Effect of vitamin D on hepatic cellular growth in the rat

Lal, Harbans; Marya, R.K.; Saini, A. S.

doi:10.1016/s0271-5317(86)80163-4

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…It has been shown that vitamin D supplementation in albino rats results in not only a gain in body weight but also in increased liver weight, hyperplasia of the liver cells and decreased liver cell size (22). Further, the pups of pregnant female rats on vitamin D supplementation weighed more at birth, the effect however, was more conspicuous from day 10 onwards.…”

Section: Growthmentioning

confidence: 99%

Vitamin D: Actions for the new millennium

Lai

Pandey

Aggarwal

2000

Indian J Clin Biochem

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The past two decades have witnessed new facets in vitamin D metabolism. Free vitamin D3 till now considered to be limited to animal sources, has been shown to occur in plants. Further, the extrarenal synthesis of active vitamin D3 or calcitriol has been documented in physiological as well as in certain pathological conditions. At the cellular level, calcitriol acts through a dual mechanism.The genomic pathway involves the vitamin D receptor (VDR) which is of ubiquitous distribution and linked with various diseases. Besides, a nongenomic VDR -independent pathway also exists. The biological effects of calcitriol can no longer be dismissed by merely referring to calcium/bone homeostasis. It enhances the perinatal growth and suppresses the abnormal growth, as well. The effects on the endocrine, immune, cardiovascular, reproductive and nervous systems have also been characterized. It is compelling to believe that calcitriol and/or its analogues will find extensive applications at least in the treatment of osteoporosis, perinatal growth retardation, neoplasia, psoriasis, insulin resistance and transplantation.

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Section: Growthmentioning

confidence: 99%