Effect of vitamin <scp>C</scp> on the growth of experimentally induced endometriotic cysts

Durak, Yıldırım; Kökçü, Arif; Kefeli, Mehmet; Bildircin, Devran; Celik, Handan; Alper, Tayfun

doi:10.1111/jog.12050

Cited by 26 publications

(21 citation statements)

References 20 publications

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“…Santanam et al attributed the effects of vitamin supplementation to its antioxidative and anti-inflammatory properties, although they did not describe any clear physiological mechanism underlying this effect [ 130 ]. Some insight come from Durak et al who experimentally induced endometriotic cysts in a rat model [ 131 ] subsequently treated with differing doses of vitamin C (0.5 mg, 1.25 mg, and 2.5 mg) to determine whether vitamin C supplementation altered lesion volume and weights. At the end of treatment, cystic lesions in the group treated with 2.5 mg vitamin C were significantly reduced in weight and volume [ 131 ], suggesting that antioxidants, such as vitamin C, are able to reduce endometriosis symptoms by reducing lesion size.…”

Section: Resultsmentioning

confidence: 99%

The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner

Vitale

Capriglione

Peterlunger

et al. 2018

Oxidative Medicine and Cellular Longevity

103

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Endometriosis is a condition characterized by the presence of endometrial tissue outside the uterine cavity, leading to a chronic inflammatory reaction. It is one of the most widespread gynecological diseases with a 10–15% prevalence in the general female population, rising up to 30–45% in patients with infertility. Although it was first described in 1860, its etiology and pathogenesis are still unclear. It is now accepted that inflammation plays a central role in the development and progression of endometriosis. In particular, it is marked by an inflammatory process associated with the overproduction of an array of inflammatory mediators such as prostaglandins, metalloproteinases, cytokines, and chemokines. In addition, the growth and adhesion of endometrial cells in the peritoneal cavity due to reactive oxygen species (ROS) and free radicals lead to disease onset, its ensuing symptoms—among which pain and infertility. The aim of our review is to evaluate the role of oxidative stress and ROS in the pathogenesis of endometriosis and the efficacy of antioxidant therapy in the treatment and mitigation of its symptoms.

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Section: Resultsmentioning

confidence: 99%

The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner

Vitale

Capriglione

Peterlunger

et al. 2018

Oxidative Medicine and Cellular Longevity

103

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“…Previous studies that evaluated histologic changes in endometriosis used GT and ST scoring systems [25][26][27]. Among previous rat endometriosis models that used these scoring systems, imiquimod, interferon-α-2b and dexketoprofen reduced both GT and ST scores significantly, but anastrozole and raloxifene only reduced GT scores [25,27,28].…”

Section: Discussionmentioning

confidence: 99%

The Non-Ergot Derived Dopamine Agonist Quinagolide as an Anti-Endometriotic Agent

Akyol¹,

Kavak²,

Akyol

et al. 2016

Gynecol Obstet Invest

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Aim: The study aimed to investigate the efficacy of a dopamine agonist, quinagolide, on experimentally induced endometriosis in a rat model. Methods: Twenty female Wistar rats were used in this experiment. Endometriosis was surgically induced by transplantation of autologous endometrial tissue. A second laparotomy was performed 4 weeks after the first one to assess the pre-treatment implant volumes, and peritoneal lavage with saline solution was performed to assess the peritoneal cytokine levels. Rats were randomized to treatment with quinagolide or saline. At the end of the treatment period, a third laparotomy was performed to compare pre- and post-treatment implant volumes and cytokine levels within the groups. Implants were excised to compare glandular tissue (GT) and stromal tissue (ST) scores between the groups. Results: In the quinagolide group, post-treatment volume was statistically significantly reduced compared with pre-treatment volume (p = 0.01). There were significant decreases in interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) levels in peritoneal fluid samples in quinagolide-treated rats when compared to pre-treatment levels (p = 0.03 and p < 0.01). Histopathologically, both GT and ST scores were significantly lower in the quinagolide group compared to the control group (p = 0.01 and p = 0.02). Conclusions: Quinagolide caused a significant regression in endometriotic implants and it also significantly reduced the levels of IL-6 and VEGF in peritoneal fluid.

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“…In an animal study, Durak et al [93] randomly assigned experimentally induced endometriotic cysts in rats to different dosages of vitamin C supplementation compared to a placebo group. The endometriotic cysts volume and weight as well as the natural killer cell content of the cysts were compared.…”

Section: Vitamins C and Ementioning

confidence: 99%

“…Minimizing oxidative stress Durak Y et al [93] Animal study Reduction of endometriotic cyst volume, weight, growth and natural killer cell content Antioxidant and immune stimulator, stimulation of leukocyte functions as phagocytosis, enhanced NK function Mier-Cabrera J et al [95] Human clinical study Decrease in OS markers: MDA, lipid hydroperoxides Neutralizing ROS as OH, alkolyl, peroxyl, and superoxide anions, hydroperoxyl radicals, and RNS such as NO and peroxinitrite, Foyouzi N et al [135] In vitro Inhibition of thymidine incorporation and proliferation of endometrial stromal cells…”

Section: Reduction Of Oxidatively Modified Lipoproteinsmentioning

confidence: 99%

Targeting oxidative stress to treat endometriosis

Harlev

Gupta

Agarwal

2015

Expert Opinion on Therapeutic Targets

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Effect of vitamin C on the growth of experimentally induced endometriotic cysts

Abstract: The dose-dependent vitamin C supplementation significantly reduced the volumes and weights of the endometriotic cysts.

Cited by 26 publications

References 20 publications

The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner

The Role of Oxidative Stress and Membrane Transport Systems during Endometriosis: A Fresh Look at a Busy Corner

The Non-Ergot Derived Dopamine Agonist Quinagolide as an Anti-Endometriotic Agent

Targeting oxidative stress to treat endometriosis

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