Effect of vitamin E supplementation on blood pressure: a systematic review and meta-analysis

Emami, Mohammad Reza; Safabakhsh, Maryam; Alizadeh, Shahab; Asbaghi, Omid; Khosroshahi, Mohammad Zeinali

doi:10.1038/s41371-019-0192-0

Cited by 38 publications

(33 citation statements)

References 40 publications

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“…The mean standing SBP was only slightly decreased on R0; however, this decrease in standing SBP was observed in the nutritional intervention group, not the control group. This could have been most likely a result of the blood pressure lowering effect of selenium 36 , vitamin E 37 , and omega-3-acid ethyl ester 38 .…”

Section: Discussionmentioning

confidence: 99%

Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization

Tremblay

Verma

et al. 2020

Sci Rep

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To understand fundamental mechanisms associated with post-flight orthostatic intolerance we investigated the interaction between the cardiovascular and postural functions before and after 60 days of head down bedrest (HDBR). Twenty healthy young males (35.0 ± 1.7 years) were subjected to 60-day HDBR at 6˚ to simulate spaceflight-induced fluid shifts. A supine-to-stand (STS) test was conducted to evaluate cardio-postural control before and after (R) HDBR while an assessment of cardiovascular function was performed during HDBR. Beat-to-beat heart period, systolic blood pressure, and electromyography impulses were derived for wavelet transform coherence and causality analyses of the cardio-postural control and used to assess changes in the muscle-pump baroreflex. During quiet stand of the STS test, compared to baseline, heart rate was 50% higher on the day of exit from bedrest (R0) and 20% higher eight days later (R8). There was a 50% increase in deoxygenated hemoglobin on R0 and R8. Leg muscle activity reduced, and postural sway increased after HDBR. Causality of the muscle-pump baroreflex was reduced on R0 (0.73 ± 0.2) compared to baseline (0.87 ± 0.2) with complete recovery by R8. The muscle-pump baroreflex also had decreased gain and fraction time active following HDBR. Overall, our data show a significantly impaired muscle-pump baroreflex following bedrest. Spaceflight-induced weightlessness produces time-dependent physiological adaptation responses 1-3. Once adapted to weightlessness, many responses become inappropriate upon return to a gravitational environment. The resulting physiological deconditioning could pose a serious challenge in the event of a critical post-landing situation requiring rapid escape from a spacecraft. Orthostatic intolerance after spaceflight remains a health and safety concern for astronauts, not just on landing day but also in the days of recovery 4. Similar physiological deconditioning is seen following long lasting bedrest confinements (e.g. in young persons participating in head down bedrest studies, or in older persons due to chronic diseases or after falls and falls-related injuries) 5. Gravitational effects on the cardiovascular system during upright posture (orthostatic loading) induce a decrease in blood pressure which, if not compensated for, will cause loss of consciousness 6. Baroreflex plays an essential role in maintaining blood pressure equilibrium under orthostatic loading. In regards to the arterial baroreflex, two processes exist in tandem: one in which blood pressure alters baroreceptor output and hence heart rate and vasomotor tone 7-9 ; and, a second in which changes in heart rate and vasomotor tone alters blood pressure-the former a baroreflex (feed-back) and the latter a non-baroreflex (feed-forward) control of blood pressure 10. Similarly, conscious movement could place a person in a position of instability, which would require post-movement adjustment to maintain an upright stance. Therefore, any change in body position (feed-forward) must be accompanied with ...

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Section: Discussionmentioning

confidence: 99%

Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization

Tremblay

Verma

et al. 2020

Sci Rep

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“…Another clinical trial, also reported that supplementation with 200 IU/day for 27 weeks showed a considerable decrease in the levels of SBP (−24%) and DBP (−12.5%) as compared to placebo in mild hypertensive participants [119]. Lately, Emami and his colleagues [120] conducted a systemic review and meta-analysis including 18 trials with 839 participants and concluded that subjects supplemented with vitamin E showed a significant reduction in SBP (−3.4 mm Hg) as compared to a placebo, but no changes in DBP or MBP. Taken together, Vit E administration (for the long term), could help in improving overall vascular health (enhance NO bioavailability), but is more effective in elderly hypertensive and severe gestational hypertensive subjects.…”

Section: Clinical Evidencementioning

confidence: 97%

“…Vitamin E is rich in nuts (almonds, peanut, cashew), seeds oils (sunflower, soybean), raisin, spinach, red bell pepper [118]. Although many existing data suggest that supplementation of Vitamin E could positively regulate the blood pressure [119,120], still few studies indicated that no or very less impact of Vitamin E on blood pressure [121,122]. Overall, the normal levels of Vit E levels are maintained by supplementing 10-15 mg (RDA) of Vit E through consuming Vit E rich foods as mentioned above to improve vascular function.…”

Section: Vitamin E or Tocopherolmentioning

confidence: 99%

Impact of Micronutrients on Hypertension: Evidence from Clinical Trials with a Special Focus on Meta-Analysis

et al. 2021

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Hypertension (HT) is one of the pivotal risk factors for various detrimental diseases like cardiovascular diseases (CVDs), cerebrovascular disease, and renal dysfunction. Currently, many researchers are paying immense attention to various diet formula (dietary approach) with a special focus on micro and macronutrients along with modified lifestyle and standard anti-hypertensive drugs. Micronutrients (minerals/vitamins) play a central role in the regulation of blood pressure (BP) as they aid the function of macronutrients and also improve the anti-hypertensive functions of some anti-hypertensive agents. Even though several studies have demonstrated the beneficial effects of micronutrients on controlling BP, still some ambiguity exists among the nutritionists/doctors, which combination or individual mineral (dietary approach) contributes to better BP regulation. Therefore, this critical review article was attempted to delineate the underlying role of micronutrients (minerals and vitamins) for the management and prevention or delaying of HT and their related complications with strong affirmation from clinical trials as well as its mechanism of controlling BP. Moreover, the major source and recommended daily allowance (RDA) of various micronutrients are included in this review for guiding common readers (especially HT subjects) and dieticians to choose/recommend a better micronutrient and their combinations (other nutrients and standard anti-hypertensive drugs) for lowering the risk of HT and its related co-morbid conditions like CVDs.

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“…Dietary folate and vitamin C, as well as plasma ascorbic acid, have been found to be inversely associated with blood pressure in observational studies [66,67]. Multiple nutrition components have been reported to be effective at lowering blood pressure including vitamin C [68], -D [54], -E [69], -B6 [70], -B12, folate [71,72], niacin [73], thiamine [74], riboflavin [75], magnesium [58], iron [76], calcium [77] and CoQ10 [78]. Consistently, in the present study, significant reduction of SBP was observed in unadjusted analysis (119.12 ± 2.96 vs. 127.44 ± 0.73 mmHg, p=0.011) ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study

Jin¹,

Maddela²,

Sinnott³

2020

JFNS

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Effect of vitamin E supplementation on blood pressure: a systematic review and meta-analysis

Cited by 38 publications

References 40 publications

Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization

Cardio-postural interactions and muscle-pump baroreflex are severely impacted by 60-day bedrest immobilization

Impact of Micronutrients on Hypertension: Evidence from Clinical Trials with a Special Focus on Meta-Analysis

The Effects of a Multivitamin, Multimineral, and Multiantioxidant Supplement on Cardio-Metabolic Risk Biomarkers: A Cross-Sectional Study

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