Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials

Yan-fu, Fang; Hu, Chuanlai; Tao, Xingyong; Wan, Yuhui; Tao, Fangbiao

doi:10.1007/s00774-011-0287-3

Cited by 92 publications

(63 citation statements)

References 44 publications

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“…Clinical meta-analyses have previously revealed that supplementation with vitamin D and vitamin K resulted in increased bone mineral density at the femoral neck and lumbar spine, respectively [48], which agrees with the significant increase in mineralization we observed using supplementation with vitamin D and K. Similar to our meta-analyses, the results of both of these studies must be treated with caution due to heterogeneity. However, we observed variable results of the effects of these vitamins on parameters indicative of bone formation depending on the type of cells used, which calls into question the use of particular cell lines and animal models to test drugs/supplements as a precursor to clinical studies.…”

Section: Figuresupporting

confidence: 91%

Effects of Vitamin D, K1, and K2 Supplementation on Bone Formation by Osteoblasts In Vitro: A Meta-analysis

Lancaster¹,

Harrison²

2017

J Biom Biostat

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Bone loss is a major health problem that many aging individuals will face and thus research focusing on enhancing bone formation is of great importance. Cell biology or in vitro studies are particularly useful in exploring the exact effects a vitamin, supplement or drug has on particular processes within a certain cell type. Although there have been many cell biology articles focusing on the effects of vitamin D, K 1 or K 2 addition on bone formation in vitro, there has yet to be a consensus amongst the literature. The purpose of this article is to determine the effects of vitamin D, K 1 and K 2 supplementation on osteoblast maturation parameters through meta-analysis of past cell biology literature. A Hedges d effect size was calculated for each experiment extracted from past literature and the experiments were grouped by experiment and cell type. Homogeneity was assessed by the Cochran's Q test, while the effect sizes' departure from zero was assessed by a 95% confidence interval and a non-directional test. Supplementation with vitamin D, K 1 and K 2 , along with the combination of vitamin K 2 + 1,25-dihydroxyvitamin D, increased bone mineralization, while not consistently affecting all of the other parameters associated with bone formation. Vitamin K 2 and D addition had variable effects on bone formation using different cell types, which calls into question the suitability of particular cell lines as models for clinical trials. Therefore, the conditions and parameters in which bone formation is studied in vitro must be considered carefully before running a vitamin supplementation or drug-testing experiment.

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Section: Figuresupporting

confidence: 91%

Effects of Vitamin D, K1, and K2 Supplementation on Bone Formation by Osteoblasts In Vitro: A Meta-analysis

Lancaster¹,

Harrison²

2017

J Biom Biostat

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“…Several recent meta-analyses and reviews of the effects of vitamin K supplementation show a positive effect on BMD and indices of bone strength, with reduced fracture incidence in mainly postmenopausal women; the majority of long-term trials supplemented MK4 to Japanese 8,69,70 . A subsequent study confirmed the beneficial effect of vitamin K1 supplementation on BMD in postmenopausal women, with doses of 80mcg/d phylloquinone proving effective 66 .…”

Section: Bonementioning

confidence: 99%

Cardiovascular Calcification and Bone: A Comparison of the Effects of Dietary and Serum Vitamin K and its Dependent Proteins

Nicoll¹,

Howard²,

Henein³

2015

ICFJ

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This review compares the effect of vitamin K on cardiovascular (CV) calcification and bone health and shows that, in principal, the γ-carboxylation of the vitamin K-dependent proteins matrix Gla protein (MGP) and its bone equivalent osteocalcin (OC), generally ensures that hydroxyapatite is kept out of the CV system and is deposited in bone. This is an important finding, since there is currently no reliable treatment for CV calcification.Vitamin K2 (menaquinone) may be more effective in the arteries, while vitamin K1 (phylloquinone) is more active in bone. Nevertheless, there remains considerable uncertainty over the precise scope of the functions of MGP and OC, and their carboxylated and under-carboxylated forms, as well as the newly discovered vitamin K-dependent proteins. Although a diet high in vegetables could deliver adequate phylloquinone, supplementation of menaquinone may be necessary for those at risk of CV calcification. Several animal studies and one human study have demonstrated that arterial calcification could be reduced with vitamin K supplementation and there are further trials in progress. Patients on warfarin are particularly prone to CV calcification but there has been concern that supplementation would either counter warfarin treatment or destabilise INR. In fact, studies suggest that low dose phylloquinone did not increase coagulation and may improve the stability of anticoagulant therapy. Furthermore, use of oral anticoagulants which do not affect vitamin K metabolism, such as ximelagatran, could be used when there is a need for vitamin K supplementation for artery or bone health.

