2014
DOI: 10.1002/cbf.3044
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Effect of vitamin D3on behavioural and biochemical parameters in diabetes type 1‐induced rats

Abstract: Diabetes is associated with long-term complications in the brain and reduced cognitive ability. Vitamin D3 (VD3 ) appears to be involved in the amelioration of hyperglycaemia in streptozotocin (STZ)-induced diabetic rats. Our aim was to analyse the potential of VD3 in avoiding brain damage through evaluation of acetylcholinesterase (AChE), Na(+) K(+) -adenosine triphosphatase (ATPase) and delta aminolevulinate dehydratase (δ-ALA-D) activities and thiobarbituric acid reactive substance (TBARS) levels from cereb… Show more

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Cited by 14 publications
(8 citation statements)
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“…One method of testing long-term hippocampus and prefrontal cortex-dependent learning that does not depend on locomotor activity for assessment is fear-conditioned learning. STZinduced diabetes has been shown to lead a reduction in longterm hippocampus-dependent fear learning assessed during contextual fear-conditioning testing (6). We similarly observed impairment in long-term hippocampus-dependent learning at 24 h, as well as impaired prefrontal cortex-dependent learning at 4 and 14 days in the diabetic WT STZ mice.…”
Section: Discussionsupporting
confidence: 66%
“…One method of testing long-term hippocampus and prefrontal cortex-dependent learning that does not depend on locomotor activity for assessment is fear-conditioned learning. STZinduced diabetes has been shown to lead a reduction in longterm hippocampus-dependent fear learning assessed during contextual fear-conditioning testing (6). We similarly observed impairment in long-term hippocampus-dependent learning at 24 h, as well as impaired prefrontal cortex-dependent learning at 4 and 14 days in the diabetic WT STZ mice.…”
Section: Discussionsupporting
confidence: 66%
“…Skeletal muscle mitochondrial function declines and oxidative stress increases with advancing age [19], and these changes have been implicated in the etiology of sarcopenia [20]. 1, 25OHD was re-ported to have a significant physiological antioxidant activity [21]. Thus 1, 25OHD passively acts by activation of the antioxidant pathway.…”
Section: Discussionmentioning
confidence: 99%
“…Over expression of reactive oxygen species (ROS) stimulated by disruption of cerebral blood flow was shown to be one of the main causes of vascular dementia-induced cognitive deficits in a rat model [20]. 1, 25OHD was reported to have significant physiological antioxidant activity [21]. These results suggest a potential role of vitamin D in treating patients with cognitive dysfunction in DM.…”
Section: Cognitive Functionmentioning
confidence: 96%