Effect of vitexin on alleviating liver inflammation in a dextran sulfate sodium (DSS)-induced colitis model

Duan, Shuni; Du, Xiongming; Chen, Shuxian; Liang, Jian; Huang, Song; Hou, Shaozhen; Gao, Jie; Ding, Ping

doi:10.1016/j.biopha.2019.109683

Cited by 48 publications

(28 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well known that the liver is a major handler of lipid metabolism (53), and the disturbances in lipid metabolism are one of the signals of liver injury (54). Not surprisingly, hepatocyte necrosis and inflammatory cell infiltration were observed in the liver tissue of the DSS group in this study, which was also reported by Duan et al (34).…”

Section: Discussionsupporting

confidence: 88%

“…IBD is considered to be one of the factors affecting liver homeostasis, patients with IBD often present with symptoms of liver injury (8,32). In this study, increased serum levels of cytokines and lipid metabolism-related indicators in the DSS group indicated impaired liver function (33,34). Histological analysis of the liver showed swollen hepatocytes, larger nuclei, narrower hepatic sinusoids, and infiltration of inflammatory cells between the hepatic sinusoids and lobules in the DSS group (Figure 2A).…”

Section: Dss Treatment Induced Liver Injury and Altered Gene Expression In Micementioning

confidence: 66%

See 1 more Smart Citation

Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice

et al. 2022

View full text Add to dashboard Cite

Liver injury is a common complication of inflammatory bowel disease (IBD). However, the mechanisms of liver injury development are not clear in IBD patients. Gut microbiota is thought to be engaged in IBD pathogenesis. Here, by an integrated analysis of host transcriptome and colonic microbiome, we have attempted to reveal the mechanism of liver injury in colitis mice. In this study, dextran sulfate sodium (DSS) -induced mice colitis model was constructed. Liver transcriptome showed significant up- and down-regulation of pathways linked to immune response and lipid metabolism, respectively. Whilst the colon transcriptome exhibited dramatic alterations in immune response and pathways associated with cell growth and death. The microbiota of DSS-treated mice underwent strong transitions. Correlation analyses identified genes associated with liver and colon injury, whose expression was associated with the abundance of liver and gut health-related bacteria. Collectively, the results indicate that the liver injury in colitis mice may be related to the intestinal dysbiosis and host-microbiota interactions. These findings may provide new insights for identifying potential targets for the treatment of IBD and its induced liver injury.

show abstract

Section: Discussionsupporting

confidence: 88%

Section: Dss Treatment Induced Liver Injury and Altered Gene Expression In Micementioning

confidence: 66%

Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Passiflora subpeltata , Citrus aurantium , Ipomoea asarifolia ) which contain phenolic compounds derivatives (gallic acid, apigenin, catechin, luteolin, quercetin, alpinetin, rutin) showed that their extracts have significant intestinal anti-inflammatory effects due to their ability to suppress levels of inflammatory and oxidative mediators ( da Silva et al, 2018 ; He et al, 2019 ; Shanmugam et al, 2020 ). Park et al (2012) ; Sotnikova et al (2013) ; Mascaraque et al (2015) ; Carrera-Quintanar et al (2018) ; Duan et al (2020) and Vezza et al (2016) report that flavonoids (among them quercetin and kaempferol) have shown remarkable effects in the attenuation of intestinal inflammation in pharmacological studies (e.g. DNBS- and DSS-model) in animals (rodents) and in clinical studies.…”

