Effect of Vitamin D Deficiency on Hypocalcaemia After Total Thyroidectomy due to Benign Goiter

Díez, Mercedes Díaz de Cerio; Vera, Cristina; Ratia, T; Diego, Lucía; Mendoza, Fernando; Guillamot, Paloma; Román, Rosario San; Mugüerza, José M.; Rodríguez, Á. Jiménez; Medina, Carlos; Gómez, Beatriz; Granell, Javier

doi:10.1016/j.cireng.2013.09.013

Cited by 7 publications

(9 citation statements)

References 26 publications

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“…On the other hand, our results clearly showed that there is a significant association between vit D status and hypocalcemia after total thyroidectomy. Different cut-off values of vit D have reported in the studies investigated the relationship of vit D status and the incidence of hypocalcemia following thyroid surgery (6,24,25). In our work, we found that serum vit D level less than 20ng/mL was only associated with biochemical hypocalcemia, but vit D level less than 10ng/mL was an independent risk factor for the development of postoperative hypocalcemia, consistent with the study by Kirkby (6).…”

Section: Discussionsupporting

confidence: 91%

“…Similarly, Erbil et al showed that a preoperative serum vit D level less than 15 ng/mL, a postoperative serum PTH level less than 10 pg/mL, and age above 50 were the predictive factors of postoperative hypocalcemia after total thyroidectomy for nontoxic multinodular goiter (24). In another study by Díez et al, vit D<30 ng/mL and PTH<13 pg/mL were found to have independent prognostic values on the risk of hypocalcemia after total thyroidectomy for benign goiter (25). It should be stated here that the present study was only designed on the association between preoperative vit D status and the incidence of postoperative hypocalcemia.…”

Section: Discussionmentioning

confidence: 94%

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Is there a Relationship between Vitamin D Status and Hypocalcemia after Total Thyroidectomy?

et al. 2016

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context. Vitamin D plays a crucial role in calcium metabolism through parathormone-dependent process. Deficiency of this important nutrient may be associated with hypocalcemia after thyroidectomy.objective. To evaluate the role of vitamin D in predicting hypocalcemia following total thyroidectomy. subjects and methods. One hundred and fifty patients who underwent total thyroidectomy for benign or malignant thyroid disease were included in this prospective study. The association between preoperative vitamin D status and the development of hypocalcemia were investigated.results. Biochemical and symptomatic hypocalcemia were found in 28 (18.7%) and 22 (14.7%) patients, respectively. Preoperative vit D level was found significantly lower in patients with biochemical (p = 0.006) and clinical (p < 0.001) hypocalcemia in comparison to normocalcemic patients. The patients who had <10 ng/mL vit D level (severe deficiency) developed significantly more biochemical and clinical hypocalcemia than the patients with serum vit D level higher than 10 ng/mL (p = 0.030 and p < 0.001, respectively). conclusions.Although postthyroidectomy hypocalcemia is multifactorial, vit D deficiency, particularly severe form, is significantly associated with the development of biochemical and clinical hypocalcemia. Vit D supplementation can prevent this unwanted complication in such patients.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 94%

Is there a Relationship between Vitamin D Status and Hypocalcemia after Total Thyroidectomy?

et al. 2016

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“…A total of 23 studies that enrolled 877 356 participants were included for study quality assessment. 3,9,10,15–34 The study selection procedure is presented in the flow chart (Figure 1). Of the included studies, three were prospective cohort studies, nine were retrospective cohort studies, 10 were retrospective case studies and one study was a retrospective cross-sectional analysis.…”

Section: Resultsmentioning

confidence: 99%

“…Of the included studies, three were prospective cohort studies, nine were retrospective cohort studies, 10 were retrospective case studies and one study was a retrospective cross-sectional analysis. 3,9,10,15–34 Eight studies were conducted in European countries, 12 in Asian countries and three in the USA. The characteristics of the included studies are presented in Table 1.…”

Section: Resultsmentioning

confidence: 99%

Risk factors for postoperative hypocalcaemia after thyroidectomy: A systematic review and meta-analysis

