Effect of Warm Compress Therapy From Hard-Boiled Eggs on Corneal Shape

Lam, Andrew K. C.; Lam, Chin-Hang

doi:10.1097/01.ico.0000248380.86401.4d

Cited by 16 publications

(15 citation statements)

References 13 publications

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“…Ciolino and Belin 29 and Ciolino and associates 44 recently reported that when using the Pentacam there is no posterior corneal protrusion in patients who have received refractive surgery within the first month 29 and after one year 44 . Placido disc‐based corneal topographers are commonly used for corneal research 13,69–77 because of their superior performances in measuring corneal curvature and corneal eccentricity 78–80 . The corneal parameters are derived from the reflection of the Placido discs at the tear film, which cannot provide any information about the posterior corneal surface.…”

Section: Discussionmentioning

confidence: 99%

Reliability and repeatability of the Pentacam on corneal curvatures

Chen

Lam

2009

Clinical and Experimental Optometry

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Background:The purpose of this study was to assess the intra-observer reliability and inter-session repeatability of the Pentacam system (Oculus, Inc.) on the simulated keratometry readings (Sim K) and peripheral corneal curvatures (PCC) at both the anterior and posterior corneal surfaces. Methods: One eye was randomly selected from each of the 39 normal subjects from the School of Optometry at The Hong Kong Polytechnic University. In the first session, three readings were taken for reliability analysis. Measurements were repeated in a second session scheduled one to two weeks later for repeatability analysis. Two approaches were used, comparing the first reading between the two sessions and comparing the average from three readings between the two sessions. Both the anterior and posterior Sim K and PCC were calculated from the tangential and axial maps. The inter-session repeatability was reported as the coefficient of repeatability (COR = Ϯ 1.96 ¥ standard deviation of differences). Relative repeatability (RR) was a percentage of the ratio of COR to the mean. Results: All parameters showed good intra-observer reliability (Cronbach's alpha Ն 0.925; intra-class correlation coefficient, ICC Ն 0.804), except for the posterior power vector J45 (= 0.896; ICC = 0.742) and tangential PCC at the superior region (= 0.891; ICC = 0.732). The inter-session repeatability on anterior Sim K (COR Յ Ϯ0.21 D; RR Յ 0.48 per cent) and posterior Sim K (COR Յ Ϯ0.09 D; RR Յ 1.39 per cent) was good. Axial PCC showed better repeatability than the tangential PCC. The COR from using the first approach for all the posterior PCC was within 0.23 D, while the COR reduced to within 0.16 D from using the second approach. Conclusions:The Pentacam showed good intra-observer reliability on Sim K and PCC measurements. Averaging three readings from one visit could improve repeatability between visits. Measurements of central and peripheral corneal curvature are useful for diagnosing and monitoring corneal conditions such as keratoconus [1][2][3][4][5] and for monitoring corneal shape following ocular surgery [6][7][8][9][10] or refractive procedures such as orthokeratology. [11][12][13][14][15] To monitor these corneal conditions longitudinally, the measurements should be repeatable. Most modern corneal topographers operate according to the Placido disc principle, where the tear film, shadows from brows and lashes, and the eyelids can interfere with the measurement [16][17][18][19] and no information on the posterior cornea can be 29,40,[42][43][44][45][46] calculating the keratometric index and intraocular lens power, 47-50 assessing intraocular lens implants 43,[51][52][53][54] and monitoring corneal changes during orthokeratology treatment. 33 The Pentacam's reliability and agreement with other ophthalmic instruments on central and peripheral corneal thickness 24,25,27,28,34,[55][56][57] and anterior chamber depth and angle 34,35,[58][59][60] have been rigorously examined. Previously, we investigated the inter-and intra-session repeatability of...

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Section: Discussionmentioning

confidence: 99%

Reliability and repeatability of the Pentacam on corneal curvatures

Chen

Lam

2009

Clinical and Experimental Optometry

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“…While it is widely prescribed, warm compress therapy for the treatment of MGD or evaporative dry eye suffers from many shortcomings 20–22. It has been shown that it is challenging to achieve and maintain therapeutically warm (>40°C) compresses in the clinic or at home 21.…”

Section: Introductionmentioning

confidence: 99%

TearCare® system extension study: evaluation of the safety, effectiveness, and durability through 12 months of a second TearCare® treatment on subjects with dry eye disease

