Effect of vitamin D fortified foods on bone markers and muscle strength in women of Pakistani and Danish origin living in Denmark: a randomised controlled trial

Grønborg, Ida Marie; Tetens, Inge; Andersen, Elisabeth Wreford; Kristensen, Michael; Larsen, Rikke Ellekilde Kofoed; Tran, Thanh L. L.; Andersen, Rikke

doi:10.1186/s12937-019-0504-9

Cited by 24 publications

(25 citation statements)

References 39 publications

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“…( 28‐34 ) In studies including two vitamin D groups (Pakistani versus Danish women ( 35 ) and depressive versus non‐depressive individuals ( 11 ) ) and similar two consecutive placebo groups, the two groups are registered as two separate studies, although published in one article. ( 11,35 )…”

Section: Methodsmentioning

confidence: 99%

“…If a study included two vitamin D groups (different doses) but only one placebo group, we a priori included the placebo group and the group treated with the lowest dose of vitamin D. Sensitivity analyses were used to determine whether inclusion of the highest-dose group changed the pooled estimate. (28)(29)(30)(31)(32)(33)(34) In studies including two vitamin D groups (Pakistani versus Danish women (35) and depressive versus non-depressive individuals (11) ) and similar two consecutive placebo groups, the two groups are registered as two separate studies, although published in one article. (11,35) In factorial designs, including, for example, a group treated with exercise (AE vitamin D), (13) we included the two groups treated with vitamin D versus placebo.…”

Section: Inclusion Criteriamentioning

confidence: 99%

“…(28)(29)(30)(31)(32)(33)(34) In studies including two vitamin D groups (Pakistani versus Danish women (35) and depressive versus non-depressive individuals (11) ) and similar two consecutive placebo groups, the two groups are registered as two separate studies, although published in one article. (11,35) In factorial designs, including, for example, a group treated with exercise (AE vitamin D), (13) we included the two groups treated with vitamin D versus placebo. Studies examining athletes were excluded, as those studies in general are more methodologically heterogenic and because training may exert an independent effect on muscle health, (36,37) complicating a direct comparison.…”

Section: Inclusion Criteriamentioning

confidence: 99%

“…S2 and S3). (9,(11)(12)(13)(14)(15)(16)(28)(29)(30)(31)(32)(33)(34)(35)(39)(40)(41)(42)45,(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(60)(61)(62)(63)(64)(65)(67)(68)(69)(70)(71)(72)(73)(83)(84)(85)(86)(87)(88)(89)(90)(91) 54 8747 Effect parameter…”

Section: Physical Performancementioning

confidence: 99%

“…Handgrip (9,11,13,15,16,(28)(29)(30)(31)33,35,39,40,42,48,49,51,53,55,57,65,(68)(69)(70)72,(83)(84)(85)(86)(87)(88)90,91) 35 5946 Elbow extension (15,16,39,53) 4 235 Elbow flexion (15,16,39,53,86) 5 636 Knee extension (13,15,16,(33)(34)(35)39,42,(52)(53)(54)…”

Section: Physical Performancementioning

confidence: 99%

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Vitamin D and Muscle Health: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials

Bislev

Grove‐Laugesen

Rejnmark

2020

Journal of Bone and Mineral Research

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The objective of this study was to investigate the effects of vitamin D supplementation versus placebo on muscle health. For this systematic review and trial-level meta-analysis of placebo-controlled trials, a systematic search of randomized controlled trials published until October 2020 was performed in Medline, Embase, and Google Scholar. We included studies in humans (except athletes) on supplementation with vitamin D2 or D3 versus placebo, regardless of administration form (daily, bolus, and duration) with or without calcium co-supplementation. The predefined endpoints were physical performance reported as timed up and go test (TUG; seconds), chair rising test (seconds), 6-minute walking distance (m), and Short Physical Performance Battery (SPPB; points). Furthermore, endpoints were maximum muscle strength (Newton) measured at handgrip, elbow flexion, elbow extension, knee flexion, and knee extension, as well as muscle (lean tissue) mass (kg). Falls were not included in the analysis. Cochrane Review Manager (version 5.4.1.) calculating mean difference (MD) using a random effect model was used. In total, 54 randomized controlled trials involving 8747 individuals were included. Vitamin D versus placebo was associated with a significantly longer time spent performing the TUG (MD 0.15 [95% confidence interval (CI) 0.03 to 0.26] seconds, N = 19 studies, I 2 = 0%, n = 5223 participants) and a significant lower maximum knee flexion strength (MD -3.3 [À6.63 to À0.03] Newton, N = 12 studies, I 2 = 0%, n = 765 participants). Total score in the SPPB showed a tendency toward worsening in response to vitamin D compared with placebo (MD À0.18 [À0.37 to 0.01] points, N = 8 studies, I 2 = 0%, n = 856 participants). Other measures of muscle health did not show between-group differences. In subgroup analyses, including studies with low vitamin D levels, effects of vitamin D supplementation did not differ from placebo. Available evidence does not support a beneficial effect of vitamin D supplementation on muscle health. Vitamin D may have adverse effects on muscle health, which needs to be considered when recommending vitamin D supplementation.

