Effect of weight loss on lactate transporter expression in skeletal muscle of obese subjects

Metz, Lore; Mercier, Jacques; Tremblay, Angelo; Alméras, Natalie; Joanisse, Denis R.

doi:10.1152/japplphysiol.00681.2007

Cited by 14 publications

(9 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…So, the increased lactate and MCT1 levels suggesting an increased lactate transport might be in part associated with the metabolic disease sensitization. On the contrary, obese subjects which present an increased MCT4 protein level in muscle compared to lean subjects exhibited decreased MCT4 levels down to the lean control level when submitted to a weight loss . Concerning MCT1, this study did not describe any change in muscle expression after weight loss.…”

Section: Introductioncontrasting

confidence: 79%

Monocarboxylate transporters: new players in body weight regulation

Carneiro

Pellerin

2015

Obesity Reviews

View full text Add to dashboard Cite

Over the last two decades, several genes have been identified that appear to play a role in the regulation of energy homeostasis and body weight. For a small subset of them, a reduction or an absence of expression confers a resistance to the development of obesity. Recently, a knockin mouse for a member of the monocarboxylate transporter (MCT) family, MCT1, was demonstrated to exhibit a typical phenotype of resistance to diet-induced obesity and a protection from its associated metabolic perturbations. Such findings point out at MCTs as putatively new therapeutic targets in the context of obesity. Here, we will review what is known about MCTs and their possible metabolic roles in different organs and tissues. Based on the description of the phenotype of the MCT1 knockin mouse, we will also provide some insights about their putative roles in weight gain regulation.

show abstract

Section: Introductioncontrasting

confidence: 79%

Monocarboxylate transporters: new players in body weight regulation

Carneiro

Pellerin

2015

Obesity Reviews

View full text Add to dashboard Cite

show abstract

“…In diabetic male Wistar rats, monocarboxylate (88). Although this pattern has also been reported in male diabetic patients with decreased skeletal muscle expression of MCT1 (87), obese individuals did not show differences in muscle MCT1 protein concentrations compared with controls (85). Although MCT1 in human hepatic or intestinal tissues was not directly measured in these studies, these may similarly be affected in diseased conditions.…”

Section: Introductionsupporting

confidence: 48%

Altered Transport and Metabolism of Phenolic Compounds in Obesity and Diabetes: Implications for Functional Food Development and Assessment

Redan

Buhman

Novotny

et al. 2016

Advances in Nutrition

View full text Add to dashboard Cite

Interest in the application of phenolic compounds from the diet or supplements for the prevention of chronic diseases has grown substantially, but the efficacy of such approaches in humans is largely dependent on the bioavailability and metabolism of these compounds. Although food and dietary factors have been the focus of intense investigation, the impact of disease states such as obesity or diabetes on their absorption, metabolism, and eventual efficacy is important to consider. These factors must be understood in order to develop effective strategies that leverage bioactive phenolic compounds for the prevention of chronic disease. The goal of this review is to discuss the inducible metabolic systems that may be influenced by disease states and how these effects impact the bioavailability and metabolism of dietary phenolic compounds. Because current studies generally report that obesity and/or diabetes alter the absorption and excretion of these compounds, this review includes a description of the absorption, conjugation, and excretion pathways for phenolic compounds and how they are potentially altered in disease states. A possible mechanism that will be discussed related to the modulation of phenolic bioavailability and metabolism may be linked to increased inflammatory status from increased amounts of adipose tissue or elevated plasma glucose concentrations. Although more studies are needed, the translation of benefits derived from dietary phenolic compounds to individuals with obesity or diabetes may require the consideration of dosing strategies or be accompanied by adjunct therapies to improve the bioavailability of these compounds.

show abstract

“…Endurance training reduced BMI in type 2 diabetic men in our study as has already been evidenced in previous work [ 18 ] . The reduction in intracellular MCT-4 proteins may be related to the weight loss of the subjects in our study, since Metz et al [ 20 ] demonstrated that MCT-4 proteins were signifi cantly reduced after weight loss in obese subjects. It is noteworthy that there was no diff erence in MCT-1 expression in their subjects before and after weight loss.…”

mentioning

confidence: 56%

Endurance Training Alters Skeletal Muscle MCT Contents in T2DM Men

et al. 2014

View full text Add to dashboard Cite

Patients suffering from type 2 diabetes mellitus (T2DM) often exhibit chronic elevated lactate levels which can promote peripheral insulin resistance by disturbing skeletal muscle insulin-signaling. Monocarboxylate transporter (MCT) proteins transfer lactate molecules through cellular membranes. MCT-1 and MCT-4 are the main protein isoforms expressed in human skeletal muscle, with MCT-1 showing a higher affinity (lower Km) for lactate than MCT-4. T2DM patients have reduced membranous MCT-1 proteins. Consequently, the lactate transport between muscle cells and the circulation as well as within an intracellular lactate shuttle, involving mitochondria (where lactate can be further metabolized), can be negatively affected. This study investigates whether moderate cycling endurance training (3 times per week for 3 months) can change skele-tal muscle MCT contents in T2DM men (n=8, years=56±9, body mass index (BMI)=32±4 kg/m(2)). Protein content analyses (immuno-histochemical stainings) were performed in bio-psies taken from the vastus lateralis muscle. Intracellular MCT-1 proteins were up-regulated (relative increase+89%), while intracellular MCT-4 contents were down-regulated (relative decrease - 41%) following endurance training. Sarcolemmal MCT-1 and MCT-4 did not change. The question of whether the training-induced up-regulation of intracellular MCT-1 leads to an improved lactate transport (and clearance) in T2DM patients requires further research.

show abstract

Effect of weight loss on lactate transporter expression in skeletal muscle of obese subjects

Cited by 14 publications

References 39 publications

Monocarboxylate transporters: new players in body weight regulation

Monocarboxylate transporters: new players in body weight regulation

Altered Transport and Metabolism of Phenolic Compounds in Obesity and Diabetes: Implications for Functional Food Development and Assessment

Endurance Training Alters Skeletal Muscle MCT Contents in T2DM Men

Contact Info

Product

Resources

About