Effect of vitamin derivatives on gelation rate and gel strength of methylcellulose

Kim, Min Hee; Park, Hanna; Shin, Ji Youn; Park, Won Ho

doi:10.1016/j.carbpol.2018.05.042

Cited by 16 publications

(5 citation statements)

References 31 publications

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“…Following complete gelation, the compressive strength was observed at the crosshead speed of 1 mm/min. The maximum compressive strength and compression resilience of the PGADA hydrogel were characterized by five cycle loading–unloading compression tests to a compression strain of 80%. , …”

Section: Methodsmentioning

confidence: 99%

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Enzymatically Cross-Linked Poly(γ-glutamic acid) Hydrogel with Enhanced Tissue Adhesive Property

Kim

Lee

et al. 2020

ACS Biomater. Sci. Eng.

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Enzymatic cross-linking of polymer–catechol conjugates in the presence of horseradish peroxidase (HRP) and H2O2 has emerged as an important method to fabricate in situ-forming, injectable hydrogels. Subsequently, tissue adhesion studies using catechol-containing polymers were extensively reported. However, because of the presence of numerous variables such as polymer concentration, oxidizing agent/enzyme, and stoichiometry, the design of the polymer with optimized tissue adhesive property is still challenging. In this study, a poly(γ-glutamic acid) (γ-PGA)-dopamine (PGADA) conjugate was synthesized, and in situ hydrogels were fabricated via enzymatic cross-linking of a catechol moiety. To optimize the tissue adhesive property of the PGADA hydrogel, the effect of various factors, such as polymer concentration, catechol substitution degree (DS), HRP concentration, and H2O2 content, on the gelation behavior and mechanical strength was investigated. The gelation behavior of PGADA hydrogels was characterized using a rheometer and rotational viscometer. Also, the possibility of its use as a tissue adhesive was examined by evaluating the tissue adhesion strength in vitro and ex vivo.

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Section: Methodsmentioning

confidence: 99%

“…The maximum compressive strength and compression resilience of the PGADA hydrogel were characterized by five cycle loading−unloading compression tests to a compression strain of 80%. 46,47 2.9. In Vitro Tissue Adhesion Property.…”

Section: Methodsmentioning

confidence: 99%

Enzymatically Cross-Linked Poly(γ-glutamic acid) Hydrogel with Enhanced Tissue Adhesive Property

Kim

Lee

et al. 2020

ACS Biomater. Sci. Eng.

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“…When the temperature is lower than LCST, MC forms hydrogen bonds with water molecules in the solution and shows a flowing viscous liquid. However, when the temperature is above LCST, the hydrogen bonds break, and -OCH 3 is exposed to the solution, and the enhanced hydrophobic effect causes local aggregation and contraction of polymer molecular chains to form a cross-connected network structure, and the state changes from sol to gel ( Kim et al, 2018a ; Kim et al, 2018b ).…”

Section: Types Of Thermosensitive Nanomaterialsmentioning

confidence: 99%

“…Meanwhile, in solution, MC molecules containing phosphate ions form stable hydrogen bonds with water molecules. In summary, due to the existence of salting-out effect, the gel speed and mechanical properties of the MC gel are improved, while its injectability maintains an appropriate maximum force ( Kim et al, 2018b ). Moreover, Park et al used the precursor salt of CaP to induce the salting-out effect and prepared a MC thermosensitive nanomaterial based on CaP nanoparticles by the one-pot method.…”

Section: Types Of Thermosensitive Nanomaterialsmentioning

confidence: 99%

Nanomaterials based on thermosensitive polymer in biomedical field

et al. 2022

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The progress of nanotechnology enables us to make use of the special properties of materials on the nanoscale and open up many new fields of biomedical research. Among them, thermosensitive nanomaterials stand out in many biomedical fields because of their “intelligent” behavior in response to temperature changes. However, this article mainly reviews the research progress of thermosensitive nanomaterials, which are popular in biomedical applications in recent years. Here, we simply classify the thermally responsive nanomaterials according to the types of polymers, focusing on the mechanisms of action and their advantages and potential. Finally, we deeply investigate the applications of thermosensitive nanomaterials in drug delivery, tissue engineering, sensing analysis, cell culture, 3D printing, and other fields and probe the current challenges and future development prospects of thermosensitive nanomaterials.

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“…With the call for cost reduction and the protection of the environment, the preparation of gels using natural polyhydroxy materials has become a hot research topic. Cellulosebased hydrogel combines the biodegradability and the large availability of cellulose in nature [15,27,28], along with the smart sensitive behavior and the low cost of cellulose derivatives, which have various ranges of applications. In this study, we used methylcellulose, sodium polyacrylate, and magnesium chloride as raw materials to prepare a thermosensitive hydrogel.…”

Section: Introductionmentioning

confidence: 99%

Experimental Study on Thermosensitive Hydrogel Used to Extinguish Class A Fire

Huang

Sheng

et al. 2021

Polymers

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Hydrogels are crosslinked polymers that become fully swollen when placed in aqueous environments. They are widely used in the field of firefighting because they can remarkably increase the viscosity and wettability of water. In this study, a thermosensitive hydrogel used to effectively suppress class A fire was synthesized by using methylcellulose, sodium polyacrylate, and magnesium chloride. The structure, surface activity and viscosity of the hydrogel were characterized. Fire extinguishing performance was evaluated based on small-scale and large-scale experiments. The results showed that a phase transition of the hydrogel occurred when the temperature rose from 50 °C to 80 °C. After the phase transition, the hydrogel showed a higher viscosity and lower surface tension, which was conducive to attach to the surface of the burning material and acting as an effective barrier to isolate oxygen. The small-scale fire extinguishing tests indicated that the concentration of the hydrogel solution has an eminent influence on fire extinguishing performance. The optimum concentration for extinguishing performance was around 6 wt%. The large-scale experiments demonstrated that the fire-extinguishing performance of this thermosensitive hydrogel was superior to the two other commercial water-based fire extinguishing agents, as it prevented re-ignition highly efficiently.

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Effect of vitamin derivatives on gelation rate and gel strength of methylcellulose

Cited by 16 publications

References 31 publications

Enzymatically Cross-Linked Poly(γ-glutamic acid) Hydrogel with Enhanced Tissue Adhesive Property

Enzymatically Cross-Linked Poly(γ-glutamic acid) Hydrogel with Enhanced Tissue Adhesive Property

Nanomaterials based on thermosensitive polymer in biomedical field

Experimental Study on Thermosensitive Hydrogel Used to Extinguish Class A Fire

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