Effect of Walnut Seed Skin Against Main Organ Damage Caused by Hyperlipidemia

Palabıyık, Esra; Aşkın, Seda; Aşkın, Hakan

doi:10.31590/ejosat.1084073

Cited by 3 publications

(4 citation statements)

References 19 publications

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“…In a previous in vivo study on Wistar rats, it was reported that walnut septum extracts did not show subacute or acute toxic effects at doses of 1000 mg/kg (body weight) (Ravanbakhsh et al, 2016). E-WSC, which is the active ingredient of our study and has a rich content, greatly relieves kidney damage due to hyperlipidemia (Palabiyik et al, 2022) and the total flavonoids extracted from the leaves of Actinidia kolomikta improve hyperlipidemia through this mechanism (Yu et al, 2017) supports this thesis.…”

Section: Lipid Peroxidation and Antioxidant System Modulation Of E-ws...supporting

confidence: 68%

“…In other words, by inhibiting lipoprotein lipase (LPL) activity, it causes the accumulation of very low-density lipoprotein (VLDL) and TGs and reduces HDL-C production (Zarzecki et al, 2014). Studies have shown that a single intraperitoneal administration of Triton WR-1339 to adult rats produces hyperlipidemia within 24 hours (Palabiyik et al, 2022;Sheikha et al, 2018). Statins are a group of synthetic drugs used as a primary step in regulating lipid metabolism and reducing LDL-C levels (Nelson, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Walnut Seed Coat (Juglans regia L.), a Plant Effective in Human Health: Antioxidant Activity and in Rats Nephroprotective Effect

Palabıyık,

Uğuz,

Aşkın

et al. 2024

Research in Agricultural Sciences

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In the study, the seed coat (WSC) of Posof (Ardahan/Türkiye) walnuts was extracted to determine their phytochemical components and antioxidant capacities. The effects of bioactive components in the ethanol extract of WSC (E-WSC) on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitors were investigated. Additionally, antioxidant enzyme activity parameters were measured in the kidney tissues of Triton WR-1339-induced hyperlipidemic rats. Bioactive compounds in WSC were identified by GC-MS system. The antioxidant properties of WSC were measured using Fe+3, Cu+2 and Fe+3-2,4,6-tripyridyl-s-triazine (TPTZ) reducing agent, 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'- azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging activities. In this analysis, using 30 male Wistar rats (300 ± 30 g) randomly divided into five groups were treated as follows; K1: Healthy control group, K2: E-WSC (150 mg) o.d., K3: E-WSC (300 mg) o.d., K4: Hyperlipidemic group i.p., K5: Hyperlipidemic group i.p. + E-WSC (300 mg) o.d. Superoxide dismutase (SOD), catalase (CAT) and malondialdehyde (MDA) analyzes were performed in kidney tissues. Based on these results, it was clearly determined that E-WSC has significant antioxidant activity due to its bioactive components, has an inhibitory effect on AChE and BChE enzymes, and has a protective effect against oxidative stress by improving hyperlipidemia-related kidney damage.

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Section: Lipid Peroxidation and Antioxidant System Modulation Of E-ws...supporting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Walnut Seed Coat (Juglans regia L.), a Plant Effective in Human Health: Antioxidant Activity and in Rats Nephroprotective Effect

Palabıyık,

Uğuz,

Aşkın

et al. 2024

Research in Agricultural Sciences

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“…Other studies have supported this by demonstrating that E‐WFD improves histopathological damage to the kidney induced by hyperlipidemia and exerts protective effects on kidney tissue. [ 53 ] Considering that hyperlipidemia is the inducing factor, leading to lipotoxicity‐induced renal apoptosis and dysfunction, it is evident that such conditions may also affect related organs. [ 54 ] The data obtained from the use of E‐WFD in our study align with and support this perspective.…”

Section: Discussionmentioning

confidence: 99%

Walnut fruit diaphragm ethanol extract ameliorates damage due to Triton WR‐1339‐induced hyperlipidemia in rats