Section: Discussionmentioning

confidence: 99%

“…According to researchers, flavonoids suppressed the activation of TLR-4/NF-κB p65 signaling pathway, leading to a decrease in gene expression of TNF-α, IL-1B, and IL-6, COX-2, TFF-3, and iNOS proteins in the intestinal mucosa in colitis model ( Park et al, 2012 ; Sotnikova et al, 2013 ; Vezza et al, 2016 ; Duan et al, 2020 ). Previous reports also demonstrated the potential effects of treatment with B. pinnatum leaf extracts as antioxidant and immunoregulator, promoting down-regulation inflammatory markers (IL-6, IL-1β, TNF-α, iNOS, NF-κB p65, and COX-2) in animal models for allergic airway disease ( Cruz et al, 2012 ), acute, and chronic skin inflammation ( Chibli et al, 2014 ), local inflammation induced by Bothrops jararaca snake venom ( Fernandes et al, 2016 ) and showing a protective effect on gastric lesion ( Sobreira et al, 2017 ; de Araújo et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Chemopreventive Effects of Bryophyllum pinnatum (Lamarck) Leaf Extract in Experimental Colitis Models in Rodents

et al. 2020

View full text Add to dashboard Cite

pro-inflammatory and oxidative mediators, chemokines, and cell adhesion molecules. This immunomodulatory property was proposed that one of the possible action mechanisms of extract. An improvement in intestinal damage was also associated with a reduction in oxidative stress and infiltration of leukocytes, as evidenced by the reduction in malonaldialdehyde and myeloperoxidase activity and increase in total glutathione in the colonic tissue. Moreover, the extract improved the cytoarchitecture of the colonic tissue and the integrity of the intestinal epithelial barrier by restoring the expression of the proteins associated with mucosa protection. In view of the beneficial effects showed by the B. pinnatum leaf extract in preclinical rodent models of colitis there is the potential to conduct some future clinical studies to ensure safe and effective development of a phytotherapeutic treatment for human inflammatory bowel diseases.

show abstract

“…Although highly curable in early stages, advanced stage PCa is associated with a high risk of metastases and resulting dramatic reductions in 5-year survival rates 2 . Smoking, diet, and increased body mass index (BMI) are all modifiable risk factors for advanced stage PCa 3 . Treatment typically involves androgen deprivation therapy (ADT) to pharmaceutically inhibit the production of androgens, such as testosterone, that are important for PCa development and growth.…”

Section: Introductionmentioning

confidence: 99%

Dietary tomato inhibits angiogenesis in TRAMP prostate cancer but is not protective with a Western-style diet in this pilot study

Applegate

Lowerison

Hambley

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Prostate cancer (PCa) remains the second most diagnosed cancer worldwide. Higher body weight is associated with chronic inflammation, increased angiogenesis, and treatment-resistant tumor phenotypes. Dietary tomato reduces PCa risk, which may be due to tomato inhibition of angiogenesis and disruption of androgen signaling. This pilot study investigated the interplay between tomato powder (TP), incorporated into control (CON) and obesogenic (OB) diets, and PCa tumor growth and blood perfusion over time in a transgenic model of PCa (TRAMP). Ultrasound microvessel imaging (UMI) results showed good agreement with gold-standard immunohistochemistry quantification of endothelial cell density, indicating that this technique can be applied to non-invasively monitor tumor blood perfusion in vivo. Greater body weight was positively associated with tumor growth. We also found that TP significantly inhibited prostate tumor angiogenesis but that this inhibition differentially affected measured outcomes depending on CON or OB diets. TP led to reduced tumor growth, intratumoral inflammation, and intratumoral androgen-regulated gene expression (srd5a1, srd5a2) when incorporated with the CON diet but greater tumor growth and intratumoral gene expression when incorporated with the OB diet. Results from this study show that protective benefits from dietary tomato are lost, or may become deleterious, when combined with a Western-style diet.

show abstract

Effect of vitexin on alleviating liver inflammation in a dextran sulfate sodium (DSS)-induced colitis model

Cited by 48 publications

References 36 publications

Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice

Multi-Omics Analysis of the Gut-Liver Axis Reveals the Mechanism of Liver Injury in Colitis Mice

Anti-Inflammatory and Chemopreventive Effects of Bryophyllum pinnatum (Lamarck) Leaf Extract in Experimental Colitis Models in Rodents

Dietary tomato inhibits angiogenesis in TRAMP prostate cancer but is not protective with a Western-style diet in this pilot study

Contact Info

Product

Resources

About