Effect of vitamin D supplementation in type 2 diabetes patients with pulmonary tuberculosis

The interaction effects of aerobic exercise training and vitamin D supplementation on plasma lipid profiles and insulin resistance in ovariectomized rats

“…These results suggest that the serum concentration of TG is inversely associated with the serum level of 25(OH) D [55]. In contrast, Kota and colleagues showed no relationship between serum levels of 25(OH) D and TG or HDL cholesterol in healthy subjects [56]. It was suggested that vitamin D has both direct and indirect effects on modifying the lipid profile and that the effect of vitamin D on decreasing serum levels of TG, TC and LDL may occur through regulatory action that increases the activity of lipoprotein lipase in adiposity [57].…”

Nutritional supplements for people being treated for active tuberculosis

“…One trial was stopped early when antiretrovirals became locally available (Semba 2007 MWI). Eleven trials excluded people with HIV infection (Hanekom 1997 ZAF; Paton 2004 SGP; Pérez-Guzmán 2005 MEX; Nursyam 2006 IDN; Armijos 2010 MEX; Jahnavi 2010 IND; Paliliewu 2013 IDN; Lodha 2014 IND; Daley 2015 IND; Farazi 2015 IRN; Mily 2015 BGD), and eight trials did not mention HIV infection (Morcos 1998 EGY; Karyadi 2002 IDN; Seyedrezazadeh 2006 IRN; Martins 2009 TLS; Pakasi 2010 IDN; Kota 2011 IND; Ginawi 2013 IND; Singh 2013 IND). …”

High-dose vitamin D3 in adults with pulmonary tuberculosis: a double-blind randomized controlled trial

“…These latter 2 RCTs used a vitamin D 3 dosing regimen of 2.5 mg orally at baseline, which was repeated at weeks 2, 4, and 6, for a total dose of 10 mg (400,000 IU). Thus, our dosing regimen was 3.5-fold higher than in these studies (35 mg or 1.4M IU over 16 wk), and the 25(OH)D concentrations achieved were considerably higher than the concentrations observed in those trials (19,23) Overall, published data on the impact of adjunctive vitamin D administration in patients with pulmonary tuberculosis are difficult to interpret because of uncertain random assignment (17), varying vitamin D doses and dosing schedules (18)(19)(20)(21)(22), the absence of measured blood 25(OH)D concentrations (17,21), the inability of the vitamin D dose used to increase serial blood 25(OH)D concentrations (18), a lack of data on the impact of vitamin D on sputum culture conversion (17,18,20,22), and/or missing data (23). Our study differed from most previous reports in that we incorporated serial sputum culture results, semiquantitative sputum smear data, baseline vitamin D status, and the presence of cavitation on chest radiographs in our analysis, and we used a higher dose of vitamin D 3 (Figure 2A).…”

“…vitamin D may be difficult to interpret because of various aspects of study designs, the endpoints chosen, missing data, a lack of measurement of 25-hydroxyvitamin D [25(OH)D] (21), and varying doses of vitamin D (18)(19)(20)(21)(22)(23), which, in some studies, failed to increase blood 25(OH)D concentrations (18). In the current study, we tested the hypothesis that adjunctive highdose vitamin D 3 administration, which was designed to safely increase plasma 25(OH)D concentrations into a sustained supraphysiologic range, would significantly enhance the clearance of Mycobacterium tuberculosis (Mtb) from sputum over time in adults with newly diagnosed pulmonary tuberculosis disease in Tbilisi, Georgia.…”

“…Because of the pleiotropic effects of vitamin D on immunity, several randomized clinical trials (RCTs) of vitamin D supplementation in patients with pulmonary tuberculosis disease have been performed (17)(18)(19)(20)(21)(22)(23). Unfortunately, the efficacy of adjunctive 1 Supported in part by NIH grants UL1 TR000454 (to the Atlanta Clinical and Translational Science Institute), K24 DK096574 (to TRZ), D43 TW007124 (to HMB), D43 TW001042 (to CDR), K23 AR054334 (to VT), K23 AI103044 (to RRK), and T32 DK007298-32S1 and K01 DK102851 (to JAA) and the Emory University Global Health Institute (to TRZ, VT, HMB, CD, and RRK).…”