Badawi¹

2019

OPTH

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PurposeEvaluation of the safety and effectiveness of a TearCare® retreatment in adult subjects with clinically significant dry eye disease (DED).Patients and methodsThis was an extension of an initial 6-month, prospective, single-center, randomized, parallel-group pilot study. In the initial study, subjects with DED were randomized to either a single TearCare® treatment or 4 weeks of daily warm compress therapy. The extension study involved retreatment of those subjects assigned to the TearCare® treatment group following the initial 6-month end point. At 6 months, subjects were evaluated for the clinical signs and symptoms of DED prior to retreatment in the extension study that would measure the safety, effectiveness, and durability of a TearCare® retreatment for another 6 months through a 12-month end point. The TearCare® retreatment procedure consisted of 12 minutes of thermal eyelid treatment immediately followed by manual meibomian gland clearance. The primary effectiveness end point was the change in tear break-up time (TBUT) from baseline to 1-month follow-up. Secondary end points included meibomian gland scores, corneal and conjunctival staining scores, and assessment of dry eye symptoms. Safety was evaluated through monitoring intraocular pressure, best-corrected visual acuity, and device-related adverse events.ResultsTwelve subjects participated in the 6-month extension study. At 1-month clinic visit following retreatment, a significant improvement from baseline in mean (± SD) TBUT of 12.4 (±3.3) seconds was observed (P<0.001). Significant improvements in the mean change from baseline in meibomian gland scores, corneal and conjunctival staining scores, and symptoms of DED were also observed following retreatment. The second treatment was well tolerated.ConclusionThe findings of the extension study through 12 months suggest that a second TearCare® treatment after 6 months provides additional improvement in the signs and symptoms of DED.

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“…WC therapy for the treatment of MGD is unfortunately plagued by many shortcomings. 21 , 22 As described above, other than a clinical study setting where an eye care provider is actively replacing WCs throughout the treatment, it is difficult to achieve and maintain a therapeutically warm (>40°C) compress. 21 Often, the WC may not be sufficiently warm, or it may cool too quickly.…”

Section: Introductionmentioning

confidence: 99%

A novel system, TearCare®, for the treatment of the signs and symptoms of dry eye disease

Badawi¹

2018

OPTH

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PurposeThe objective of this study was to evaluate the safety and effectiveness of the TearCare® System in adult patients with clinically significant dry eye disease (DED).Patients and methodsThis was a prospective, single-center, randomized, parallel-group, clinical trial. Subjects with DED were randomized to either a single TearCare treatment conducted at the clinic or 4 weeks of daily warm compress (WC) therapy. The TearCare procedure consisted of 12 minutes of thermal eyelid treatment immediately followed by manual expression of the meibomian glands. WC therapy consisted of once daily application of the compresses to the eyelids for 5 minutes. Subjects were followed until 6 months post-treatment. The primary effectiveness end point was defined as change from baseline to 4 weeks for tear breakup time (TBUT). Secondary effectiveness end points included meibomian gland assessment, corneal and conjunctival staining scores, and assessment of dry eye symptoms using validated questionnaires. Safety was evaluated by collecting device-related adverse events, intraocular pressure, and best spectacle-corrected Snellen Visual acuity.ResultsTwenty-four subjects were enrolled and all subjects completed 6 months follow-up. At the 1-month follow-up, TearCare subjects demonstrated an improvement from baseline in mean (±SD) TBUT of 11.7±2.6 seconds compared with an average worsening of −0.3±1.1 seconds for subjects in the WC group (p<0.0001). Significantly greater improvements in the change from baseline in meibomian gland scores, as well as corneal and conjunctival staining scores, were observed in the TearCare group. Subjects in the TearCare group also showed significantly greater improvement in dry eye symptoms as measured by the 3 questionnaires. Both treatments were well-tolerated.ConclusionThe findings of this pilot study suggest that the TearCare System is an effective treatment option for patients with DED, with the effects on the signs and symptoms of DED persisting for at least 6 months.

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Effect of Warm Compress Therapy From Hard-Boiled Eggs on Corneal Shape

Cited by 16 publications

References 13 publications

Reliability and repeatability of the Pentacam on corneal curvatures

Reliability and repeatability of the Pentacam on corneal curvatures

<p>TearCare<sup>®</sup> system extension study: evaluation of the safety, effectiveness, and durability through 12 months of a second TearCare<sup>®</sup> treatment on subjects with dry eye disease</p>

A novel system, TearCare<sup>®</sup>, for the treatment of the signs and symptoms of dry eye disease

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Effect of Warm Compress Therapy From Hard-Boiled Eggs on Corneal Shape

Cited by 16 publications

References 13 publications

Reliability and repeatability of the Pentacam on corneal curvatures

Reliability and repeatability of the Pentacam on corneal curvatures

<p>TearCare<sup>&reg;</sup> system extension study: evaluation of the safety, effectiveness, and durability through 12 months of a second TearCare<sup>&reg;</sup> treatment on subjects with dry eye disease</p>

A novel system, TearCare<sup>&reg;</sup>, for the treatment of the signs and symptoms of dry eye disease

Contact Info

Product

Resources

About

<p>TearCare<sup>®</sup> system extension study: evaluation of the safety, effectiveness, and durability through 12 months of a second TearCare<sup>®</sup> treatment on subjects with dry eye disease</p>

A novel system, TearCare<sup>®</sup>, for the treatment of the signs and symptoms of dry eye disease