Effect of vitamin D on transepithelial phosphate transport in chick intestine.

Peterlik, Meinrad; Wasserman, R H

doi:10.1152/ajpendo.1978.234.4.e379

Cited by 26 publications

(24 citation statements)

References 14 publications

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“…Polyphagia results in increased dietary phosphate intake, but the effect of hyperthyroidism on phosphate absorption is unknown. The active transport of phosphate across the gut mucosa is increased by 1,25 (OH),D, (Peterlik and Wasserman 1978), and is also potentiated by thyroid hormones acting independently and possibly synergistically with 1,25 (OH),D, (Cross and others 1990). Further sources of elevated plasma phosphate in hyperthyroidism are those mobilised as a result of increased bone resorption and soft tissue catabolism.…”

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confidence: 99%

Study of calcium homeostasis in feline hyperthyroidism

Barber

Elliott

1996

J of Small Animal Practice

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Thirty cats with untreated hyperthyroidism were blood sampled and their calcium homeostatic mechanisms and renal function assessed. The results were compared with those obtained from 38 age-matched control cats. The hyperthyroid group of cats were found to have significantly lower blood ionised calcium and plasma creatinine concentrations and significantly higher plasma phosphate and parathyroid hormone concentrations. Hyperparathyroidism occurred in 77 per cent of hyperthyroid cats, with parathyroid hormone concentrations reaching up to 19 times the upper limit of the normal range. The aetiology, significance and reversibility of hyperparathyroidism in feline hyperthyroidism remains to be established but could have important implications for both bone strength and renal function.

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confidence: 99%

Study of calcium homeostasis in feline hyperthyroidism

Barber

Elliott

1996

J of Small Animal Practice

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“…The active form of the vitamin, 1,25-dihydroxycholecalciferol [1, 2D3], has been shown to enhance the intestinal absorption of phosphate (2)(3)(4). The effect of 1,25-(OH)2D3 on the reabsorption of phosphate in the kidney is in dispute.…”

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confidence: 99%

In vitro stimulation of phosphate uptake in isolated chick renal cells by 1,25-dihydroxycholecalciferol.

Liang¹,

Barnes²,

Balakir³

et al. 1982

Proc. Natl. Acad. Sci. U.S.A.

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Renal cells isolated from vitamin D-deficient chicks had an increased Na+-dependent phosphate uptake when preincubated with 1,25-dihydroxycholecalciferol [1,25-(OH)2D3]. Phosphate uptake in the absence of Na+ and methyl a-glucoside uptake dependent on Na+ were not affected. Phosphate uptake was stimulated 15% by 0.010 pM 1,25-(OH)2D3. Maximal enhancement of 30% was obtained with 100 pM. The uptake when fully stimulated by preincubation in vitro approximated the uptake of cells isolated from chicks that were previously repleted with 1,25-(OH)2D3 in vivo. Cells from repleted chicks were not stimulated additionally when preincubated with 1,25-(OH)2D3 in vitro. The increase in phosphate uptake could be measured after a 1-hr preincubation period; full response required at least 2 hr. Phosphate uptake induced by 1,25-(OH)2D3 was blocked by cycloheximide and actinomycin D. Enhancement of phosphate uptake was relatively specific for the 1,25-(OH)2D3 analog of vitamin D3. * To whom reprint requests should be addressed. 3532The publication costs ofthis article were defrayed in part by page charge payment. This article must therefore be hereby marked "advertisement" in accordance with 18 U. S. C. §1734 solely to indicate this fact.

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“…Otherwise, total digestibility of phosphorus was significantly higher in PL‐pigs than in controls. The main place for phosphorus absorption is the upper small intestine, whereas the absorption from large intestine can be neglected (Cramer, 1972; Juan et al., 1976; Walling, 1977; Peterlik and Wasserman, 1978; Schröder et al., 1996). However, the present study suggests, that phosphorus absorption takes place partly in the large intestine.…”

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confidence: 99%

Digestibility rates of major and trace elements in pancreatic duct‐ligated pigs

Kammlott

Karthoff

Stemme

et al. 2005

Animal Physiology Nutrition

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Ligation of pancreatic duct in pigs leads to a severe maldigestion of calcium and magnesium. Substitution of missing enzymes results in a 'normalization' of the digestibility rates of these elements. In comparison to controls the pre-caecal phosphorus digestibility decreased, but the total digestibility rates increased, after ligation of the pancreatic duct. Furthermore, the total amount of absorbed phosphorus was significantly higher in pancreatic duct ligated pigs. Further studies have to be carried out to investigate, whether phosphorus in exocrine pancreatic insufficiency is excreted with urine, as in this study the observed Ca:P-ratio in blood was in a physiological range. Without a forced renal excretion of phosphorus, consequences and risks (e.g. secondary hyperparathyroidism) of the regulation have to be considered. Regarding the elements sodium, potassium and chloride, an increased faecal excretion could be observed in pancreatic duct ligated pigs. As a substitution with enzyme products led to digestibility rates similar to those in controls, no losses of electrolytes have to be feared. Even though pancreatic juice seems to have influences on the digestibility of investigated trace elements (copper, zinc, iron and manganese), it did not lead to severe imbalances in the corresponding mineral metabolism.

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Effect of vitamin D on transepithelial phosphate transport in chick intestine.

Cited by 26 publications

References 14 publications

Study of calcium homeostasis in feline hyperthyroidism

Study of calcium homeostasis in feline hyperthyroidism

In vitro stimulation of phosphate uptake in isolated chick renal cells by 1,25-dihydroxycholecalciferol.

Digestibility rates of major and trace elements in pancreatic duct‐ligated pigs

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