Effect of vitamin D supplementation on type 2 diabetes biomarkers: an umbrella of interventional meta-analyses

Musazadeh, Vali; Kavyani, Zeynab; Mirhosseini, Naghmeh; Dehghan, Parvin; Vajdi, Mahdi

doi:10.1186/s13098-023-01010-3

Cited by 17 publications

(12 citation statements)

References 89 publications

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“…The intervention led to significant improvements in energy and macronutrient intake, body weight, insulin sensitivity, and blood lipid profiles. These findings resonate with earlier studies demonstrating the benefits of vitamin D3 and probiotics on metabolic health [1][2][3][4][5][6]. The observed synergistic effect highlights the potential of combining these bioactive compounds in a dietary matrix.…”

Section: Discussionsupporting

confidence: 89%

“…Similar outcomes were observed in patients with type 2 diabetes, in which a 12-week regimen yielded substantial metabolic improvements [35]. A recent umbrella of 37 interventional meta-analyses reported that vitamin D supplementation significantly decreased fasting blood glucose, HbA1c, insulin, and HOMA, mainly in individuals with type 2 diabetes and women with gestational diabetes, as well as resulted in vitamin D dosages lower than or equal to 4000 IU [1]. The antidiabetic effects of probiotics include reducing proinflammatory cytokines via the NF-κB pathway, reducing intestinal permeability, and lowering oxidative stress [30].…”

Section: Discussionmentioning

confidence: 60%

“…To address such multifaceted physiological disruptions, researchers have turned their attention to innovative dietary interventions that leverage the combined effects of bioactive substances, including vitamin D and probiotics. Vitamin D3 has emerged as a focal point in enhancing insulin sensitivity [1], modulating lipid profiles [2], and exerting anti-inflammatory effects [3], while probiotics have been recognized for their ability to modulate the gut microbiota [4], systemic inflammation [5], and lipid metabolism [6]. A recent systematic review of seven clinical randomized controlled trials (RCTs) underscored the synergistic benefits of vitamin D and probiotic co-supplementation (lactic acid bacteria) in ameliorating chronic disease markers and improving metabolic health more effectively than either component alone [7].…”

Section: Introductionmentioning

confidence: 99%

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Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial

Papakonstantinou,

Zacharodimos,

Georgiopoulos

et al. 2024

Nutrients

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This study examined the effects of orange juice (OJ) supplemented with vitamin D3 (2000 IU) and probiotics (Lacticaseibacillus casei Shirota and Lacticaseibacillus rhamnosus GG, 108 cfu/mL) on cardiometabolic risk factors in overweight and obese adults following a Westernized-type diet. Fifty-three high-risk individuals were randomly assigned to one of two groups. Over 8 weeks, one group consumed a vitamin D3 and probiotic-enriched OJ and the other regular OJ (control). Diets remained unchanged and were documented through food diaries. Measures of metabolic and inflammatory markers and blood pressure were measured at the start and end of the study. Post-intervention, the enriched OJ group showed the following significant metabolic improvements (without changes in triglycerides, inflammation, or central blood pressure): reduced fasting insulin, peripheral blood pressure, body weight (−1.4 kg 95%CI: −2.4, −0.4), energy (−270 kcal 95%CI: −553.2, −13.7), macronutrient (dietary fat −238 kcal 95%CI: −11.9, −1.0; carbohydrates −155 kcal 95%CI: −282.4, −27.3; sugars −16.1 g 95%CI: −11.9, −1.0) intake, and better lipid profiles (total cholesterol −10.3 mg/dL 95%CI: −21.4, 0.9; LDL-C −7 mg/dL 95%CI: −13.5, −0.5). The enriched OJ led to weight loss, less energy/macronutrient consumption, improved lipid profiles, and increased insulin sensitivity after 8 weeks in those following a Westernized diet, thus indicating potential benefits for cardiometabolic risk. This study was a part of FunJuice-T2EDK-01922, which was funded by the EU Regional Development Fund and Greek National Resources.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 60%

Section: Introductionmentioning

confidence: 99%

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Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial

Papakonstantinou,

Zacharodimos,

Georgiopoulos

et al. 2024

Nutrients

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“…Hence, such AEDT-induced adaptations may be associated with the potential activation of some key molecular mechanisms responsible for regulating glucose metabolism linked to visceral and ectopic fat [ 69 , 70 ]. In summary, non-pharmacological anti-obesity agents, such as regular physical exercise, patient-centred diet and proper supplementation can be used in conjunction with prescribed medications to noticeably improve T2DM biomarkers [ 71 , 72 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis

