Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials

Abstract

C-reactive protein (CRP), a marker of chronic inflammation, has a major role in the etiology of chronic disease. Vitamin E may have anti-inflammatory effects. However, there is no consensus on the effects of vitamin E supplementation on CRP levels in clinical trials. The aim of this study was to systematically review randomized controlled trials (RCTs) that report on the effects of vitamin E supplementation (α- and γ-tocopherols) on CRP levels. A systematic search of RCTs was conducted on Medline and EMBASE through PubMed, Scopus, Ovid and Science Direct, and completed by a manual review of the literature up to May 2014. Pooled effects were estimated by using random-effects models and heterogeneity was assessed by Cochran's Q and I(2) tests. Subgroup analyses and meta-regression analyses were also performed according to intervention duration, dose of supplementation and baseline level of CRP. Of 4734 potentially relevant studies, only 12 trials met the inclusion criteria with 246 participants in the intervention arms and 249 participants in control arms. Pooled analysis showed a significant reduction in CRP levels of 0.62 mg/l (95% confidence interval = -0.92, -0.31; P < 0.001) in vitamin E-treated individuals, with the evidence of heterogeneity across studies. This significant effect was maintained in all subgroups, although the univariate meta-regression analysis showed that the vitamin E supplementation dose, baseline level of CRP and duration of intervention were not the sources of the observed heterogeneity. The results of this meta-analysis suggest that supplementation with vitamin E in the form of either α-tocopherol or γ-tocopherol would reduce serum CRP levels.

Maternal biomarker patterns for metabolism and inflammation in pregnancy are influenced by multiple micronutrient supplementation and associated with childrens’s biomarker patterns and nutritional status at 9-12 years of age in Lombok, Indonesia

“…Moreover, MMN supplementation interacted with maternal biomarkers PC at baseline to influence biomarkers PC at post-supplementation. Previous studies have reported that vitamin C and E supplementation reduced CRP concentrations [36,46], and vitamin D influenced serum leptin and adiponectin concentrations [47].…”

Short‐Term High‐Dose Vitamin E to Prevent Contrast Medium–Induced Acute Kidney Injury in Patients With Chronic Kidney Disease Undergoing Elective Coronary Angiography: A Randomized Placebo‐Controlled Trial

“…These findings confirm that inflammatory mechanisms may be involved in the pathogenesis of CIAKI incidence. It may be speculated that the effects of vitamin E are applied, in some part, through attenuation of inflammation in addition to scavenging free oxygen radicals . A recent meta‐analysis that evaluated the effects of vitamin E–coated dialyzer on oxidative status and inflammation revealed that dialyzer membrane containing vitamin E decreased inflammatory markers, reflecting the anti‐inflammatory property of vitamin E …”

MOTA: Network-Based Multi-Omic Data Integration for Biomarker Discovery

“…As shown in Figure 2, α-TOH is also connected with C-reactive protein (CRP, P02741), which is a marker of inflammation. Several previous studies have shown the anti-inflammatory effect of α-TOH [26,27] and indicated a biological relationship between these two proteins. These examples show that MOTA has a promising capability to pinpoint disrupted regulatory relationships between biomolecules by a pathophysiological condition and highlight important risk molecules.…”