Effect of vitamin�D supplementation on polycystic ovary syndrome: A meta‑analysis

Miao, Chenyun; Fang, Xiaojie; Chen, Yun; Zhang, Qin

doi:10.3892/etm.2020.8525

Cited by 49 publications

(54 citation statements)

References 33 publications

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“…Additionally, vitamin D deficiency may be a risk factor in the development of this endocrine-metabolic pathology [41]. A meta-analysis of 11 RCTs that included 483 patients with PCOS evaluated the effect of vitamin D supplementation versus placebo [42]. The group treated with vitamin D supplements showed a reduction in insulin resistance and TC versus the placebo group.…”

Section: Vitamin D's Action On Lipid Profilementioning

confidence: 99%

Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis

et al. 2021

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Vitamin D, a crucial hormone in the homeostasis and metabolism of calcium bone, has lately been found to produce effects on other physiological and pathological processes genomically and non-genomically, including the cardiovascular system. While lower baseline vitamin D levels have been correlated with atherogenic blood lipid profiles, 25(OH)D supplementation influences the levels of serum lipids in that it lowers the levels of total cholesterol, triglycerides, and LDL-cholesterol and increases the levels of HDL-cholesterol, all of which are known risk factors for cardiovascular disease. Vitamin D is also involved in the development of atherosclerosis at the site of the blood vessels. Deficiency of this vitamin has been found to increase adhesion molecules or endothelial activation and, at the same time, supplementation is linked to the lowering presence of adhesion surrogates. Vitamin D can also influence the vascular tone by increasing endothelial nitric oxide production, as seen in supplementation studies. Deficiency can lead, at the same time, to oxidative stress and an increase in inflammation as well as the expression of particular immune cells that play a pivotal role in the development of atherosclerosis in the intima of the blood vessels, i.e., monocytes and macrophages. Vitamin D is also involved in atherogenesis through inhibition of vascular smooth muscle cell proliferation. Furthermore, vitamin D deficiency is consistently associated with cardiovascular events, such as myocardial infarction, STEMI, NSTEMI, unstable angina, ischemic stroke, cardiovascular death, and increased mortality after acute stroke. Conversely, vitamin D supplementation does not seem to produce beneficial effects in cohorts with intermediate baseline vitamin D levels.

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Section: Vitamin D's Action On Lipid Profilementioning

confidence: 99%

Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis

et al. 2021

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“…Their results were comparable to our study, except that TG levels were also significantly improved (−11.88 mg/dL; 95% CI: −17.03, to −6.73, I 2 = 0%) in our study, which is similar to the results of previous RCTs 13 – 16 and meta-analyses. 7 , 22 , 23 In Miao et al.’s study, 34 only post-treatment levels were evaluated when comparing the VitD intervention with placebo. Their results showed a marginally non-significant effect of VitD on TG (−5.59 mg/dL; 95% CI: −12.11 to 0.93, I 2 = 0%).…”

Section: Discussionmentioning

confidence: 99%

Influence of vitamin D supplementation on lipid levels in polycystic ovary syndrome patients: a meta-analysis of randomized controlled trials

Jin

Qian

et al. 2020

J Int Med Res

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Objective Observational studies have shown that circulating vitamin D (VitD) deficiency is associated with atherogenic lipid patterns among polycystic ovary syndrome (PCOS) patients. However, interventional studies have shown inconsistent results. The aim of this meta-analysis was to investigate how VitD supplementation influences lipid indices in PCOS patients. Methods The authors searched four electronic databases through August 2019 to identify randomized controlled trials (RCTs) that assessed the effect of VitD intervention on serum lipids among PCOS patients. Mean differences were generated for statistical evaluation. Results We included eight studies and performed nine comparisons across 467 participants. VitD supplementation reduced serum triglyceride levels (−11.88 mg/dL; 95% confidence interval [CI]: −17.03 to −6.73), total cholesterol (−9.09 mg/dL; 95% CI: −14.90 to −3.29), low-density lipoprotein cholesterol (−5.22 mg/dL; 95% CI: −10.32 to −0.13), and very-low-density lipoprotein cholesterol (−2.43 mg/dL; 95% CI: −3.69 to −1.17) compared with no VitD supplementation. However, high-density lipoprotein cholesterol levels showed no differences with or without VitD supplementation (−0.39 mg/dL; 95% CI: −1.39 to 0.61). Conclusions VitD supplementation improved serum lipid levels among PCOS patients, but serum high-density lipoprotein cholesterol levels were not changed. VitD intervention might benefit PCOS patients who are at high risk of an atherogenic lipid profile.

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“…Another common finding in PCOS and obesity is vitamin D deficiency (VDD) that has been reported to increase the risk of systemic infections and to impair immune response [ 38 , 39 ]. Conversely, vitamin D supplementation can prevent respiratory infections through several immunoregulatory functions including the decreased production of pro-inflammatory cytokines by innate immune system, therefore reducing the risk of cytokine storm leading to pneumonia [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

“…A series of studies have demonstrated that VDD might be a causal factor in the pathogenesis of IR and the metabolic syndrome in PCOS [ 40 ]. Indeed, a relatively high prevalence of VDD is observed among women with PCOS (approximately 67–85 % PCOS women) and compared with the general population, the prevalence of VDD is relatively higher in PCOS patients [ 38 ]. Additionally, positive associations of VDD with some well-known comorbidities of PCOS including T2DM, IR, metabolic syndrome, and cardiovascular diseases, are reported [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

“…Indeed, a relatively high prevalence of VDD is observed among women with PCOS (approximately 67–85 % PCOS women) and compared with the general population, the prevalence of VDD is relatively higher in PCOS patients [ 38 ]. Additionally, positive associations of VDD with some well-known comorbidities of PCOS including T2DM, IR, metabolic syndrome, and cardiovascular diseases, are reported [ 38 ]. This is supported by the fact that the vitamin D receptor (VDR) regulates more than 3% of the human genome, including genes that are crucial for glucose metabolism [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

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Coronavirus Disease 2019 (SARS-CoV-2) and polycystic ovarian disease: Is there a higher risk for these women?

Morgante

Troìa

Leo

2021

The Journal of Steroid Biochemistry and Molecular Biology

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Highlights PCOS women could be more exposed to SARS-CoV-2 infection. Hyperandrogenic PCOS women activity of Androgen Receptor is very high, and this would lead to a greater transcription of the TMPRSS2 gene. Insulin resistance and uncontrolled glycaemia were reported as significant predictors of severity and deaths in patients infected with viruses. Obesity of PCOS women could contribute to both diabetic and cardiovascular risk of COVID-19. It could be hypothesized that VDD could take part to the link between obesity, PCOS and increased complications and mortality due to COVID-19. PCOS women had a dysbiotic gut mirobiota that is a common feature underlying health problem associated with inflammation and other disorders.

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Effect of vitamin�D supplementation on polycystic ovary syndrome: A meta‑analysis

Cited by 49 publications

References 33 publications

Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis

Vitamin D and Its Role in the Lipid Metabolism and the Development of Atherosclerosis

Influence of vitamin D supplementation on lipid levels in polycystic ovary syndrome patients: a meta-analysis of randomized controlled trials

Coronavirus Disease 2019 (SARS-CoV-2) and polycystic ovarian disease: Is there a higher risk for these women?

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