Al-Mhanna,

Rocha-Rodriguesc,

Mohamed

et al. 2023

BMC Sports Sci Med Rehabil

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Background Lifestyle modifications involving diet and exercise are recommended for patients diagnosed with obesity and type 2 diabetes mellitus (T2DM). The purpose of this review was to systematically evaluate the effects of combined aerobic exercise and diet (AEDT) on various cardiometabolic health-related indicators among individuals with obesity and T2DM. Methodology A comprehensive search of the PubMed/Medline, Web of Science, Scopus, Science Direct, Cochrane, and Google Scholar databases was conducted for this meta-analysis. The Cochrane risk of bias tool was used to evaluate eligible studies, and the GRADE tool was used to rate the certainty of evidence. A random-effects model for continuous variables was used, and the results were presented as mean differences or standardised mean differences with 95% confidence intervals. Results A total of 16,129 studies were retrieved; 20 studies were included, and data were extracted from 1,192 participants. The findings revealed significant improvements in body mass index, body weight, waist circumference, systolic blood pressure, diastolic blood pressure, total cholesterol, triglycerides, fasting blood glucose, fasting plasma insulin, glycated hemoglobin, leptin, interleukin-6, C-reactive protein, and adiponectin (p < 0.05) compared to the standard treatment (ST) group. No significant differences were observed between the AEDT and ST groups in fat mass, hip circumference, waist-to-hip ratio, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and tumor necrosis factor-alpha. The present findings are based on low- to moderate-quality evidence. Conclusions AEDT may be a critical behavior for holistic cardiometabolic health-related benefits as a contemporary anti-obesity medication due to its significant positive impact on patients with obesity and T2DM. Nevertheless, further robust evidence is necessary to determine whether AEDT is an effective intervention for lowering cardiovascular and metabolic risk factors among individuals with obesity and T2DM.

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“…Vitamin D prevents epigenetic alterations associated with IR, and vitamin D de ciency is one of the factors accelerating IR formation [8]. Additionally, studies have con rmed that vitamin D supplementation reduce the level of metabolic parameters such as TC, LDL-C, TG, glycated hemoglobin (HbA1c), as well as decreases HOMA-IR in patients with T2DM [9][10].…”

Section: Introductionmentioning

confidence: 99%

Effects of vitamin D supplementation on metabolic parameters of women with polycystic ovary syndrome: a randomized controlled trial

Wen,

Li,

et al. 2024

Preprint

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Objective Polycystic ovary syndrome (PCOS) is a common reproductive endocrine and metabolic disease. The aim of this study was to explore the effects of vitamin D supplementation on metabolic parameters of PCOS women. Methods A total of 60 PCOS women with vitamin D deficiency or insufficiency were enrolled in this randomized controlled trial. Participants were randomized to vitamin D group (2000 IU/day) or control group. The observational parameters were measured at baseline and after treatment (4 weeks, 8 weeks and 12 weeks), including body mass index (BMI), waist to hip ratio (WHR), blood pressure, oral glucose tolerance test (OGTT) and insulin release test, and lipid metabolism parameters. Results The serum 25(OH)D concentrations at different time points after vitamin D supplementation were significantly higher than that in control group (P < 0.05). In addition, with the extension of treatment time, the serum 25(OH)D concentration gradually increased. The BMI, WHR, insulin concentrations and homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) concentrations in women of Vitamin D group after 12 weeks of treatment were significantly lower than that in women of control group (P < 0.05). Additionally, The serum insulin concentrations and HOMA-IR at different time points of OGTT, serum TG, TC and LDL-C concentrations in women of vitamin D group (obesity) were significantly lower than that in control group (obesity) (P < 0.05). The BMI, WHR, TG, TC and LDL-C concentration in women of vitamin D group (IR) were significantly lower compared with control group (IR) (P < 0.05). No significant difference was seen in metabolic parameters between vitamin D group (non-obesity) and control group (non-obesity) (P > 0.05), and these differences of metabolic parameters were also not observed between vitamin D group (non-IR) and control group (non-IR) (P > 0.05). Conclusion The findings of this study supported that vitamin D supplementation had beneficial effects on metabolic parameters of PCOS women, especially in women with obesity or IR.

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Effect of vitamin D supplementation on type 2 diabetes biomarkers: an umbrella of interventional meta-analyses

Cited by 17 publications

References 89 publications

Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial

Two-Month Consumption of Orange Juice Enriched with Vitamin D3 and Probiotics Decreases Body Weight, Insulin Resistance, Blood Lipids, and Arterial Blood Pressure in High-Cardiometabolic-Risk Patients on a Westernized Type Diet: Results from a Randomized Clinical Trial

Effects of combined aerobic exercise and diet on cardiometabolic health in patients with obesity and type 2 diabetes: a systematic review and meta-analysis

Effects of vitamin D supplementation on metabolic parameters of women with polycystic ovary syndrome: a randomized controlled trial

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