Palabiyik,

Sulumer,

Uguz

et al. 2023

Euro J Lipid Sci & Tech

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The walnut fruit diaphragm (WFD) is an economically and ecologically important by‐product of the Juglandaceae family. Components in the ethanolic extract of WFD (E‐WFD) were identified by gas chromatography‐mass spectroscopy (GC‐MS). In our study, the lipid‐lowering effect, antioxidant potential, and anti‐inflammatory properties of E‐WFD in the blood, heart, and liver tissues of rats (♂, Wistar) with hyperlipidemia caused by Triton WR‐1339 were determined using biochemical, histopathological, and molecular techniques. Experimental animals for analysis are as follows: K1: healthy control group, K2: E‐WFD (150 mg, o.d.), K3: E‐WFD (300 mg, o.d.), K4: HL (hyperlipidemic group) (400 mg kg–1 Triton WR‐1339, i.p.), K5: HL + E‐WFD (300 mg) grouped as (n = 6). After the application, anti‐hyperlipidemic analysis (TC, TG, LDL‐C, HDL‐C, ALT, and AST), oxidative stress (MDA, SOD, and CAT) parameters measurement, histopathological examinations, and inflammatory biomarker genes (Tnf‐α, Il‐6, Il‐1β, Mmp‐2, Mmp‐9, Lxr‐α and Srebp‐1c) expression stability were determined by q‐RT PCR. With the E‐WFD application, there was a decrease in TC and TG levels and an increase in HDL‐C. Oxidative stress decreased by changing MDA, SOD, and CAT levels. Histopathological deterioration in the tissues changed positively. In addition, E‐WFD showed significant inhibitory properties on Tnf‐α, Il‐6, Il‐1β, Mmp‐2, Mmp‐9, Lxr‐α, and Srebp‐1c genes.Practical applications: It is known that hyperlipidemia causes a wide range of diseases. In this study, the effect of walnut fruit diaphragm (WFD) ethanol extract was compared against the effect of Triton WR‐1339‐induced hyperlipidemia on rats. With the use of WFD, the damages caused by hyperlipidemia were significantly ameliorated. Accordingly, it is expected to contribute to the pharmacology, food and cosmetic industries as a very valuable alternative product.]

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“…In order to keep these negative situations under control, it is necessary to reduce the lipid level. Although a range of synthetic drugs are available having anti-hyperlipidaemic effects, they may produce unwanted as well as therapeutic effects [2,3]. For this reason, herbal products gain more attention as alternative treatment due to the absence of undesirable side-effects, and their economic and easy accessibility.…”

Section: Introductionmentioning

confidence: 99%

Preventive effects of <i>Trigonella foenum-graecum</i> and <i>Allium sativum</i> against Triton induced hyperlipidaemia in rabbits

IMRAN,

Sohail,

Khan

et al. 2023

J Pre Clin Clin Res.

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Introduction and Objective. Hyperlipidaemia is the greatest risk factor of coronary heart disease and currently available hypolipidemic drugs have been associated with number of side effects. Several studies have demonstrated the role of Trigonella foenum-graecum and Allium sativum in improvement of lipid profile and suggest their use as alternative and natural source for prevention / long term management of hyperlipidaemia. Materials and method. The study investigates synergetic antihyperlipidemic effects of polyherbal formulation containing T. foenum-graecum seeds and A. sativum buds (ratio 7:3) in Triton-induced acute hyperlipidaemia in rabbits, and compared with standard Atorvastatin. All animals were fed their respective samples orally without any base material for the period of one week. On day 7, blood samples were collected directly from the marginal ear vein of all rabbits before dosing. Immediately after the last dose, Triton WR-1339 (200 mg/kg i.p.) (Tyloxapol) (Sigma-aldrich Corp., USA) in normal saline was injected into all groups. After 24 h of Triton injection, blood samples were again collected from marginal ear vein of all animals for analysis of total cholesterol (TC), triglycerides (TG), HDL cholesterol and LDL cholesterol. Results. Seven days pretreatment of polyherbal formulation clearly demonstrated significant anti-hyperlipidaemic effects by showing TC 40.4 (p <0.05*), TG 36.6 (p <0.01**), HDL 25.8 and LDL 10.6 mg/dl (p <0.01**) in comparison with control group that exhibited TC 94.6, TG 812.6, HDL 20 and LDL 91.6 mg/dl lipid values. The standard group also exhibited potent results by showing TC 46, TG 198.6 (p <0.01**), HDL 37.6 (p <0.05*) and LDL 31.6 mg/dl (p <0.05*) values. Conclusion. The results obtained suggest that the regular use of a moderate amount of T. foenum-graecum and A. sativum in the diet may offer protection against hyperlipidaemia.

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Effect of Walnut Seed Skin Against Main Organ Damage Caused by Hyperlipidemia

Cited by 3 publications

References 19 publications

Walnut Seed Coat (Juglans regia L.), a Plant Effective in Human Health: Antioxidant Activity and in Rats Nephroprotective Effect

Walnut Seed Coat (Juglans regia L.), a Plant Effective in Human Health: Antioxidant Activity and in Rats Nephroprotective Effect

Walnut fruit diaphragm ethanol extract ameliorates damage due to Triton WR‐1339‐induced hyperlipidemia in rats

Preventive effects of <i>Trigonella foenum-graecum</i> and <i>Allium sativum</i> against Triton induced hyperlipidaemia in rabbits

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