Effect of vitamin D replacement on depression in multiple sclerosis patients

Kotb, Mamdouh Ali; Kamal, Ahmed; Aldossary, Nasser M.; Bedewi, Mohamed Abdelmohsen

doi:10.1016/j.msard.2019.01.029

Cited by 11 publications

(13 citation statements)

References 49 publications

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“…In our study, the more deficient 25hydroxy Vitamin D, the more severity of depression. This agree with Kotb et al [41] who demonstrated that lower vitamin D levels are associated with higher depressive scores.…”

Section: Resultssupporting

confidence: 92%

Untitled

2021

ANN

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Section: Resultssupporting

confidence: 92%

Untitled

2021

ANN

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“…Regarding the effect of vitamin D supplementation on depressive symptoms in pwMS, Taylor 2014 et al [ 47 ] and Taylor 2018 [ 49 ] found that vitamin D supplementation reduced depression risk for pwMS. These findings were confirmed by Kotb et al study [ 50 ]. The authors reported that lower vitamin D levels were associated with higher depressive scores and suggested that vitamin D replacement could have improved depressive symptoms in patients with RRMS.…”

Section: Resultssupporting

confidence: 83%

“…Of the 37 studies that were screened for eligibility, only 11 were considered eligible and included. Among them, nine were full text articles, two were abstracts, seven were cross-sectional studies [ 26 , 43 , 44 , 45 , 46 , 47 , 48 ] one was a retrospective cohort study [ 49 ] and two were prospective longitudinal studies [ 50 , 51 ]. Only one study was a RCT [ 52 ].…”

Section: Resultsmentioning

confidence: 99%

Vitamin D and Depressive Symptoms in Adults with Multiple Sclerosis: A Scoping Review

Concerto

Rodolico

Ciancio

et al. 2021

IJERPH

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Background. Vitamin D deficiency has been correlated with Multiple Sclerosis (MS) risk and disease activity. There is some controversy as to whether vitamin D could have an impact on depressive symptoms in people with MS (pwMS). The aim of this scoping review was to evaluate the association between vitamin D status and depressive symptoms in pwMS. Methods. We searched databases to include studies published up to March 2021 to provide an overview of the available evidence on the correlation between vitamin D status and depressive symptoms in pwMS. The eligibility criteria were as follows: studies evaluating the use of vitamin D measurement on depressive symptoms in patients suffering from MS, including randomized and non-randomized studies; studies written in English; and studies exploring an adult population over the age of 18. Results. Eleven studies met our inclusion criteria: two of them were abstracts only; the majority were cross-sectional studies; two were prospective longitudinal studies; one was a retrospective cohort study; and one was a randomized placebo-controlled trial (RCT). Of the eleven studies selected, seven showed a potential correlation between low vitamin D levels and depressive symptoms. Conclusion. Future RCT studies should include patients with greater severity of depressive symptoms and should consider confounding factors such as sun exposure and seasonal variation of vitamin D.

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“…In experimental studies examining the effect of vitamin D supplementation, it has been observed that low serum vitamin D levels can exacerbate MS symptoms and are associated with higher relapse rates, new lesions and greater disability [162][163][164][165]. Furthermore, daily cholecalciferol supplementation has recently been shown to improve depressive symptoms in patients with relapsing remitting MS [166].…”

Section: Multiple Sclerosismentioning

confidence: 99%

“…Lower vitamin D levels were associated with higher depressive scores and vitamin D supplementation improved these symptoms [166]. The majority of studies in the MS setting suffer from substantial heterogeneity in terms of study design, baseline serum vitamin D levels and outcome measures, making crosscomparison difficult and results inconclusive.…”

Section: Multiple Sclerosismentioning

confidence: 99%

Consensus statement from 2nd International Conference on Controversies in Vitamin D

Giustina

Adler

Binkley

et al. 2020

Rev Endocr Metab Disord

224

169

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The 2 nd International Conference on Controversies in Vitamin D was held in Monteriggioni (Siena), Italy, September 11-14, 2018. The aim of this meeting was to address ongoing controversies and timely topics in vitamin D research, to review available data related to these topics and controversies, to promote discussion to help resolve lingering issues and ultimately to suggest a research agenda to clarify areas of uncertainty. Several issues from the first conference, held in 2017, were revisited, such as assays used to determine serum 25-hydroxyvitamin D [25(OH)D] concentration, which remains a critical and controversial issue for defining vitamin D status. Definitions of vitamin D nutritional status (i.e. sufficiency, insufficiency and deficiency) were also revisited. New areas were reviewed, including vitamin D threshold values and how they should be defined in the context of specific diseases, sources of vitamin D and risk factors associated with vitamin D deficiency. Non-skeletal aspects related to vitamin D were also discussed, including the reproductive system, neurology, chronic kidney disease and falls. The therapeutic role of vitamin D and findings from recent clinical trials were also addressed. The topics were considered by 3 focus groups and divided into three main areas: 1) "Laboratory": assays and threshold values to define vitamin D status; 2) "Clinical": sources of vitamin D and risk factors and role of vitamin D in non-skeletal disease and 3) "Therapeutics": controversial issues on observational studies and recent randomized controlled trials. In this report, we present a summary of our findings.

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Effect of vitamin D replacement on depression in multiple sclerosis patients

Cited by 11 publications

References 49 publications

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Untitled

Vitamin D and Depressive Symptoms in Adults with Multiple Sclerosis: A Scoping Review

Consensus statement from 2nd International Conference on Controversies in Vitamin D

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