Effect of Water Deprivation on Aspirin Disposition Kinetics

Bakar, Shamsul K.; Niazi, Sarfaraz K.

doi:10.1002/jps.2600720916

Cited by 36 publications

(27 citation statements)

References 33 publications

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“…It was reported that there was no significant change in the volume of distribution of antipyrine and aspirin following 36 hr of water deprivation in rats (1,3). On the other hand, biological half-lives of antipyrine and aspirin were prolonged, and their total body clearance was decreased.…”

Section: Discussionmentioning

confidence: 96%

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Influence of Short-Term Water Deprivation on Kinetics of Trimethadione and Its Metabolite in Rats

Tanaka

Kurata

Kuroiwa

et al. 1986

Japanese Journal of Pharmacology

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ML)SlydUL-I IIC I IICC:IS UI dUUlU lL'+-, -+0 UI /L-IIF) VVdLCI UtPllvduUll Ull the Ulb position kinetics of trimethadione (TMO) and its only metabolite, dimethadione (DMO), and on the microsomal hepatic drug-oxidizing enzyme activities were investigated in male rats. The DMO/TMO ratios in the serum at 2 hr after intra venous administration of 100 mg/kg TMO were significantly decreased in 48 and 72-hr water-deprived rats, but in 24-hr water-deprived rats, the DMO/TMO ratios were not changed as compared to controls and food restrictions.In the 48 and 72-hr water-deprived rats, contents of cytochrome p-450 and activities of amino pyrine N-demethylase were significantly decreased. On the other hand, activities of aniline hydroxylase in these rats were significantly increased as compared to controls and food restrictions.These results suggest that the effects of water deprivation on drug metabolism not only depend on the time of water deprivation but also vary with the indicator substrate.

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Section: Discussionmentioning

confidence: 96%

“…Recently, the influence of water deprivation on drug disposition kinetics was investigated (1)(2)(3)(4). In humans, dehydration occurs as a result of polyuria or diarrhea, a form of pathologically produced short-term water deprivation.…”

mentioning

confidence: 99%

Influence of Short-Term Water Deprivation on Kinetics of Trimethadione and Its Metabolite in Rats

Tanaka

Kurata

Kuroiwa

et al. 1986

Japanese Journal of Pharmacology

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“…Therefore, it would be expected that the pharmacokinetics and hence the pharmacodynamics of drugs would be altered in water deprivation. Since the first report of the effects of water deprivation on aspirin disposition kinetics [1], water deprivation has been reported [2-4 and references therein] to alter the disposition kinetics of various drugs.…”

Section: Introductionmentioning

confidence: 99%

“…Dehydration occurs by excessive sweating, polyuria, severe diarrhea and hyperthermia [1]. Cancer patients, especially those with gastrointestinal tract cancer, are usually in a dehydrated state.…”

Section: Introductionmentioning

confidence: 99%

Effects of water deprivation for 72 hours on the pharmacokinetics of DA-7867, a new oxazolidinone, in rats

Bae

Kim

Lee

et al. 2006

Biopharm. Drug Dispos.

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The pharmacokinetic parameters of DA-7867 were compared after intravenous and oral administration at a dose of 10 mg/kg in control rats and in rats with water deprivation for 72 h (rat model of dehydration). After intravenous administration in the rat model of dehydration, the Cl(nr) (0.654 versus 0.992 ml/min/kg) and Cl(r) (0.0273 versus 0.0784 ml/min/kg) values were significantly slower than in the controls. The slower Cl(nr) could be due mainly to a significantly smaller total amount of unchanged DA-7867 recovered from the gastrointestinal tract at 24 h (GI(24 h): 5.16% versus 9.21% of intravenous dose) due to impaired liver function in the rat model of dehydration. The slower Cl(r) could be due mainly to a significantly smaller 24 h urinary excretion of unchanged drug (Ae(0-24 h): 4.41% versus 7.75% of intravenous dose) due to urine flow rate-dependent Cl(r) of DA-7867 in the rat model of dehydration. Hence, the Cl was significantly slower in the rat model of dehydration (0.677 versus 1.07 ml/min/kg). After intravenous administration in the rat model of dehydration, the V(ss) of DA-7867 was significantly smaller than in the controls (396 versus 506 ml/kg) due mainly to significantly smaller free (unbound to plasma proteins) fractions of DA-7867 in plasma (6.90% versus 29.2%) in the rat model of dehydration. After oral administration in the rat model of dehydration, the AUC was significantly greater than that in controls (10800 versus 7060 microg min/ml) due mainly to a significantly smaller Ae(0-24 h) than in controls (3.50% and 6.17% of oral dose).

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“…Dehydration can occur by excessive sweating, polyuria, severe diarrhea and hyperthermia [5]. It was reported [6] that in male Sprague-Dawley rats with 72 h water deprivation (rat model of dehydration), the expressions of hepatic CYP1A2, 2B1/2, 2C11 and 3A1/2 were not changed, however, the expression and mRNA level of hepatic CYP2E1 increased compared with the controls.…”

Section: Introductionmentioning

confidence: 98%

Effects of water deprivation on the pharmacokinetics of metformin in rats

Choi

Lee

2007

Biopharm & Drug Disp

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It was reported that metformin was mainly metabolized via hepatic CYP2C11, 2D1 and 3A1/2 in rats, and in a rat model of dehydration, the expressions of hepatic CYP2C11 and 3A1/2 were not changed. Hence, it could be expected that the Cl(nr) of metformin is comparable between two groups of rats if the contribution of CYP2D1 in the rat model of dehydration is not considerable. It was also reported that the timed-interval renal clearance of metformin was dependent on the urine flow rate in rats. In the rat model of dehydration, the 24 h urine output was significantly smaller than in the controls. Hence, the urinary excretion of metformin was expected to be smaller than the controls. The above expectations were proven as follows. After intravenous administration of metformin (100 mg/kg) to the rat model of dehydration, the Cl(nr) were comparable between the two groups of rats. After both intravenous and oral administration of metformin (both 100 mg/kg) to the rat model of dehydration, the 24 h urinary excretion of the drug was significantly smaller than in the controls. After oral administration of metformin to the rat model of dehydration, the AUC was significantly greater (99.2% increase) than the controls.

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Effect of Water Deprivation on Aspirin Disposition Kinetics

Cited by 36 publications

References 33 publications

Influence of Short-Term Water Deprivation on Kinetics of Trimethadione and Its Metabolite in Rats

Influence of Short-Term Water Deprivation on Kinetics of Trimethadione and Its Metabolite in Rats

Effects of water deprivation for 72 hours on the pharmacokinetics of DA-7867, a new oxazolidinone, in rats

Effects of water deprivation on the pharmacokinetics of metformin in rats

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