Effect of Walnut Meal Peptides on Hyperlipidemia and Hepatic Lipid Metabolism in Rats Fed a High-Fat Diet

Abstract

As a natural active substance that can effectively improve blood lipid balance in the body, hypolipidemic active peptides have attracted the attention of scholars. In this study, the effect of walnut meal peptides (WMP) on lipid metabolism was investigated in rats fed a high-fat diet (HFD). The experimental results show that feeding walnut meal peptides counteracted the high-fat diet-induced increase in body, liver and epididymal fat weight, and reduce the serum concentrations of total cholesterol, triglycerides, and LDL-cholesterol and hepatic cholesterol and triglyceride content. Walnut meal peptides also resulted in increased HDL-cholesterol while reducing the atherosclerosis index (AI). Additionally, the stained pathological sections of the liver showed that the walnut meal peptides reduced hepatic steatosis and damage caused by HFD. Furthermore, walnut meal peptide supplementation was associated with normalization of elevated apolipoprotein (Apo)-B and reduced Apo-A1 induced by the high-fat diet and with favorable changes in the expression of genes related to lipid metabolism (LCAT, CYP7A1, HMGR, FAS). The results indicate that walnut meal peptides can effectively prevent the harmful effects of a high-fat diet on body weight, lipid metabolism and liver fat content in rats, and provide, and provide a reference for the further development of walnut meal functional foods.

Ginsenoside Rb1 ameliorates Glycemic Disorder in Mice With High Fat Diet-Induced Obesity via Regulating Gut Microbiota and Amino Acid Metabolism

“…In current study, HFD induced the decrease of cecum weight, which is consistent with previous researches ( Chen et al, 2019 ; Berger et al, 2021 ). The byproducts of lipid metabolism in a HFD would injure the mucosa of the large intestine and decrease the mucosal thickness of the cecum ( Yang et al, 2021 ). A recent report has shown that infiltration of inflammatory cells, ulceration, and epithelial damage were also detected in the cecum and colon of mice fed with HFD ( Liu et al, 2021 ).…”

The Ameliorative Effect and Mechanisms of Ruditapes philippinarum Bioactive Peptides on Obesity and Hyperlipidemia Induced by a High-Fat Diet in Mice

“…The mice fed with HFD were randomly divided into four groups (n = 8 each): Model (Mod) group, gavaged with normal saline; Low dose RBPs (LRBP) group, gavaged with 200 mg/kg RBPs; High dose RBPs (HRBP) group, gavaged with 600 mg/kg RBPs; Simvastatin (Sim) group, gavaged with 2.6 mg/kg simvastatin. The mice received corresponding gavage every day at a fixed time for 6 weeks and the treatment dose was referenced to previous publications [ 20 , 26 ].…”

“…At present, researchers tend to explore natural substitutes, such as food-derived bioactive peptides to replace synthetic drugs for improving and preventing diseases, including obesity and hyperlipidemia [ 18 ]. Anti-obesity and hypolipidemic peptides have been isolated from Skate skin [ 19 ], walnut meal [ 20 ], silk and silk pupa [ 21 ], hazelnut [ 22 ], and bovine milk [ 23 , 24 ].…”

An updated review on food‐derived bioactive peptides: Focus on the regulatory requirements, safety, and bioavailability

“…Hyperlipidemia is a lipid MetS in the body and a risk factor in atherosclerosis and consequent cardiovascular illnesses. Yang et al (2021) scrutinized the effect on hyperlipidemia and lipid metabolism of walnut meal peptides (WMP) in rats given HFD. Findings from experiments revealed that administration of WMPs prevented the HFD triggered upsurge in the weight of the body, liver, and epididymal fat, plummeted the total serum concentration of cholesterol, TGs content, LDLcholesterol, and hepatic cholesterol.…”