Effect of Water-Ethanol Extracts of Tarragon (Artimisia Dracunculus L.) and Fermented Black Parsnip (Pastinaca Sativa L.) on Growth and Metastasis of Transplanted Carcinoma of Lewis in Mice

Changes in elemental composition of Lewis carcinoma tumors in mice due to the supply of water–ethanolic extracts of Artemisia dracunculus and Pastinaca sativa

“…Despite the fact that a relative number of animals with metastasis was non-significantly decreased in mice under tarragon 1.2% and 2.0% water-ethanolic extract, the total number of lung metastasis was 1.55 and 1.65 times higher respectively than that of control animals [DERYAGINA et al, 2019] .…”

“…The mice were randomly split into five groups, each containing 9-11 animals: 1) control, mice with transplanted Lewis carcinoma consuming 3.2% ethanol solution; 2) mice supplied with 1.2% water-ethanol extract of tarragon; 3) mice receiving 2.0% water-ethanol extract of tarragon leaves; 4) mice applied with 3.2% water-ethanol extract of 'black parsnip'; 5) mice supplied with 5.6% water-ethanol extract of 'black parsnip' [DERYAGINA et al, 2019] .…”

“…'Blach parsnip' was obtained by parsnip root storage at 70 o C and 95% humidity in a climatic chamber [GOLUBKINA et al, 2019] . In order to produce herb extracts an appropriate amount of 'black parsnip' and tarragon was extracted by 3.2% ethanol at 37 o C during 4 hours.…”

“…Many plants biologically active compounds and products with high antioxidant properties demonstrate their ability in antitumor potential, preventing free radicals formation, changing carcinogen transformation, and affecting DNA reparation, pro-oncogenes expression, proliferation, apoptosis, antitumor immunity system. They may also bound toxic and carcinogenic compounds, inducing their elimination from the body [DERYAGINA et al, 2019;BELITSKY et al, 2016] . Recent studies revealed the antimetastatic effect of parsnip, produced in conditions of prolonged root storage under elevated temperature and humidity (the so-called 'black parsnip') [DERYAGINA et al, 2019;GOLUBKINA et al, 2020] .…”

“…They may also bound toxic and carcinogenic compounds, inducing their elimination from the body [DERYAGINA et al, 2019;BELITSKY et al, 2016] . Recent studies revealed the antimetastatic effect of parsnip, produced in conditions of prolonged root storage under elevated temperature and humidity (the so-called 'black parsnip') [DERYAGINA et al, 2019;GOLUBKINA et al, 2020] .…”