Effect of vitamin D-containing plant extracts on osteoporotic bone

Rosenberg, S. von; Wehr, U.; Bachmann, H.

doi:10.1016/j.jsbmb.2006.12.085

Cited by 8 publications

(4 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In previous studies, D. rhizoma had stimulative effects on the proliferation and differentiation of various osteoblastic cells [11,12,20,21]. The inhibitory effects of genistein, a soybean isoflavone and vitamin d -containing plant extract on bone resorption are mediated through an estrogen-like action [44,45,46]. From quantitative and morphological observations on mouse osteoblastic cells, this study suggests that the ethanol extract from D. rhizoma may have a greater effect on the proliferation and differentiation of osteoblastic cells and activity of ALP compared with the water extract, suggesting that the ethanol extract from D. rhizoma might be more effective against disease processes in bone.…”

Section: Resultsmentioning

confidence: 99%

In Vitro Anti-Osteoporosis Properties of Diverse Korean Drynariae rhizoma Phenolic Extracts

et al. 2014

View full text Add to dashboard Cite

Drynariae rhizoma has been used to prevent bone loss that occurs with increasing age. However, the chemical compounds in extracts that act on bone metabolism in herbal medicine are poorly understood. This study aimed to investigate and compare the extraction efficacy of polyphenolic compounds, antioxidant activity, and in vitro anti-osteoporosis properties of water extract (DR-DW) and ethanol extract (DR-EtOH) from D. rhizoma. Total phenolics and flavonoids were better extracted with 70% EtOH, and this extraction method also resulted in higher antioxidant activity and in vitro anti-osteoporosis properties in these extracts. In particular, the contents of phloroglucinol, protocatechuic acid ethyl ester, 2-amino-3,4-dimethyl-benzoic acid, 3-(3,5-dimethyl-pyrazol-1-yl)-benzoic acid, chlorogenic acid, syringic acid, trans-ferulic acid, (−)-epigallocatechin, epigallocatechin gallate, quercetin dehydrate, luteolin and emodin in DR-EtOH were higher than those in DR-DW. These results indicated that DR-EtOH could be a good source of natural herbs with anti-osteoporosis properties.

show abstract

Section: Resultsmentioning

confidence: 99%

In Vitro Anti-Osteoporosis Properties of Diverse Korean Drynariae rhizoma Phenolic Extracts

et al. 2014

View full text Add to dashboard Cite

show abstract

“…The studies have found that many medicinal plants have the potential to prevent and treat osteoporosis. These plants could be divided into two categories: one is vitamin D-containing plants [ 35 , 36 , 37 ], and the other is phytoestrogen-containing plants [ 38 , 39 ]. Vitamin D 3 has to be metabolized as a first step to 25(OH)D 3 in the liver, which is further hydroxylated in the 1 position to form 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].…”

Section: Discussionmentioning

confidence: 99%

Inhibitory Effects of Morinda officinalis Extract on Bone Loss in Ovariectomized Rats

Qin

Han

et al. 2009

Molecules

View full text Add to dashboard Cite

The present study was undertaken to investigate the protective effects of ethanol extract from the root of Morinda Officinalis (RMO) on ovariectomy-induced bone loss. Administration of RMO extract increased trabecular bone mineral content and bone mineral density of tibia, improved the levels of phosphorus (P), calcium (Ca) and OPG, decreased the levels of DPD/Cr, TRAP, ACTH and corticosterone, but did not reverse the levels of ALP, TNF-α and IL-6 in serum of ovariectomized rats. These findings demonstrated that RMO extract reduced bone loss in ovariectomized rats, probably via the inhibition of bone resorption, but was not involved with bone formation. Anthraquinones and polysaccharides from Morinda officinals could be responsible for their antiosteoporotic activity, and the action mechanism of these constituents needs to be further studied. Therefore, RMO has the potential to develop a clinically useful antiosteoporotic agent.

show abstract

“…daily for 10 weeks as suspension). Subgroup 3 treated weekly with alendronate, via gavage, as a positive control with a dose of 6.5 mg/kg BW/week (Rosenberg et al, 2007). At the end of experiment, one half of the animals (n = 7) were sacrificed and blood samples were collected in centrifuge tubes without anti-coagulant, then centrifuged at 3000 rpm for 20 min and the collected sera were stored until use.…”

Section: Experimental Designmentioning

confidence: 99%

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Sayed¹,

Soliman²,

Fahmy³

et al. 2013

Afr. J. Pharm. Pharmacol.

View full text Add to dashboard Cite

The efficacy of Coelatura aegyptiaca shell powder (CES, 500 mg/kg BW) was evaluated as a calcium supplement in ovariectomized (OVX) rats for ten weeks of treatment. The biochemical components and the antioxidant properties of the shell powder were determined. The bone mineral density (BMD), bone mineral content (BMC), calcium (Ca) and phosphorus (P) contents in serum and bone, serum total alkaline phosphatase (TALP) and bone alkaline phosphatase (BALP), serum calcitonin and parathyroid (PTH) hormones were determined. Furthermore, some of the oxidative stress markers [malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant capacity (TAC)] were estimated in bone. The current study revealed that CES contained 19.38% Ca, 0.315% P as well as some of antioxidant amino acids which have a potent antioxidant activity against 1,1-diphenylpicrylhydrazyl (DPPH) free radical. Administration of CES to OVX rats increased BMD, BMC, tibial Ca and P contents and BALP activity, as compared to OVX rats. An ameliorative effect was recorded in the levels of calcitonin, PTH, MDA, SOD, GPx and TAC subsequent to CES administration to OVX rats.This ameliorative effect of CES powder against osteoporosis may be attributed to its antioxidant efficacy and/or to its Ca content. In conclusion, CES may have the potential to develop a clinically useful anti-osteoporotic agent, since its effect was comparable with alendronate (6.5 mg/kg BW/week).

show abstract

Effect of vitamin D-containing plant extracts on osteoporotic bone

Cited by 8 publications

References 14 publications

In Vitro Anti-Osteoporosis Properties of Diverse Korean Drynariae rhizoma Phenolic Extracts

In Vitro Anti-Osteoporosis Properties of Diverse Korean Drynariae rhizoma Phenolic Extracts

Inhibitory Effects of Morinda officinalis Extract on Bone Loss in Ovariectomized Rats

Antiosteoporotic effect of Coelatura aegyptiaca shell powder on ovariectomized rats

Contact Info

Product

Resources

About