Effect of vitamin D supplementation versus placebo on recovery delay among COVID-19 Tunisian patients: a randomized-controlled clinical trial

Abroug, Héla; Maatouk, Amani; Bennasrallah, Cyrine; Dhouib, Wafa; Fredj, Manel Ben; Zemni, Imen; Kacem, Meriem; Mhalla, S.; Nouira, Sarra; Belgacem, Manel Ben; Nasri, Aymen; Klii, R.; Loussaief, C.; Alya, Nissaf Ben; Bouanène, Inès; Sriha, Asma Belguith

doi:10.1186/s13063-023-07114-5

Cited by 8 publications

(14 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In terms of the efficacy of vitamin D supplementation against COVID-19, aside from the dosage, the repetitiveness of supplementation seems to be a crucial factor in reducing COVID-19-related mortality. In a randomized clinical study carried out in Tunisia, a high, single dose of vitamin D (200,000 IU) did not alter the period of hospitalization in comparison to the placebo group who received physiological saline [44]. However, an observational study conducted in the United Kingdom showed that different regimens of vitamin D3 supplementation, administered during the period of hospitalization, were successful in decreasing mortality among study participants who at the point of hospitalization were vitamin D deficient [45].…”

Section: Discussionmentioning

confidence: 94%

Effect of Vitamin D3 Supplementation on Severe COVID-19: A Meta-Analysis of Randomized Clinical Trials

Sobczak,

Pawliczak

2024

Nutrients

View full text Add to dashboard Cite

Since the beginning of the COVID-19 pandemic, vitamin D has attracted interest due to its immunomodulatory properties. Numerous studies show a correlation between vitamin D levels and COVID-19 cases and mortality. Therefore, we conducted a meta-analysis in order to assess the relationship between vitamin D3 supplementation and COVID-19 severity. We included 13 randomized clinical trials that contained the analyzed endpoints: length of COVID-19 hospitalization, number of intensive care unit (ICU) admissions, length of stay in the ICU, number of cases requiring any supplemental oxygenation, duration of any supplemental oxygenation, number of overall mortality and number of deaths associated with COVID-19. The relative risk with 95% confidence interval (CI) and the mean difference with 95% CI were calculated to compare the effect. A random effects model was used to calculate effect sizes. Our meta-analysis showed a positive effect of vitamin D3 supplementation on ICU admission (RR = 0.73; 95% CI [0.57; 0.95], p = 0.02, I2 = 19.6%) and mortality associated with COVID-19 among patients (RR = 0.56; 95% CI [0.34; 0.91]; p = 0.02; I2 = 0%). Vitamin D3 supplementation may potentially reduce the risk of ICU admission and death associated with COVID-19.

show abstract

Section: Discussionmentioning

confidence: 94%

Effect of Vitamin D3 Supplementation on Severe COVID-19: A Meta-Analysis of Randomized Clinical Trials

Sobczak,

Pawliczak

2024

Nutrients

View full text Add to dashboard Cite

show abstract

“…In total, 17 articles referring to 15 RTCs reported data on vitamin D supplementation in COVID-19 management (Table 2). They were conducted in Tunisia (n = 1 RCT) [44], the United States (n = 2 RCTs) [45,50], Croatia (n = 1 RCT) [46], Russia (n = 2 RCTs) [47,52], Belgium (n = 1 RCT) [49], Spain (n = 1 RCT) [51], Iran (n = 1 RCT) [53], Argentina (n = 1 RCT) [54], India (n = 1 RCT) [58], Mexico (n = 2 RCTs) [59,60], Brazil (n = 1 RCT, n = 3 papers) [55][56][57], and one RCT in four countries [48] (Table 2). The population enrolled was relatively small, ranging from 40 [58] to 240 individuals [55][56][57], with a varying proportion of females, from 37% [48] to 72% [46].…”

Section: Vitamin Dmentioning

confidence: 99%

The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prevention and Management of COVID-19 and Long-COVID: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials

