the supplemented group which was also similar to reports of of some researchers which described malondialdehyde as a compound of reproduction risk because of its negative effect on gestation. 23 Therefore, the reduction of this compound in the supplemented group of this study suggests that Chlorella vulgaris intakes due to its antioxidant properties could serve as a health promoter during the gestation period. Similar finding was also reported in an earlier study which suggested that reduced lipid peroxidation in pregnant rats could be associated with better gestational outcomes.…”

Section: Discussionmentioning

confidence: 65%

Dietary Chlorella vulgaris Supplementation Improves Reproductive Index of Female Rabbits and Protect their Progeny against Oxidative Stress

et al. 2022

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Background: Oxidative stress negatively impacts pregnancy and its outcomes; hence, its avoidance through gestational antioxidant intakes is a desired nutrition-reproduction practices. Materials and Methods: Female rabbits (n=40) were divided into 5 groups and supplemented with 0, 200, 300, 400, and 500 mg Chlorella vulgaris biomass per kilogram body weight daily, respectively throughout the gestation period. Upon kindling, kits of the female rabbits (n=75) were randomly selected and monitored from birth till 120 days old. The reproductive performance of the female rabbits was evaluated by computation of their reproductive index, while birth weight, growth rate, oestrogen and testosterone concentrations, oxidative stress biomarkers, and expression of selected functional genes of the progeny were determined. Results:The gestational intake of Chlorella vulgaris increased reproductive index of the female rabbits (p < 0.05), and it also increases the growth and oxidative stress protection status of the rabbit progeny (p < 0.05). Selected functional genes, including Gstp1, Cyp1a1, Ar, Ghr, Il2, and Il6 assessed in the progeny of the supplemented groups were significantly upregulated (p < 0.05). Conclusion: It was concluded from these results that gestational Chlorella vulgaris biomass intake improved reproductive index of the female rabbits, increased growth and oxidative stress protection in their progeny.

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Section: Discussionmentioning

confidence: 65%