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Section: What Do the Research Clinical Trials Say About Vitamin K Effmentioning

confidence: 99%

“…Each patient were either given vitamin K2 (in ten trials, eight of them were supplemented with MK-4 15-45 mg/ day and two with MK-7 0.2-3.6 mg.day) or vitamin K1 (in seven trials 0.2-10 mg/day) supplements (6). After 6 to 36 months of vitamin K supplementation, no significant increase of BMDs was observed in patients' femoral necks, but the average BMDs of the patient's' lumbar spines increased by 1.3% (6) . Specifically, patients given vitamin K2 treatments experienced a significant 1.8% increase in their average lumbar spine BMDs, while patients treated with vitamin K1 supplements did not experience the same significant increases in their average BMDs (6) .…”

Section: What Do the Research Clinical Trials Say About Vitamin K Effmentioning

confidence: 99%

The Connection Between Vitamin K and Bone Health

2015

JSST

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Vitamin K is essential to the body because it is known to help blood coagulate and activate osteocalcin, a protein involved in maintaining healthy bones. In this review, one study observing the impact of vitamin K supplementation on patients' bone mineral densities and three studies focusing on the effects of vitamin K supplementation on the incidence of bone fractures are discussed to determine whether the vitamin may be important for maintaining bone health. While some promising results, such as an increase in bone mineral density of subjects after vitamin K supplementation arose, the conclusions reached by the four studies were not statistically significant enough to justify the importance of vitamin K in maintaining bone health. Well-controlled studies that are unbiased, statistically powerful, and focused on vitamin K's effects on bone density are required in the future to provide further insight on whether vitamin K supplementation is a viable method of improving bone health.La vitamine K est essentielle pour le corps, car il est connu pour assister dans la coagulation du sang ainsi qu'activer l'ostéocalcine, une protéine impliquée dans le maintien de la santé des os. Ici, une étude dirigé vers les observations de l'impact de la consommation de suppléments de la vitamine K sur la densité minérale osseuse de patients, puis trois autres études portant sur les effets de la consommation de suppléments de la vitamine K sur l'incidence des fractures osseuses sont examinées afin de déterminer si la vitamine soit une facteur important dans le maintien de la santé des os. Tandis que des résultats sont révélés prometteurs, comme ceux montrant une augmentation de la densité minérale osseuse des sujets après la consommation des suppléments de la vitamine K, l'ensemble de conclusions tirées des quatre études ne présente pas suffisamment de données qui pourraient suggérer une corrélation entre la consommation des suppléments de la vitamine K et la santé des os. Des études supplémentaires portant sur les effets de la vitamine K sur la densité osseuse, mené dans des conditions contrôlés, bien conçus, impartiales, qui produiront des résultats persuasifs, sont nécessaires à être effectuer à l'avenir afin de donner un meilleur aperçu de l'effet de la supplémentation en vitamine K comme une méthode viable dans l'entretien de la santé des os.

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Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials

Cited by 92 publications

References 44 publications

Effects of Vitamin D, K1, and K2 Supplementation on Bone Formation by Osteoblasts In Vitro: A Meta-analysis

Effects of Vitamin D, K1, and K2 Supplementation on Bone Formation by Osteoblasts In Vitro: A Meta-analysis

Cardiovascular Calcification and Bone: A Comparison of the Effects of Dietary and Serum Vitamin K and its Dependent Proteins

The Connection Between Vitamin K and Bone Health

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