Effect of vitamin E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers and hormonal functions in PCOS (polycystic ovary syndrome): a systematic review and meta‐analysis

Tefagh, Ghazale; Payab, Moloud; Qorbani, Mostafa; Sharifi, Farshad; Sharifi, Yasaman; Shirvani, Mahbubeh Sadat Ebrahimnegad; Pourghazi, Farzad; Atlasi, Rasha; Shadman, Zhaleh; Rezaei, Nafiseh; Mohammadi-Vajari, Erfan; Larijani, Bagher; Ebrahimpur, Mahbube

doi:10.1038/s41598-022-09082-3

Cited by 21 publications

(16 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, supplementation with vitamin E ameliorated LDL resistance to oxidation propagation [ 74 ]. Although research results are inconsistent, some studies indicated that vitamin E supplementation might improve selected parameters of the lipid profile [ 46 , 50 , 75 ]. Few large-scale studies of dietary vitamin E intake showed a positive effect in reducing the risk of coronary heart disease in both men and women [ 76 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review

et al. 2022

View full text Add to dashboard Cite

Menopause is a physiological change in any woman. Nevertheless, its symptoms could be difficult to accept, and hormone therapy can be sometimes unattractive or contraindicated. Vitamin E components are phytoestrogens, so they are believed to be useful in some indications including menopause. This review aimed to assess the available evidence on the effectiveness of vitamin E in alleviating menopausal symptoms. The Pubmed/MEDLINE, Cochrane Library and Scopus databases were screened. All types of studies that assessed the effectiveness of vitamin E in alleviating menopausal symptoms were included. The PICO question was: “How does vitamin E supplementation affect menopausal symptom occurrence?” The PROSPERO ID number of this review is CRD42022328830. After quality assessment, 16 studies were included in the analysis. The studies were divided into three groups in which the influence of vitamin E on the genital syndrome of menopause, vasomotor symptoms and vascular and metabolic changes were assessed. Vitamin E influences postmenopausal hot flashes, vascular modulation, plasma lipid profile level and vaginal changes. Compared to vitamin E, estrogen administration leads to better clinical effects. Nevertheless, vitamin E might serve as additive to hormone therapy and its alternative in women with contraindications to estrogens. More quality data are necessary to draw final conclusions.

show abstract

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Studies of RCT [ 52 , 53 ] demonstrated that a high intake of fish improved blood lipid profiles, including TG and HDLC. In addition, VE supplementation resulted in statistically significant improvements in TG [ 54 ]. On the other hand, observational studies have reported detrimental effects from a high-carbohydrate diet on HDLC and TG levels in Korean [ 32 , 55 ] and U.S. women [ 32 ] but not in U.S. men [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary Patterns Derived from Reduced Rank Regression Are Associated with the 5-Year Occurrence of Metabolic Syndrome: Aichi Workers’ Cohort Study

Yatsuya

Wang

et al. 2022

Nutrients

View full text Add to dashboard Cite

The aim of the present study was to derive dietary patterns to explain variation in a set of nutrient intakes or in the measurements of waist circumference (WC) and fasting blood glucose (FBG) using reduced rank regression (RRR) and to prospectively investigate these patterns in relation to the risk of developing metabolic syndrome (MetS) and its components during the follow-up. The study participants were comprised of 2944 government employees aged 30–59 years without MetS. RRR was applied with 38 food groups as predictors and with two sets of response variables. The first set included intake of putatively beneficial nutrients, and the first factor retained was named the Healthy Dietary Pattern (HDP). The second one included baseline WC and FBG, and the first factor was named the Unhealthy Dietary Pattern (UHDP). Multivariable Cox proportional hazard model was used to estimate hazard ratio and 95% confidence intervals with adjustments for age, sex, total energy consumption and other potential confounders. During the 5-year median follow-up, we ascertained 374 cases of MetS. The HDP score was inversely associated with the incidence of MetS (p-trend = 0.009) and hypertension (p-trend = 0.002) and marginally significantly associated with elevated triglyceride and decreased high-density lipoprotein cholesterol (p-trend = 0.08). The UHDP score was linearly positively associated with the incidence of MetS and all its components (all p-trend < 0.05). Both the HDP and UHDP predicted the development of MetS and its components.

show abstract

“…In recent years, the use of natural compounds and herbs in the PCOS women (Manouchehri et al, 2022). Intervention with vitamin D (Miao, Fang, Chen, & Zhang, 2020), vitamin E (Tefagh et al, 2022), omega-3 fatty acids (J. A. G. Tosatti et al, 2021), coenzyme Q10 (Zhang et al, 2022), curcumin (Chien & Chang, 2021) and phytoestrogens (Najafi et al, 2018) has also been proposed in recent systematic review of clinical trials and potentially has been able to improve the condition of PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

“…A recent systematic review stated that natural herbs such as aloe vera and chamomile improve fertility; Vitex agnus‐castus and octane reduce hirsutism; liquorice, ginseng, cinnamon, myo‐inositol improve insulin sensitivity; and Stachys lavandulifolia and fennel are effective in endometrial status in PCOS women (Manouchehri et al, 2022). Intervention with vitamin D (Miao, Fang, Chen, & Zhang, 2020), vitamin E (Tefagh et al, 2022), omega‐3 fatty acids (J. A. G. Tosatti et al, 2021), coenzyme Q10 (Zhang et al, 2022), curcumin (Chien & Chang, 2021) and phytoestrogens (Najafi et al, 2018) has also been proposed in recent systematic review of clinical trials and potentially has been able to improve the condition of PCOS patients.…”

Section: Discussionmentioning

confidence: 99%

The effects of flaxseed or its oil supplementations on polycystic ovary syndrome: A systematic review of clinical trials

Emamat

Boushehri

Eslami

et al. 2022

Phytotherapy Research

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders around the world that can endanger reproductive, metabolic, and psychological health in women. Flaxseed is considered as a functional food which provides remarkable amounts of α‐linolenic acid (ALA), phytosterogenic lignans, and dietary fibers. This study aimed to investigate the effectiveness of flaxseed or its oil supplementation on PCOS patients. We systematically searched all published randomized clinical trials indexed in PubMed, Scopus, and Google Scholar databases from inception up to May 2022. Intended exposure and outcome were flaxseed or its oil and metabolic, anthropometric, and hormonal status of women with PCOS, respectively. Initial search via related keywords revealed 69 articles. After excluding duplicates, title and abstract of 55 remaining papers were screened. Fourteen papers were obtained for full text screening. Finally, nine clinical trials published between 2011 and 2021 were included in qualitative synthesis. Based on the results of the present systematic review, we suggest that flaxseed supplementation has the potential to improve metabolic, hormonal, and anthropometric parameters in women with PCOS. However, we also deduce that due to the scarcity of high‐quality studies, additional studies need to be conducted in order to derive a solid conclusion.

show abstract

Effect of vitamin E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers and hormonal functions in PCOS (polycystic ovary syndrome): a systematic review and meta‐analysis

Cited by 21 publications

References 34 publications

The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review

The Effect of Vitamin E Supplementation in Postmenopausal Women—A Systematic Review

Dietary Patterns Derived from Reduced Rank Regression Are Associated with the 5-Year Occurrence of Metabolic Syndrome: Aichi Workers’ Cohort Study

The effects of flaxseed or its oil supplementations on polycystic ovary syndrome: A systematic review of clinical trials

Contact Info

Product

Resources

About