Effect of vitamin C on glycosylation of proteins

Davie, Sarah J; Gould, Barry J.; Yudkin, John

doi:10.2337/diabetes.41.2.167

Cited by 128 publications

(27 citation statements)

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“…These findings are also consistent with earlier reports in adults, suggesting that vitamin C supplementation is associated with reduced Type 2 diabetes risk [24]. The reason for the anomalous positive association between plasma vitamin C and HbA 1c in the present study remains unclear, but could reflect an effect of circulating vitamin C levels on glycation of haemoglobin, as previously reported [25]. The ethnic differences in plasma vitamin C reported in the present study are consistent with a previous study in adults, which showed that South-Asian adults had lower plasma vitamin C than white Europeans, a difference which was not explained by differences in vitamin supplement use [9].…”

Section: Discussionsupporting

confidence: 94%

Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross‐sectional associations with insulin resistance and glycaemia in 9–10 year‐old children

et al. 2015

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AimTo examine whether low circulating vitamin C concentrations and low fruit and vegetable intakes were associated with insulin resistance and other Type 2 diabetes risk markers in childhood.MethodsWe conducted a cross‐sectional, school‐based study in 2025 UK children aged 9–10 years, predominantly of white European, South‐Asian and black African origin. A 24‐h dietary recall was used to assess fruit, vegetable and vitamin C intakes. Height, weight and fat mass were measured and a fasting blood sample collected to measure plasma vitamin C concentrations and Type 2 diabetes risk markers.ResultsIn analyses adjusting for confounding variables (including socio‐economic status), a one interquartile range higher plasma vitamin C concentration (30.9 μmol/l) was associated with a 9.6% (95% CI 6.5, 12.6%) lower homeostatic model assessment of insulin resistance value, 0.8% (95% CI 0.4, 1.2%) lower fasting glucose, 4.5% (95% CI 3.2, 5.9%) lower urate and 2.2% (95% CI 0.9, 3.4%) higher HDL cholesterol. HbA1c concentration was 0.6% (95% CI 0.2, 1.0%) higher. Dietary fruit, vegetable and total vitamin C intakes were not associated with any Type 2 diabetes risk markers. Lower plasma vitamin C concentrations in South‐Asian and black African‐Caribbean children could partly explain their higher insulin resistance.ConclusionsLower plasma vitamin C concentrations are associated with insulin resistance and could partly explain ethnic differences in insulin resistance. Experimental studies are needed to establish whether increasing plasma vitamin C can help prevent Type 2 diabetes at an early stage.

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Section: Discussionsupporting

confidence: 94%

Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross‐sectional associations with insulin resistance and glycaemia in 9–10 year‐old children

et al. 2015

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“…[19][20][21] Vitamins C and E have been demonstrated to lower HbA1c levels, possibly by inhibiting glycation. 22,23 There is also a higher risk of misdiagnosis in patients with end-stage renal disease and alcohol consumption. 24,25 Finally, HbA1c testing might be biased due to the interference from several haemoglobin variants that may induce a higher measurement imprecision.…”

Section: Diabetes Mellitus and Cardiovascular Diseasesmentioning

confidence: 99%

Glycemic variability in the development of cardiovascular complications in diabetes

Nusca

Tuccinardi

Albano

et al. 2018

Diabetes Metabolism Res

125

114

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Diabetes mellitus represents a major risk factor for the development of coronary artery disease and other vascular complications. Glycated haemoglobin, fructosamine, and fasting blood glucose levels are partial parameters to exhaustively describe patient dysglycemic status. Thus, recently the new concept of glycemic variability has emerged, including information about two major aspects: the magnitude of blood glucose excursions (from nadir to peak, thus lower and higher spikes) and the time intervals in which these fluctuations occur. Despite the lack of consensus regarding the most appropriate definition and tools for its assessment, glycemic variability seems to have more deleterious effects than sustained hyperglycemia in the pathogenesis of diabetic cardiovascular complications. This manuscript aimed to review the most recent evidence on glycemic variability and its potential use in everyday clinical practice to identify diabetic patients at higher risk of cardiovascular complications and thus needing stricter monitoring and treatment.

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“…34 It has been reported that chronic ingestion of aspirin and high doses of vitamin C and E, as well as other antioxidants, can lead to inhibition of hemoglobin glycation, thereby lowering A 1c , although the degree to which this occurs clinically is debated. [42][43][44][45] Recent reports on Hb glycation in chronic renal failure indicate that lipid peroxidation of Hb may increase glycation. 46 The relationship between chronic renal failure and A 1c is complex: patients with chronic renal failure have decreased levels of erythropoietin, potentially increased glycation, higher levels of carbamylated Hb, and variable exposure to exogenous glucose through dialysate fluid, which could elevate A 1c , whereas decreased erythrocyte lifespan would lower A 1c .…”

Section: Glycated Hemoglobinmentioning

confidence: 99%

Review of hemoglobin A_1c in the management of diabetes

Gallagher

Roith

Bloomgarden

2009

Journal of Diabetes

283

232

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Hemoglobin HbA1c (A1c) has been used clinically since the 1980s as a test of glycemic control in individuals with diabetes. The Diabetes Control and Complications Trial (DCCT) demonstrated that tight glycemic control, quantified by lower blood glucose and A1c levels, reduced the risk of the development of complications from diabetes. Subsequently, standardization of A1c measurement was introduced in different countries to ensure accuracy in A1c results. Recently, the International Federation of Clinical Chemists (IFCC) introduced a more precise measurement of A1c, which has gained international acceptance. However, if the IFCC A1c result is expressed as a percentage, it is lower than the current DCCT‐aligned A1c result, which may lead to confusion and deterioration in diabetic control. Alternative methods of reporting have been proposed, including A1c‐derived average glucose (ADAG), which derives an average glucose from the A1c result. Herein, we review A1c, the components involved in A1c formation, and the interindividual and assay variations that can lead to differences in A1c results, despite comparable glycemic control. We discuss the proposed introduction of ADAG as a surrogate for A1c reporting, review imprecisions that may result, and suggest alternative clinical approaches.

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Effect of vitamin C on glycosylation of proteins

Cited by 128 publications

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Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross‐sectional associations with insulin resistance and glycaemia in 9–10 year‐old children

Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross‐sectional associations with insulin resistance and glycaemia in 9–10 year‐old children

Glycemic variability in the development of cardiovascular complications in diabetes

Review of hemoglobin A_1c in the management of diabetes

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Effect of vitamin C on glycosylation of proteins

Cited by 128 publications

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Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross‐sectional associations with insulin resistance and glycaemia in 9–10 year‐old children

Fruit, vegetable and vitamin C intakes and plasma vitamin C: cross‐sectional associations with insulin resistance and glycaemia in 9–10 year‐old children

Glycemic variability in the development of cardiovascular complications in diabetes

Review of hemoglobin A1c in the management of diabetes

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Review of hemoglobin A_1c in the management of diabetes