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Section: Methodsmentioning

confidence: 99%

Section: Inclusion Criteriamentioning

confidence: 99%

Section: Inclusion Criteriamentioning

confidence: 99%

Section: Physical Performancementioning

confidence: 99%

Section: Physical Performancementioning

confidence: 99%

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Vitamin D and Muscle Health: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials

Bislev

Grove‐Laugesen

Rejnmark

2020

Journal of Bone and Mineral Research

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Vitamin D/Vitamin D Receptor Signaling Attenuates Skeletal Muscle Atrophy by Suppressing Renin-Angiotensin System

Qin

Poon

et al. 2020

Journal of Bone and Mineral Research

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The nutritional level of vitamin D may affect musculoskeletal health. We have reported that vitamin D is a pivotal protector against tissue injuries by suppressing local renin-angiotensin system (RAS). This study aimed to explore the role of the vitamin D receptor (VDR) in the protection against muscle atrophy and the underlying mechanism. A cross-sectional study on participants (n = 1034) in Shanghai (China) was performed to analyze the association between vitamin D level and the risk of low muscle strength as well as to detect the circulating level of angiotensin II (Ang II). In animal studies, dexamethasone (Dex) was applied to induce muscle atrophy in wild-type (WT) and VDR-null mice, and the mice with the induction of muscle atrophy were treated with calcitriol for 10 days. The skeletal muscle cell line C2C12 and the muscle satellite cells were applied in in vitro studies. The increased risk of low muscle strength was correlated to a lower level of vitamin D (adjusted odds ratio [OR] 0.58) accompanied by an elevation in serum Ang II level. Ang II impaired the myogenic differentiation of C2C12 myoblasts as illustrated by the decrease in the area of myotubes and the downregulation of myogenic factors (myosin heavy chain [MHC] and myogenic differentiation factor D [MyoD]). The phenotype of muscle atrophy induced by Dex and Ang II was aggravated by VDR ablation in mice and in muscle satellite cells, respectively, and mediated by RAS and its downstream phosphatidylinositol 3-kinase/protein kinase B/forkhead box O1 (PI3K/Akt/FOXO1) signaling. Calcitriol treatment exhibited beneficial effects on muscle function as demonstrated by the increased weight-loaded swimming time, grip strength, and fiber area, and improved fiber type composition via regulating ubiquitin ligases and their substrates MHC and MyoD through suppressing renin/Ang II axis. Taken together, VDR protects against skeletal muscle atrophy by suppressing RAS. Vitamin D could be a potential agent for the prevention and treatment of skeletal muscle atrophy.

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Individual participant data (IPD)-level meta-analysis of randomised controlled trials to estimate the vitamin D dietary requirements in dark-skinned individuals resident at high latitude

et al. 2021

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Context and purposeThere is an urgent need to develop vitamin D dietary recommendations for dark-skinned populations resident at high latitude. Using data from randomised controlled trials (RCTs) with vitamin D 3 -supplements/fortified foods, we undertook an individual participant data-level meta-regression (IPD) analysis of the response of wintertime serum 25-hydroxyvitamin (25(OH)D) to total vitamin D intake among dark-skinned children and adults residing at ≥ 40° N and derived dietary requirement values for vitamin D. Methods IPD analysis using data from 677 dark-skinned participants (of Black or South Asian descent; ages 5-86 years) in 10 RCTs with vitamin D supplements/fortified foods identified via a systematic review and predefined eligibility criteria. Outcome measures were vitamin D intake estimates across a range of 25(OH)D thresholds. Results To maintain serum 25(OH)D concentrations ≥ 25 and 30 nmol/L in 97.5% of individuals, 23.9 and 27.3 µg/day of vitamin D, respectively, were required among South Asian and 24.1 and 33.2 µg/day, respectively, among Black participants. Overall, our age-stratified intake estimates did not exceed age-specific Tolerable Upper Intake Levels for vitamin D. The vitamin D intake required by dark-skinned individuals to maintain 97.5% of winter 25(OH)D concentrations ≥ 50 nmol/L was 66.8 µg/day. This intake predicted that the upper 2.5% of individuals could potentially achieve serum 25(OH)D concentrations ≥ 158 nmol/L, which has been linked to potential adverse effects in older adults in supplementation studies. Conclusions Our IPD-derived vitamin D intakes required to maintain 97.5% of winter 25(OH)D concentrations ≥ 25, 30 and 50 nmol/L are substantially higher than the equivalent estimates for White individuals. These requirement estimates are also higher than those currently recommended internationally by several agencies, which are based predominantly on data from Whites and derived from standard meta-regression based on aggregate data. Much more work is needed in dark-skinned populations both in the dose-response relationship and risk characterisation for health outcomes. Trail registration PROSPERO International Prospective Register of SystematicReviews (Registration Number: CRD42018097260)

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Effect of vitamin D fortified foods on bone markers and muscle strength in women of Pakistani and Danish origin living in Denmark: a randomised controlled trial

Cited by 24 publications

References 39 publications

Vitamin D and Muscle Health: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials

Vitamin D and Muscle Health: A Systematic Review and Meta-analysis of Randomized Placebo-Controlled Trials

Vitamin D/Vitamin D Receptor Signaling Attenuates Skeletal Muscle Atrophy by Suppressing Renin-Angiotensin System

Individual participant data (IPD)-level meta-analysis of randomised controlled trials to estimate the vitamin D dietary requirements in dark-skinned individuals resident at high latitude

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