Effect of Vitamin D and Inhaled Corticosteroid Treatment on Lung Function in Children

Wu, Ann Chen; Tantisira, Kelan G.; Fuhlbrigge, Anne L.; Weiss, Scott T.; Litonjua, Augusto A.

doi:10.1164/rccm.201202-0351oc

Cited by 120 publications

(92 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies have pointed out striking links in populations between vitamin D deficiency and asthma severity or requirements for anti-inflammatory medication (27)(28)(29)(30). In previous studies investigating the immunological basis of this relationship, we have shown that 1 α,25-dihydroxyvitamin D3…”

Section: Introductionmentioning

confidence: 73%

“…This arises in part from studies demonstrating that patients with poorly controlled asthma and/or poor responsiveness to corticosteroid have significantly reduced vitamin D, at least as assessed by the circulating precursor 25-hydroxyvitamin D3 (27)(28)(29)(30)47). We and others have previously demonstrated an association with 25(OH)2D3 status and airways smooth muscle mass (27,28,48). Bronchial smooth muscle hypertrophy and hyperplasia are prominent features of airway remodelling as is subepithelial fibrosis, and IL-17A is a key mediator implicated in lung structural changes with pro-fibrotic activity within the bronchial epithelium (45).…”

Section: Nanzer Et Al 15mentioning

confidence: 99%

See 1 more Smart Citation

Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion

Nanzer

Chambers

Ryanna

et al. 2013

Journal of Allergy and Clinical Immunology

167

144

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 73%

Section: Nanzer Et Al 15mentioning

confidence: 99%

Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion

Nanzer

Chambers

Ryanna

et al. 2013

Journal of Allergy and Clinical Immunology

167

144

View full text Add to dashboard Cite

show abstract

“…Vitamin D deficiency during pregnancy is associated with low birth weight and reduced fetal bone mineral content (3), with an increased risk of preterm labor, preterm birth, and infections (2). Prenatal vitamin D deficiency is also associated with increased wheezing during the first years of life (4), increased risk of lower respiratory tract infections (5), asthma severity (6), reduced lung function, and chronic use of inhaled steroids (7). A recent prospective study of patients with asthma found that increased vitamin D concentrations were associated with better forced expiratory volume in 1 second and forced vital capacity measures (8,9).…”

Section: Clinical Relevancementioning

confidence: 99%

Effect of Prenatal versus Postnatal Vitamin D Deficiency on Pulmonary Structure and Function in Mice

Saadoon¹,

Ambalavanan²,

Zinn

et al. 2017

Am J Respir Cell Mol Biol

View full text Add to dashboard Cite

Epidemiologic studies have linked gestational vitamin D deficiency to respiratory diseases, although mechanisms have not been defined. We hypothesized that antenatal vitamin D deficiency would impair airway development and alveolarization in a mouse model. We studied the effect of antenatal vitamin D deficiency by inducing it in pregnant mice and then compared lung development and function in their offspring to littermate controls. Postnatal vitamin D deficiency and sufficiency models from each group were also studied. We developed a novel tracheal ultrasound imaging technique to measure tracheal diameter in vivo. Histological analysis estimated tracheal cartilage total area and thickness. We found that vitamin D-deficient pups had reduced tracheal diameter with decreased tracheal cartilage minimal width. Vitamin D deficiency increased airway resistance and reduced lung compliance, and led to alveolar simplification. Postnatal vitamin D supplementation improved lung function and radial alveolar count, a parameter of alveolar development, but did not correct tracheal narrowing. We conclude that antenatal vitamin D deficiency impairs airway and alveolar development and limits lung function. Reduced tracheal diameter, cartilage irregularity, and alveolar simplification in vitamin D-deficient mice may contribute to increased airways resistance and diminished lung compliance. Vitamin D supplementation after birth improved lung function and, potentially, alveolar simplification, but did not improve defective tracheal structure. This mouse model offers insight into the mechanisms of vitamin D deficiency-associated lung disease and provides an in vivo model for investigating preclinical preventive and therapeutic strategies. Clinical RelevanceThis murine investigation details structural and physiologic aberrances resulting from prenatal and postnatal vitamin D deficiency. In addition to modeling consequences on lung development, our findings emphasize differential benefit of prenatal versus postnatal vitamin D supplementation. These data provide mechanistic insight into clinical consequences of vitamin D deficiency-induced lung disease and the utility of a mouse model to test preventive and therapeutic interventions.

show abstract

“…Although our study did not have strong enough power to confirm or exclude a definite decrease in lung function, lung function was consistently decreased in the study group. According to Wu et al (2012), vitamin D deficiency is associated with poorer lung function in children with vitamin D insufficiency or sufficiency. They corroborated the suggestion that vitamin D deficiency is a potential risk in some patients.…”

Section: Lung Functionmentioning

confidence: 99%

Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis

Zhang¹,

Gong²,

Liu³

2014

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Vitamin D deficiency and insufficiency are increasingly being recognized in the general population over the last few decades. However, a number of other disorders have now been linked to vitamin D deficiency and insufficiency, including asthma and COPD. The aim of this study was to evaluate the evidence on the effect of vitamin D on asthma and COPD. We searched electronic databases including SCI, EMBASE, Ovid, and PubMed. Reviewers working independently and in duplicate extracted study characteristics, quality, and the outcomes. The weighted mean differences across trials and random-effect meta-analysis were used to pool the relative risks (RR). This is the first meta-analysis about the risk of vitamin D deficiency for asthma and COPD. Ten studies were available for this meta-analysis and systematic review. The prevalence of vitamin D deficiency was significantly greater among cases than control subjects (65%)]. Moreover, studies failed to demonstrate that COPD patients had an increased risk for vitamin D deficiency or insufficiency compared to controls (RR = 0.89, 95%CI = 0.63-1.25). Vitamin D deficiency was associated with a significant decrease in lung function in asthmatic children. Vitamin D deficiency was highly prevalent in asthma patients, and vitamin D status was associated with lung function. COPD cannot be considered as completely free of vitamin D deficiency.

show abstract

Effect of Vitamin D and Inhaled Corticosteroid Treatment on Lung Function in Children

Cited by 120 publications

References 19 publications

Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion

Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion

Effect of Prenatal versus Postnatal Vitamin D Deficiency on Pulmonary Structure and Function in Mice

Vitamin D with asthma and COPD: not a false hope? A systematic review and meta-analysis

Contact Info

Product

Resources

About