Chen

Zhao

et al. 2021

J Int Med Res

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Objective A meta-analysis to investigate the risk factors for postoperative hypocalcaemia after thyroidectomy in adult patients. Methods A systematic search of publications in the electronic databases (PubMed®, The Cochrane Library, Web of Science, OVID and Embase®) from inception to June 2020 was conducted. Screening of titles, abstracts and full texts and data extraction were independently performed by two authors. The OR was selected as the pooled estimate. Results The analysis included 23 studies. Twelve significant risk factors for postoperative hypocalcaemia were identified: hypoparathyroidism, OR 5.58; total thyroidectomy, OR 3.59; hypomagnesaemia, OR 2.85; preoperative vitamin D deficiency, OR 2.32; female sex, OR 1.49; thyroid malignancy, OR 1.85; thyroiditis, OR 1.48; substernal multinodular goitres, OR 1.70; parathyroidectomy, OR 1.58; central compartment neck dissection, OR 1.17; modified radical neck dissection, OR 1.57; and central neck dissection, OR 1.54. Conclusions This meta-analysis provides moderate-to-high quality evidence that the 12 risk factors were predictive of postoperative hypocalcaemia, which should be monitored closely before thyroidectomy.

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“…The advantage of using vitamin D as a predictor for postoperative hypocalcaemia is (i) easy to estimate (ii) any deficiency can be easily corrected. 1,4,5 However, the association between low vitamin D and post-operative hypocalcaemia has not been demonstrated regularly.6-8 …”

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confidence: 99%

Role of vitamin D as a risk factor in post-thyroidectomy transient hypocalcemia: a prospective study

2016

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INTRODUCTIONTotal thyroidectomy is one the most common surgeries performed worldwide. Surgeons prefer a total thyroidectomy to subtotal or Dunhill thyroidectomy. With increase in the number of thyroidectomies, the incidence of post-operative hypocalcaemia has seen a rise as well.1 Risk factors for post-operative hypocalcaemia are older age group, female sex, Grave's disease and inadvertent excision of parathyroid glands. Hormonal risk factors include pre-operative low levels of serum calcium, paratharmone and vitamin D levels. 2,3Deficiency of vitamin D has long been debated as a risk factor for post thyroidectomy hypocalcemia. The advantage of using vitamin D as a predictor for postoperative hypocalcaemia is (i) easy to estimate (ii) any deficiency can be easily corrected. 1,4,5 However, the association between low vitamin D and post-operative hypocalcaemia has not been demonstrated regularly.6-8 METHODSA prospective study which includes patients treated with total thyroidectomy with or without neck dissections. All the patients underwent estimation of serum calcium, serum albumin and vitamin D levels preoperatively. Serum calcium was repeated at the occurrence of symptoms of hypocalcaemia, at post-operative day 3 and at three months. Patients who had persistent hypocalcaemia at the end of three months were excluded from the study. Other exclusion criteria were abnormal serum albumin, patients taking calcium supplements preoperatively and patients with renal diseases. ABSTRACT Background:With increase in the number of thyroidectomies, the incidence of post-operative hypocalcaemia has seen a rise as well. Deficiency of vitamin D has long been debated as a risk factor for post thyroidectomy hypocalcaemia. The advantage of using vitamin D as a predictor for post-operative hypocalcaemia is (i) easy to estimate (ii) any deficiency can be easily corrected. Methods: A prospective study with total of sixty one patients who underwent total thyroidectomy irrespective of the pathology. Serum calcium and vitamin D were investigated preoperatively. Serum calcium was repeated in postoperative period. The association between vitamin D and hypocalcaemia was evaluated using Fischer's exact test. Results: Hypocalcaemia was seen in 14.28% of patients with lower vitamin D levels. When Fischer's exact test was applied, two tailed 'p' value is 0.5195, which is not statistically significant. Conclusions:Though vitamin D estimation can be an easy method in predicting post thyroidectomy hypocalcaemia, our study does not indicate the same.

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Effect of Vitamin D Deficiency on Hypocalcaemia After Total Thyroidectomy due to Benign Goiter

Cited by 7 publications

References 26 publications

Is there a Relationship between Vitamin D Status and Hypocalcemia after Total Thyroidectomy?

Is there a Relationship between Vitamin D Status and Hypocalcemia after Total Thyroidectomy?

Risk factors for postoperative hypocalcaemia after thyroidectomy: A systematic review and meta-analysis

Role of vitamin D as a risk factor in post-thyroidectomy transient hypocalcemia: a prospective study

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