Effect of Vitamin E and omega 3 fatty acids in type 2 diabetes mellitus patients

Abstract

Diabetes mellitus (DM) and its complications have been implicated in hyperglycemia-induced oxidative stress. Antioxidants can improve glycemic control, lipid profile, and cognitive functions. We assessed the effect of Vitamin E and omega 3 fatty acids (OFA) on the above parameters. One hundred patients with type 2 DM receiving metformin 500 mg and glimepiride 1 mg were randomized to receive add-on therapy of Vitamin E 400 mg or OFA once daily for 12 weeks and the third group served as control. Fasting blood sugar (FBS), postprandial blood sugar (PPBS), glycated hemoglobin (HbA1c), body mass index (BMI), waist-hip ratio (WHR), lipid profile, and mini-mental state examination were done at baseline and 12 weeks. Eighty-seven patients completed the study. A significant reduction in FBS, PPBS, and HbA1c was observed in all the three groups at 12 weeks. There was significant reduction in total cholesterol and triglycerides (TG) in patients receiving either of the antioxidants and also significant reduction in low-density lipoprotein in patients receiving OFA at 12 weeks compared to baseline. BMI and WHR were significantly increased in control group. Intergroup analysis showed that in patients receiving Vitamin E and OFA, the reduction of FBS, PPBS, and HbA1c were similar. The patients receiving OFA had significant reduction in TG compared to control. There was no significant effect on cognitive function. Vitamin E and OFA had beneficial effects on lipid profile and anthropometric measurements; however, the glycemic control was similar to the patients in control group.

Pecularities of treatment of elderly patients with type 2 diabetes mellitus

“…В данный момент имеются данные об отсутствии необходимости скрининга дефицита В 12 среди пациентов старшей возрастной группы в связи с отсутствием его клинический проявлений. В литературе упоминаются исследования целесо образности рутинного назначения поливитаминных комплексов среди пациентов пожилого возраста с СД2, однако данных об эффективности их применения не получено [20,21]. Исследования в отношении эффективности полиненасыщенных жирных кислот продемонстрировали противоречивые результаты [22,23].…”

Management of Type 2 Diabetes Mellitus in Elderly Patients with Frailty and/or Sarcopenia

“…The relationship between the intake of these supplements and frailty has been studied in some observational studies [ 46 ]. There have been few clinical trials with supplements of these vitamins, without positive results [ 47 , 48 ]. Vitamin supplementation could have positive effects on cognitive function in patients with subclinical vitamin deficiency, but this should be investigated in future studies with elderly patients with diabetes as the evidence published is not clear.…”

Fruits and Vegetables in the Management of Underlying Conditions for COVID-19 High-Risk Groups

“…Adequate supply of vitamin C and proper glucose control are essential [ 96 ]. Vitamin E, a strong antioxidant that has been shown to reduce the risk of long-term complications associated with diabetes [ 97 ]. Zinc has been shown to have an effective role in protecting against long-term complications from diabetes especially for the liver [ 98 ].…”