Effect of Vitamin E Supplementation on the Haemagglutination Inhibitor Titre Vaccinated against Newcastle Disease in T-2 Toxin Challenged Chickens

Kovács-Weber, Mária; Fodor, József; Balogh, Krisztián; Wagner, Isabella Coimbra; Erdélyi, Márta; Mézes, Miklós

doi:10.2754/avb200877010045

Cited by 9 publications

(7 citation statements)

References 15 publications

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“…Fall in GMT of HI antibody titers in all groups on day 28 onward might be due to the suppression of humoral immunity against NDV with IBD (because in this study ND and IBD vaccines were used on the same day [18]. The results of this study are also in correlation with the earlier findings [19]. Vitamin C having antioxidant property protects immature lymphocytes from damage by free radicals and enhances immune response which results in increases antibody titers against ND virus upon supplementation with different levels of ascorbic acid [20,21].…”

Section: Antibody Titers Against Ndsupporting

confidence: 85%

Effects of Vitamins E and C Supplementation on the Immune Response of Broiler Chicks

Bhatti¹,

Hussain²,

Mukhtār³

et al. 2016

J Antivir Antiretrovir

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The present study was done to know the effects of supplementations of vitamin C and E on humoral immune response against Newcastle Disease (ND) and Infectious Bursal Disease (IBD) and on lymphoid organs in broiler birds. One hundred and twenty day old chicks were purchased from a local hatchery and were reared in an open house shed. On day 5 th all the chick divided randomly into 4 groups A, B, C and D (30 birds in each). On the day 5 th and 11 th , the chicks were vaccinated against ND and Disease IBD. Booster doses of both vaccines were given on day 28. The chicks were offered Vitamin E (600 mg l -1 ), Vitamin C (600 mg l -1 ) and Vitamin E+C (300 mg l -1 each), for 5 consecutive days in drinking water on day 5 and 28. Weekly serum Hemagglutination Inhibition (HI) antibody titers against ND virus, total body weight, feed conversion ratio (FCR) and weight of lymphoid organs were recorded until the day 49. Geometric mean HI antibody titers against ND remained maximum in group C. Statistical analysis revealed a non significant (P<0.05) differences among the various treatment groups in weight gain. At day 49, the total weight gain was maximum in group C (2196.0 gm) followed by group A (2155.0 g), group B (2146 g) and group D (2094 gm). The feed conversion ratio was the best in the group B (1.66) followed by group C (1.69) with a non significant difference. From the study, it was concluded that the combined effect of Vitamin E+C was better as compared to separate supplementation of Vitamin E and Vitamin C.

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Section: Antibody Titers Against Ndsupporting

confidence: 85%

Effects of Vitamins E and C Supplementation on the Immune Response of Broiler Chicks

Bhatti¹,

Hussain²,

Mukhtār³

et al. 2016

J Antivir Antiretrovir

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“…Similarly, immunmodulatory effects were observed in an experiment with 23 day old broiler cockerels (n = 20 per dose) exposed to 2.35 or 4.18 mg/kg T-2 toxin in feed for 14 days (Weber et al, 2006). Further investigations of the same group showed that oral application of vitamin E increased antibody formation against Newcastle disease in animals, an effect which could not be suppressed by exposure to 2.35 mg/kg T-2 toxin in diet (Weber et al, 2008). Further investigations of the same group showed that oral application of vitamin E increased antibody formation against Newcastle disease in animals, an effect which could not be suppressed by exposure to 2.35 mg/kg T-2 toxin in diet (Weber et al, 2008).…”

Section: Poultrymentioning

confidence: 98%

Scientific Opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxin in food and feed

2011

EFSA Journal

281

102

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T-2 toxin and HT-2 toxin are mycotoxins produced by various Fusarium species. The European Commission asked EFSA for a scientific opinion on the risk to human and animal health related to the presence of T-2 and HT-2 toxin in food and feed. A total of 20,519 results for the sum of T-2 and HT-2 toxins in food, feed and unprocessed grains, collected in 2005-2010 from 22 European countries, were used in the evaluation. The highest mean concentrations for the sum of T-2 and HT-2 toxins were observed in grains and grain milling products, notably in oats and oat products. Grains and grain-based foods, in particular bread, fine bakery wares, grain milling products, and breakfast cereals, made the largest contribution to the sum of T-2 and HT-2 toxin exposure for humans. T-2 toxin is rapidly metabolised to a large number of products, HT-2 toxin being a major metabolite. Pigs are amongst the most sensitive animals towards the effects of T-2 toxin, the most sensitive endpoints being immunological or haematological effects. Using these data and a benchmark dose analysis the Panel on Contaminants in the Food Chain established a group tolerable daily intake (TDI) of 100 ng/kg b.w. for the sum of T-2 and HT-2 toxins. Estimates of chronic human dietary exposure to the sum of T-2 and HT-2 toxins based on the available occurrence data are below the TDI for populations of all age groups, and thus not a health concern. For ruminants, rabbits and farmed fish the estimated exposures to the sum of these toxins based on the available occurrence data are considered unlikely to be a health concern, while for pigs, poultry, dogs and horses the risk of adverse health effects is low. For cats the health risk from the exposure to T-2 and HT-2 toxins cannot be assessed.

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“…At the low dose immunstimulatory effects were observed and at the high dose immunosuppressive effects occurred (endpoint: haemagglutination inhibition titres against Newcastle disease virus). Further investigations of the same group showed that oral application of vitamin E increased antibody formation against Newcastle disease in animals, an effect which could not be suppressed by exposure to 2.35 mg/kg T-2 toxin in diet (Weber et al, 2008).…”

Section: In Vivomentioning

confidence: 98%

Report on toxicity data on trichothecene mycotoxins HT‐2 and T‐2 toxins

Schuhmacher-Wolz

Heine

Schneider

2010

EFSA Supporting Publications

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Effect of Vitamin E Supplementation on the Haemagglutination Inhibitor Titre Vaccinated against Newcastle Disease in T-2 Toxin Challenged Chickens

Cited by 9 publications

References 15 publications

Effects of Vitamins E and C Supplementation on the Immune Response of Broiler Chicks

Effects of Vitamins E and C Supplementation on the Immune Response of Broiler Chicks

Scientific Opinion on the risks for animal and public health related to the presence of T-2 and HT-2 toxin in food and feed

Report on toxicity data on trichothecene mycotoxins HT‐2 and T‐2 toxins

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