Effect of Weight Loss on Bone Metabolism: Comparison of Vertical Banded Gastroplasty and Medical Intervention

Güney, Engın; Kısakol, Gürcan; Ozgen, Gokhan; Yılmaz, Candeğer; Yilmaz, Rasih; Kabalak, Taylan

doi:10.1381/096089203765887705

Cited by 135 publications

(108 citation statements)

References 21 publications

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“…Indeed, according to epidemiological studies, the correlation between BMI and bone mass remains unclear, while another group of studies found that higher BMI was correlated with high bone mass. Furthermore, adipocytes are important sources of estrogen in women for inhibiting bone resorption [45][46][47]. Thus, we found a correlation between estrogen and BMI in the nonosteoporotic group, although the correlation was weak (r=0.21789); these results support that estrogen levels are involved in the complex relationship between BMI and osteoporosis.…”

Section: Discussionsupporting

confidence: 72%

Relationship Between Polymorphism in Exon 8 of Estrogen Receptor Alpha Gene and Osteoporosis in Saudi Women

Neghery¹,

Daghestani²,

Sherbeeni³

et al. 2018

Eur J Exp Bio

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Objectives: Alternations in the estrogen receptor alpha gene (ERα) play an essential role in osteoporosis etiology. In this study, the relationship between a single nucleotide polymorphism (SNP) in ERα (G2014A) and osteoporosis in Saudi women were investigated. Methods:In this research 40 females with osteoporosis and 41 healthy controls ranging in age from 35 to 75 years were examined. Demographic data were recorded, and blood samples were drawn in plain and in EDTA tubes for estimation of estrogens in the serum and extraction of DNA, respectively. The DNA was used to amplify the fragment of interest carrying the SNP in ERα by polymerase chain reaction (PCR). The PCR product was subjected to DNA sequencing.Results: G2014A was polymorphic in Saudi women. Genotypes and allele frequencies were compared in the osteoporotic and non-osteoporotic groups. Although the genotypes of osteoporotic and non-osteoporotic subjects were significantly different (p=0.0157), the allelic frequency was not significantly different (p=0.519). Estrogen levels significantly differed between osteoporotic and nonosteoporotic subjects (mean ± SD E2: 46.6 ± 30.7 vs. 68.7 ± 47.1 pg/mL, p=0.0143). Importantly, a significant difference in waist-hip ratio in osteoporotic patient and the nonosteoporotic group was detected (0.8 ± 0.1 vs. 0.9 ± 0.0, p=0.0174). Conclusion:Although there was no relationship between G2014A and osteoporosis in Saudi women, this study sheds light on another aspect, such as the significant difference in estrogen levels in these two groups. Furthermore, an advantageous effect of fat on bone mass was observed in the non-osteoporotic group.

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Section: Discussionsupporting

confidence: 72%

Relationship Between Polymorphism in Exon 8 of Estrogen Receptor Alpha Gene and Osteoporosis in Saudi Women

Neghery¹,

Daghestani²,

Sherbeeni³

et al. 2018

Eur J Exp Bio

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“…There is a widely held belief that increasing body weight (and thus higher risk of obesity) is associated with lower risk of osteoporosis (Bell 2004;Coates et al 2004;Guney et al 2003;Radak 2004;Wardlaw 1996). However, we previously found that in quantitative genetic analyses that increasing fat mass (thus higher risk to obesity) is actually associated with decreased bone mass (thus higher risk of osteoporosis) when the latter is adjusted for body weight (Zhao et al 2005).…”

Section: Discussionmentioning

confidence: 89%

Is a gene important for bone resorption a candidate for obesity? An association and linkage study on the RANK (receptor activator of nuclear factor-κB) gene in a large Caucasian sample

et al. 2006

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In light of findings that osteoporosis and obesity may share some common genetic determination and previous reports that RANK (receptor activator of nuclear factor-κB) is expressed in skeletal muscles which are important for energy metabolism, we hypothesize that RANK, a gene essential for osteoclastogenesis, is also important for obesity. In order to test the hypothesis with solid data we first performed a linkage analysis around the RANK gene in 4,102 Caucasian subjects from 434 pedigrees, then we genotyped 19 SNPs in or around the RANK gene. A family-based association test (FBAT) was performed with both a quantitative measure of obesity [fat mass, lean mass, body mass index (BMI), and percentage fat mass (PFM)] and a dichotomously defined obesity phenotype-OB (OB if BMI ≥ 30 kg/m 2 ). In the linkage analysis, an empirical P = 0.004 was achieved at the location of the RANK gene for BMI. Family-based association analysis revealed significant associations of eight SNPs with at least one obesity-related phenotype (P < 0.05). Evidence of association was obtained at SNP10 (P = 0.002) and SNP16 (P = 0.001) with OB; SNP1 with fat mass (P = 0.003); SNP1 (P = 0.003) and SNP7 (P = 0.003) with lean mass; SNP1 (P = 0.002) and SNP7 (P = 0.002) with BMI; SNP1 (P = 0.003), SNP4 (P = 0.007), and SNP7 (P = 0.002) with PFM. In order to deal with the complex multiple testing issues, we performed FBAT multi-marker test (FBAT-MM) to evaluate the association between all the 18 SNPs and each obesity phenotype. The P value is 0.126 for OB, 0.033 for fat mass, 0.021 for lean mass, 0.016 for BMI, and 0.006 for PFM. The haplotype data analyses provide further association evidence. In conclusion, for the first time, our results suggest that RANK is a novel candidate for determination of obesity.

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“…The change in BMD was evident 1 year postsurgery and was associated with the degree of weight reduction [105]. The marked weight loss after long limbbiliopancreatic diversion (BPD-LL) has been associated with decrease in BMD 1 year after surgery [103], RYGB in morbidly obese patients decreases BMC and BMD 1 year postoperatively [106] and, similarly, in a study with follow-up for a year after gastric bypass surgery there was total hip BMD decrease as well as at the lumbar spine [107].…”

Section: Effects Of Bariatric Surgery On Bmdmentioning

confidence: 95%

Obesity and bone metabolism

2018

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The interaction between obesity and bone metabolism is complex. The effects of fat on the skeleton are mediated by both mechanical and biochemical factors. Though obesity is characterized by higher bone mineral density, studies conducted on bone microarchitecture have produced conflicting results. The majority of studies indicate that obesity has a positive effect on skeletal strength, even though most likely the effects are site-dependent and, in fact, obese individuals might be at risk of certain types of fractures. Mechanical loading and higher lean mass are associated with improved outcomes, whereas systemic inflammation, observed especially with abdominal obesity, may exert negative effects. Weight loss interventions likely lead to bone loss over time. Pharmacological treatment options seem to be safe in terms of skeletal health; however, the skeletal effects of bariatric surgery are dependent on the type of surgical procedure. Malabsorptive procedures are associated with higher short-term adverse effects on bone health. In this narrative review, we discuss the effects of obesity and weight loss interventions on skeletal health.

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Effect of Weight Loss on Bone Metabolism: Comparison of Vertical Banded Gastroplasty and Medical Intervention

Cited by 135 publications

References 21 publications

Relationship Between Polymorphism in Exon 8 of Estrogen Receptor Alpha Gene and Osteoporosis in Saudi Women

Relationship Between Polymorphism in Exon 8 of Estrogen Receptor Alpha Gene and Osteoporosis in Saudi Women

Is a gene important for bone resorption a candidate for obesity? An association and linkage study on the RANK (receptor activator of nuclear factor-κB) gene in a large Caucasian sample

Obesity and bone metabolism

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