Sinopoli,

Sciurti,

Isonne

et al. 2024

Nutrients

View full text Add to dashboard Cite

This review aims to evaluate the efficacy of any vitamin administration(s) in preventing and managing COVID-19 and/or long-COVID. Databases were searched up to May 2023 to identify randomized clinical trials comparing data on the effects of vitamin supplementation(s) versus placebo or standard of care on the two conditions of interest. Inverse-variance random-effects meta-analyses were conducted to estimate pooled risk ratios (RRs) and 95% confidence intervals (CIs) for all-cause mortality between supplemented and non-supplemented individuals. Overall, 37 articles were included: two regarded COVID-19 and long-COVID prevention and 35 records the COVID-19 management. The effects of vitamin D in preventing COVID-19 and long-COVID were contrasting. Similarly, no conclusion could be drawn on the efficacy of multivitamins, vitamin A, and vitamin B in COVID-19 management. A few positive findings were reported in some vitamin C trials but results were inconsistent in most outcomes, excluding all-cause mortality (RR = 0.84; 95% CI: 0.72–0.97). Vitamin D results were mixed in most aspects, including mortality, in which benefits were observed in regular administrations only (RR = 0.67; 95% CI: 0.49–0.91). Despite some benefits, results were mostly contradictory. Variety in recruitment and treatment protocols might explain this heterogeneity. Better-designed studies are needed to clarify these vitamins’ potential effects against SARS-CoV-2.

show abstract

“…After full article reading, nine articles [16,28,[31][32][33][34][35][36][37] were selected for review and 14 articles were excluded. Reasons for exclusion were: high vs. low dose VDS [38][39][40], no specific numbers of patients who were admitted in ICU [14,15,30,[41][42][43][44][45], failure of randomization [29], and not a randomised trial [46,47]. Characteristics of the nine selected randomised trials are summarized in Table 1.…”

Section: Vds To Covid-19 Patients and Admission To Icumentioning

confidence: 99%

Vitamin D, acute respiratory infections, and Covid-19: the curse of small-size randomised trials. A critical review with meta-analysis of randomised trials

Autier,

Doi,

Mullie

et al. 2024

Preprint

View full text Add to dashboard Cite

Background: Randomised trials conducted before 2021 indicated that vitamin D supplementation (VDS) was able to prevent severe COVID-19 and acute respiratory infections (ARI). However, these health benefits were not confirmed by larger randomised trials published after 2021. Objective: To examine the characteristics of randomised trials on VDS to COVID-19 patients and admission to intensive care unit (ICU), and on VDS for the prevention of ARI. Method: A systematic search retrieved randomised trials on VDS to COVID-19 patients and admission to ICU. Data on VDS and ARI were extracted from the meta-analysis of Jolliffe et al., 2021. The associations between VDS vs no VDS, and admission to ICU were evaluated using random effect models. Meta-analyses were done for all trials and by groups trial size. Publication bias was assessed using the LFK index (no bias if index between -1 and +1) and the Trim and Fill method. Results: Nine trials on VDS for preventing admission to ICU were identified. The summary odds ratio (SOR) was 0.61 (95%CI: 0.39-0.95) for all trials, 0.34 (0.13-0.93) for trials including 50 to <106 patients and 0.88 (0.62-1.24) for trials including 106 to 548 patients (effect modification: p=0.04). The LFK index was -3.79, and after Trim and Fill, the SOR was 0.80 (0.40-1.61). The SOR for the 37 trials on VDS for ARI prevention was 0.92 (0.86-0.99) for all trials, 0.69 (0.57-0.83) for trials including 25 to <248 patients and 0.98 (0.94-1.03) for trials including 248 to 16,000 patients (effect modification p=0.0001). The LFK index was -3.11, and after Trim and Fill, the SOR was 0.96 (0.88-1.05). Conclusion: Strong publication bias affected randomised trials on VDS for the prevention of severe COVID-19 and of ARI. Systematic reviews should beware of small-size randomised trials that generally exaggerate health benefits.

show abstract

Effect of vitamin D supplementation versus placebo on recovery delay among COVID-19 Tunisian patients: a randomized-controlled clinical trial

Cited by 8 publications

References 32 publications

Effect of Vitamin D3 Supplementation on Severe COVID-19: A Meta-Analysis of Randomized Clinical Trials

Effect of Vitamin D3 Supplementation on Severe COVID-19: A Meta-Analysis of Randomized Clinical Trials

The Efficacy of Multivitamin, Vitamin A, Vitamin B, Vitamin C, and Vitamin D Supplements in the Prevention and Management of COVID-19 and Long-COVID: An Updated Systematic Review and Meta-Analysis of Randomized Clinical Trials

Vitamin D, acute respiratory infections, and Covid-19: the curse of small-size randomised trials. A critical review with meta-analysis of randomised trials

Contact Info

Product

Resources

About