Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia

Alahmar, Ahmed T

doi:10.5005/jp-journals-10016-1147

Cited by 22 publications

(11 citation statements)

References 26 publications

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“…The sperm parameters that improved were motility, sperm count, and nuclear vacuolization [ 71 ]. These findings are congruent with those of our recent study that demonstrated that daily supplementation with vitamin C (90 mg/day), vitamin E (15 mg/day), CoQ10 (4 mg/day), selenium (30 µg/day), and zinc (5 mg/day) for 3 months improved sperm concentration, progressive motility, and total motility in men with idiopathic oligoasthenozoospermia [ 72 ].…”

Section: Combination Of Oral Antioxidantssupporting

confidence: 92%

The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia

Alahmar

2018

Clin Exp Reprod Med

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It has been estimated that approximately 15% of reproductive-age couples suffer from infertility. Male factors contribute to almost half of infertility cases, and in many patients the underlying cause of oligoasthenoteratozoospermia is unknown. Accumulating evidence suggests that oxidative stress plays a role as a contributing factor to male infertility, and reactive oxygen species have been shown to impair sperm function and motility and to damage sperm membrane and DNA. Therefore, this review explored the evidence provided by studies published from 2002 to 2017 on the impact of oral antioxidants (vitamin C, vitamin E, L-carnitine, coenzyme Q10, zinc, selenium, and pentoxifylline) on seminal fluid parameters in men with idiopathic oligoasthenoteratozoospermia. Most of the studies were randomized controlled studies that investigated the effect of single or combined antioxidants and reported improvements in at least one semen parameter. The most noteworthy effect that was found was that the use of multiple antioxidants increased sperm motility and concentration. Nonetheless, there is a lack of agreement on the dose, the duration of treatment, and whether individual or combined oral antioxidants should be used. Therefore, the current review provides evidence supporting the use of oral antioxidants in the treatment of infertile men with idiopathic oligoasthenoteratozoospermia.

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Section: Combination Of Oral Antioxidantssupporting

confidence: 92%

The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia

Alahmar

2018

Clin Exp Reprod Med

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“…A body of literature has demonstrated beneficial effects of CoQ10 and other antioxidants on semen parameters. However, there is a lack of agreement on the type and the use of individual or combination antioxidant therapy [18,30]. A recent meta-analysis also showed that doses of CoQ10 varied (200–300 mg/day) [15].…”

Section: Discussionmentioning

confidence: 99%

The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia

Alahmar¹

2019

Clin Exp Reprod Med

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Objective: Oxidative stress contributes to male infertility, and antioxidants have been recommended for treating idiopathic oligoasthenoteratozoospermia (OAT). There is, however, a lack of agreement on the type, dosing, and use of individual antioxidants or combinations thereof. The purpose of this study was to compare the effects of two doses of coenzyme Q10 (CoQ10) on semen parameters and antioxidant status in men with idiopathic OAT. Methods: In this prospective study, patients with idiopathic OAT received 200 mg/day (n = 35) or 400 mg/day (n = 30) of CoQ10 orally for 3 months. All patients underwent semen analysis according to the fifth editions of the World Health Organization criteria. Total antioxidant capacity (TAC), catalase (CAT) activity, and superoxide dismutase (SOD) activity were measured both before and after treatment. Results: Treatment with CoQ10 (200 mg/day or 400 mg/day) resulted in a significant increase in sperm concentration from baseline (8.22 ±6.88 to 12.53 ±8.11 million/mL, p =0.019; 7.58 ±5.41 to 12.33 ±6.1 million/mL, p =0.002, respectively), progressive motility (16.54% ±9.26% to 22.58% ±10.15%, p =0.011; 14.22% ±12.85% to 26.1% ±14.52%, p =0.001, respectively), and total motility (25.68% ± 6.41% to 29.96% ± 8.09%, p = 0.016; 23.46% ± 12.59% to 34.82% ± 14.17%, p = 0.001, respectively). CoQ10 therapy also increased TAC (p= 0.009, p= 0.001, respectively), SOD activity (p= 0.004, p= 0.001, respectively), and CAT activity (p= 0.039, p= 0.024, respectively). Furthermore, antioxidant measures correlated significantly with seminal fluid parameters (r = 0.36-0.76). Conclusion: CoQ10 supplementation improved semen parameters and antioxidant status in men with idiopathic OAT, with a greater improvement shown in men who took 400 mg/day than in those who took 200 mg/day.

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“…(MedCalc Software bv, Ostend, Belgium). Chi-square test was used to evaluate the association between the quality of the study and the outcomes (positive or no/negative effect) due to antioxidant treatment on semen parameters and sperm function such as oxidative stress and SDF are presented in Table 2 [ 25 26 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 …”

Section: Methodsmentioning

confidence: 99%

Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence

Agarwal

Leisegang

Majzoub

et al. 2021

World J Mens Health

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It is widely accepted that oxidative stress plays an important role in the pathophysiology of male infertility and that antioxidants could have a significant role in the treatment of male infertility. The main objectives of this study are: 1) to systematically review the current evidence for the utility of antioxidants in the treatment of male infertility; and 2) propose evidence-based clinical guidelines for the use of antioxidants in the treatment of male infertility. A systematic review of the available clinical evidence was performed, with articles published on Scopus being manually screened. Data extracted included the type of antioxidant used, the clinical conditions under investigation, the evaluation of semen parameters and reproductive outcomes. The adherence to the Cambridge Quality Checklist, Cochrane Risk of Bias for randomized controlled trials (RCTs), CONSORT guidelines and JADAD score were analyzed for each included study. Further, we provided a Strength Weakness Opportunity Threat (SWOT) analysis to analyze the current and future value of antioxidants in male infertility. Of the 1,978 articles identified, 97 articles were included in the study. Of these, 52 (53.6%) were uncontrolled (open label), 12 (12.4%) unblinded RCTs, and 33 (34.0%) blinded RCTs, whereas 44 (45.4%) articles tested individual antioxidants, 31 (32.0%) a combination of several products in variable dosages, and 22 (22.6%) registered antioxidant products. Based on the published evidence, we 1) critically examined the necessity of additional double-blind, randomized, placebo-controlled trials, and 2) proposed updated evidence-based clinical guidelines for antioxidant therapy in male infertility. The current systematic review on antioxidants and male infertility clearly shows that antioxidant supplementation improves semen parameters. In addition, it provides the indications for antioxidant treatment in specific clinical conditions, including varicocele, unexplained and idiopathic male infertility, as well as in cases of altered semen quality.

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Effect of Vitamin C, Vitamin E, Zinc, Selenium, and Coenzyme Q10 in Infertile Men with Idiopathic Oligoasthenozoospermia

Cited by 22 publications

References 26 publications

The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia

The effects of oral antioxidants on the semen of men with idiopathic oligoasthenoteratozoospermia

The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia

Utility of Antioxidants in the Treatment of Male Infertility: Clinical Guidelines Based on a Systematic Review and Analysis of Evidence

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