Effect of vitamin K on vascular health and physical function in older people with vascular disease–a randomised controlled trial

Fulton, Roberta; McMurdo, Marion E. T.; Hill, Alan R.; Abboud, Rami; Arnold, Graham; Struthers, Allan D.; Khan, Faisel; Vermeer, Cees; Knapen, Marjo H. J.; Drummen, Nadja E.A.; Witham, Miles D.

doi:10.1007/s12603-015-0619-4

Cited by 48 publications

(57 citation statements)

References 32 publications

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“…Specifically, the mean difference and SD in VC were calculated from median, IQR and sample size7 using a method described previously 18. SD of VS or VKDP was calculated from mean and 95% CI8 or mean and p value11 17 according to standard methods 19. Percentage effect sizes in VC, VS and ucVKDP were calculated to account for heterogeneity of type and scale of outcome measures.…”

Section: Methodsmentioning

confidence: 99%

Vitamin K status, supplementation and vascular disease: a systematic review and meta-analysis

Lees

Witham

et al. 2018

Heart

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ObjectivesVascular stiffness (VS) and vascular calcification (VC) are surrogate markers of vascular health associated with cardiovascular events. Vitamin K-dependent proteins (VKDP) are associated with VS and VC and require vitamin K for activity. We conducted a systematic review and meta-analysis of: (1) the effect of vitamin K supplementation on VS and VC and (2) association of inactive VKDP levels with incident cardiovascular disease and mortality.MethodsTwo authors searched MEDLINE and Embase databases and Cochrane and ISRCTN registries for studies of vitamin K clinical trials that measured effects on VC, VS or VKDP and longitudinal studies assessing effect of VKDP on incident CVD or mortality. Random effects meta-analyses were performed.ResultsThirteen controlled clinical trials (n=2162) and 14 longitudinal studies (n=10 726) met prespecified inclusion criteria. Vitamin K supplementation was associated with significant reduction in VC (−9.1% (95% CI −17.7 to −0.5); p=0.04) and VKDP (desphospho-uncarboxylated matrix Gla protein; −44.7% (95% CI −65.1 to −24.3), p<0.0001) and uncarboxylated osteocalcin; −12.0% (95% CI −16.7 to −7.2), p<0.0001) compared with control, with a non-significant improvement in VS. In longitudinal studies with median follow-up of 7.8 (IQR 4.9–11.3) years, VKDP levels were associated with a combined endpoint of CVD or mortality (HR 0.45 (95% CI 0.07 to 0.83), p=0.02).ConclusionsSupplementation with vitamin K significantly reduced VC, but not VS, compared with control. The conclusions drawn are limited by small numbers of studies with substantial heterogeneity. VKDP was associated with combined endpoint of CVD or mortality. Larger clinical trials of effect of vitamin K supplementation to improve VC, VS and long-term cardiovascular health are warranted.Trial registration numberCRD42017060344.

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Section: Methodsmentioning

confidence: 99%

Vitamin K status, supplementation and vascular disease: a systematic review and meta-analysis

Lees

Witham

et al. 2018

Heart

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“…One randomized controlled trial was further excluded as vitamin K, D, and calcium cosupplementation was compared against placebo 40. The remaining nine randomized, placebo-controlled trials29,30–37 met the inclusion criteria. However, two papers29,32 were duplicate reports.…”

Section: Resultsmentioning

confidence: 99%

“…However, two papers29,32 were duplicate reports. The paper reporting more complete data32 was included, leaving eight randomized controlled trials in the systematic review and meta-analysis30–37 (Figure 1). Of the eight trials, two30,35 enrolled the same group of participants, but reported different outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…Five studies30–32,35,36 evaluated vitamin K1 ranging from 500 to 1,000 µg/d. Two trials33,34 used vitamin K2 (MK-4) 1.5 and 45 mg/d, and one trial37 assessed vitamin K2 (MK-7) 100 µg/d. Subjects were older men or postmenopausal women who did not have diabetes at baseline 30,31,33–36.…”

Section: Resultsmentioning

confidence: 99%

“…Bone γ-carboxyglutamic acid protein can increase energy expenditure and adiponectin secretion from adipocytes 25–28. Clinical trials of vitamin K supplementation have reported conflicting results on its effect on insulin sensitivity 20,29,30–37. We therefore perform a systematic review and meta-analysis of randomized controlled trials to evaluate the effect of vitamin K supplementation on insulin sensitivity.…”

Section: Introductionmentioning

confidence: 99%

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Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis

Suksomboon

Poolsup

2017

DMSO

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ObjectiveTo perform a systematic review and meta-analysis of randomized, placebo-controlled trials to assess the effect of vitamin K supplementation on insulin sensitivity.Data sourcesMEDLINE, the Cochrane Library, CINAHL, Web of Science, Scopus, clinicaltrials.gov, and clinicaltrialresults.org were searched up to January 2017. Reference lists of related papers were also scanned.Study selectionRandomized controlled trials were selected if they compared vitamin K supplementation with placebo or no treatment and reported homeostasis model assessment of insulin resistance, fasting plasma glucose, fasting plasma insulin, C-reactive protein, adiponectin, leptin, or interleukin-6 levels.Data extractionData extraction and study quality assessment were performed independently by two investigators using a standardized data extraction form. Any inconsistencies were resolved by a third reviewer. Effect estimates were pooled using inverse-variance weighted method. Heterogeneity was assessed by the I2 and Q statistic.ResultsA total of eight trials involving 1,077 participants met the inclusion criteria. A wide variety of participants were enrolled, including older men, postmenopausal women, prediabetic premenopausal women, and participants with a history of diabetes, hypertension, or vascular disease. Vitamin K1 and vitamin K2 (MK-4 and MK-7 subtypes) were assessed. Supplementation period ranged from 4 weeks to 3 years. Vitamin K supplementation did not affect insulin sensitivity as measured by homeostasis model assessment of insulin resistance, fasting plasma glucose, fasting plasma insulin, C-reactive protein, adiponectin, leptin, and interleukin-6 levels.ConclusionOur analysis suggests no effect of vitamin K supplementation on insulin sensitivity.

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Antiatherogenic Effects of Vitamins, Mediterranean Diet and DASH Diet: An Overview for the Prevention of Cardiovascular Diseases

Kaur,

Dahiya,

Buttar

et al. 2024

Advances in Biochemistry in Health and Disease

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Effect of vitamin K on vascular health and physical function in older people with vascular disease–a randomised controlled trial

Abstract: Six months of vitamin K2 supplementation did not improve markers of vascular health or physical function in older patients with vascular disease.

Cited by 48 publications

References 32 publications

Vitamin K status, supplementation and vascular disease: a systematic review and meta-analysis

Vitamin K status, supplementation and vascular disease: a systematic review and meta-analysis

Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis

Antiatherogenic Effects of Vitamins, Mediterranean Diet and DASH Diet: An Overview for the Prevention of Cardiovascular Diseases

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