Effect of warming Yang and removing blood stasis method on matrix metalloproteinases / tissue inhibitor metalloproteinases levels secreted by cultured endometrial cells from patients with endometriosis

Huang, Yanhui; Shen, Lin; Anhe, Cai; Jing, Xiao

doi:10.1016/s0254-6272(15)30141-2

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…The WYPBD was prepared according to the description in a previous study (Huang et al, 2015), which mainly includes the following ingredients: Radix angelicae sinensis (Danggui), Ramulus cinnamomi (Guizhi), Radix paeoniae alba (Baishao), Herba asari mandshurici (Xixin), Radix glycyrrhizae (honey fried Gancao), Medulla tetrapanaicis (Tongcao), Fructus jujubae (Dazao), Radix linderae aggregatae (Wuyao), Radix aconiti lateralis preparate (Fuzi), Rhizoma zingiberis (Ganjiang). The above ingredients were boiled and centrifuged at a speed of 2000 r/min for 10 min and 4000 r/min for 10 min, to obtain a crude drug at a concentration of 700 mg/ml in liquid.…”

Section: Preparation Of the Wypbd Reagentmentioning

confidence: 99%

Warming Yang Promoting Blood Circulation and Diuresis Alleviates Myocardial Damage by Inhibiting Collagen Fiber and Myocardial Fibrosis and Attenuating Mitochondria Signaling Pathway Mediated Apoptosis in Chronic Heart Failure Rats

Chen,

Tu,

et al. 2024

Tohoku J. Exp. Med.

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Section: Preparation Of the Wypbd Reagentmentioning

confidence: 99%

Warming Yang Promoting Blood Circulation and Diuresis Alleviates Myocardial Damage by Inhibiting Collagen Fiber and Myocardial Fibrosis and Attenuating Mitochondria Signaling Pathway Mediated Apoptosis in Chronic Heart Failure Rats

Chen,

Tu,

et al. 2024

Tohoku J. Exp. Med.

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Development of the Blood Stasis Questionnaire for Gynecological Diseases: An Analytical Cross-Sectional Study

Kang,

Jang,

et al. 2024

Complement Med Res

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Objectives: Blood stasis is the slowing or stagnation of blood and can cause metabolic, musculoskeletal, and gynecological diseases. This study developed the Blood Stasis Questionnaire for gynecological disease (BSQ-GD) by extracting clinical indicators related to gynecological diseases using the Blood Stasis Questionnaires I and II (BSQ-I and II, respectively) and analyzed the clinical data of a cross-sectional study. Patients and Methods: In total, 103 women aged between 25–65 years who met gynecological disease criteria were enrolled in this study. Blood stasis scores (BSS) were evaluated using the BSQ-II and categorized into BSS and non-BSS groups.To assess the reliability of BSQ-GD, the internal consistency coefficient was employed using Cronbach’s α. Furthermore, correlation analyses were conducted for the clinical symtoms related to gynecological diseases and and the discriminant validity was confirmed by comparing the two groups. The prediction accuracy was determined using logistic regression and the cut-off value of the BSQ-GD was established via the sensitivity and specificity cacluations. Results: The BSQ-GD showed satisfactory internal consistency (Cronbach’s α coefficient = 0.71) and validity, with significant differences in mean scores between blood stasis (22.30±3.34) and non-blood stasis (14.93±3.49) groups. The cut-off value of the BSQ-GD score was 19 points when the Youden index (73.45) and the concordance probability (0.75) were at their maximum. The area under the receiver operating characteristic curve was approximately 96%, and the sensitivity and specificity of the diagnostic accuracy according to the cut-off value are 80.95% and 92.50%, respectively. Conclusion: The BSQ-GD can be an appropriate instrument to estimate blood stasis in patients with gynecological diseases; its diagnostic sensitivity according to the cut-off value is high.

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Anti-endometriosis Mechanism of Jiawei Foshou San Based on Network Pharmacology

et al. 2018

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Jiawei Foshou San (JFS) is the new formula originated from classic Foshou San formula, composed with ligustrazine, ferulic acid, and tetrahydropalmatine. Previously JFS inhibited the growth of endometriosis (EMS) with unclear mechanism, especially in metastasis, invasion, and epithelial–mesenchymal transition. In this study, network pharmacology was performed to explore potential mechanism of JFS on EMS. Through compound–compound target and compound target–EMS target networks, key targets were analyzed for pathway enrichment. MMP–TIMP were uncovered as one cluster of the core targets. Furthermore, autologous transplantation of EMS rat’s model were used to evaluate in vivo effect of JFS on invasion, metastasis and epithelial–mesenchymal transition. JFS significantly suppressed the growth, and reduced the volume of ectopic endometrium, with modification of pathologic structure. In-depth study, invasion and metastasis were restrained after treating with JFS through decreasing MMP-2 and MMP-9, increasing TIMP-1. Meanwhile, JFS promoted E-cadherin, and attenuated N-cadherin, Vimentin, Snail, Slug, ZEB1, ZEB2, Twist. In brief, anti-EMS effect of JFS might be related to the regulation of epithelial–mesenchymal transformation, thereby inhibition of invasion and metastasis. These findings reveal the potential mechanism of JFS on EMS and the benefit for further evaluation.

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Effect of warming Yang and removing blood stasis method on matrix metalloproteinases / tissue inhibitor metalloproteinases levels secreted by cultured endometrial cells from patients with endometriosis

Cited by 3 publications

References 21 publications

Warming Yang Promoting Blood Circulation and Diuresis Alleviates Myocardial Damage by Inhibiting Collagen Fiber and Myocardial Fibrosis and Attenuating Mitochondria Signaling Pathway Mediated Apoptosis in Chronic Heart Failure Rats

Warming Yang Promoting Blood Circulation and Diuresis Alleviates Myocardial Damage by Inhibiting Collagen Fiber and Myocardial Fibrosis and Attenuating Mitochondria Signaling Pathway Mediated Apoptosis in Chronic Heart Failure Rats

Development of the Blood Stasis Questionnaire for Gynecological Diseases: An Analytical Cross-Sectional Study

Anti-endometriosis Mechanism of Jiawei Foshou San Based on Network Pharmacology

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