Effect of weight loss on adipokine levels in obese patients

Rolland, Catherine; Hession, Michelle; Broom, John

doi:10.2147/dmso.s22788

Cited by 35 publications

(23 citation statements)

References 34 publications

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“…However, there is no data yet available that demonstrates a lasting effect of weight loss measures on psoriasis severity/ activity after the intervention. It could be underline that a significant weight loss can lead to significant improvements in circulating levels of leptin, and adiponectin with a possible action and inflammatory state [126] . Improvement of insulin resistance and insulin sensitivity and a significant reduction in systemic inflammation could be obtained by the use of TNF-a inhibitors [118][119][120][121][122][123][124] .…”

Section: Resultsmentioning

confidence: 99%

Non-alcoholic fatty liver disease and psoriasis: So far, so near

Ganzetti

Campanati

Offidani

2015

WJH

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Psoriasis is a chronic inflammatory immune-mediated skin diseases which is frequently associated to comorbidities. Non-alcoholic fatty liver disease (NAFLD) is defined as an excessive accumulation of triglycerides in hepatocytes and includes a wide spectrum of liver conditions ranging from relatively benign steatosis to non-alcoholic steatohepatitis with fatty infiltration and lobular inflammation and to cirrhosis and endstage liver disease. Actually, psoriasis is considered a systemic diseases associated to comorbidities, as metabolic syndrome and NAFLD is seen the hepatic manifestation of the metabolic syndrome. The possible link between psoriasis, obesity and metabolic syndrome, which are known risk factors for NAFLD has been recently documented focusing in the crucial role of the adipose tissue in the development of the inflammatory background sharing by the above entities. According to recent data, patients with psoriasis show a greater prevalence of NAFLD and metabolic syndrome than the general population. Moreover, patients with NAFLD and psoriasis are at higher risk of severe liver fibrosis than those with NAFLD and without psoriasis. The link between these pathological conditions appears to be a chronic low-grade inflammatory status. The aim of this review is to focus on the multiple aspects linking NAFLD and psoriasis, only apparently far diseases. Core tip: The review focuses on the multiple physiopathogenetic aspects of the possible link between psoriasis and non-alcoholic fatty liver disease (NAFLD) emphasizing the most recent scientific data. The importance of the multidisciplinary approach to patients affected by psoriasis is underlined and the therapeutic options to treat concomitant psoriasis and NAFLD is discussed evaluating the risk benefit of both biologic and non-biologic therapies.Ganzetti G, Campanati A, Offidani A. Non-alcoholic fatty liver disease and psoriasis: So far, so near. World J Hepatol 2015; 7(3): 315-326 Available from:

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Section: Resultsmentioning

confidence: 99%

Non-alcoholic fatty liver disease and psoriasis: So far, so near

Ganzetti

Campanati

Offidani

2015

WJH

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“…[46] The weight loss can be even more profound in the wake of very low calorie dieting (VLCD) where fats are restricted more than carbohydrates comparing to LCD. [47] Although the last study does not provide any of the aforementioned characteristics but the body weight, it finds that levels of hormone leptin in VLCD subjects were significantly less than in LCD ones, all obese at the baseline, after 9 months of therapy, which is important for this discussion. Adhering to VLCD for a sufficiently long time makes possible just by itself achieving a full recovery from T2DM.…”

Section: Dyslipidaemiamentioning

confidence: 94%

“…a possible negative impact of processed pork on glucose-insulin metabolism and a possible positive impact of pork intake on waist circumference and HDL-C." We previously noted the success of LCD and VLCD treatments with emphasis on dietary proteins. [46,47] Meat is a major source of proteins; however, it comes with cholesterol. As much as the cholesterol in HDL is desirable, it is undesirable in LDL from the perspective of CVD and T2DM treatment.…”

Section: Cholesterol Profiles and Lipid Lowering Drugsmentioning

confidence: 99%

Data-analytically derived flexible HbA1c thresholds for type 2 diabetes mellitus diagnostic

Stranieri

Yatsko

Jelinek

et al. 2015

AIR

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Glycated haemoglobin (HbA1c) is now more commonly used as an alternative test to the fasting plasma glucose and oral glucose tolerance tests for the identification of Type 2 Diabetes Mellitus (T2DM) because it is easily obtained using the point-of-care technology and represents long-term blood sugar levels. According to WHO guidelines, HbA1c values of 6.5% or above are required for a diagnosis of T2DM. However outcomes of a large number of trials with HbA1c have been inconsistent across the clinical spectrum and further research is required to determine the efficacy of HbA1c testing in identification of T2DM. Medical records from a diabetes screening program in Australia illustrate that many patients could be classified as diabetics if other clinical indicators are included, even though the HbA1c result does not exceed 6.5%. This suggests that a cutoff for the general population of 6.5% may be too simple and miss individuals at risk or with already overt, undiagnosed diabetes. In this study, data mining algorithms have been applied to identify markers that can be used with HbA1c. The results indicate that T2DM is best classified by HbA1c at 6.2% -a cutoff level lower than the currently recommended one, which can be even less, having assumed the threshold flexibility, if additionally to HbA1c being high the rule is conditioned on oxidative stress or inflammation being present, atherogenicity or adiposity being high, or hypertension being diagnosed, etc.

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“…After weight loss, leptin levels decrease [178][179][180], as well TSH and T3 reduces to normal levels [92,93,112]. In starvation conditions, serum leptin levels decrease and thyroid hormones levels are quickly supressed, leading to a consequent reduction in energy expenditure [83].…”

Section: Leptinmentioning

confidence: 99%

“…Not only a minimal weight loss is required but a maximal weigh loss beyond which further improvements in circulating adipokine levels are no longer observed has been suggested [179,182]. The method or diet content by which weigh loss is achieved seems to be less important than the overall weight loss [179,183].…”

Section: Leptinmentioning

confidence: 99%