Effect of wet-heparinized suction on the quality of mediastinal solid tumor specimens obtained by endoscopic ultrasound-guided fine-needle aspiration: a retrospective study from a single center

Xu, Bo; Lü, Qian; Fang, Rong; Dai, Xiaojuan; Xu, Huibi; Ding, Xiaobo; Gui, Huawei

doi:10.1186/s12876-023-02845-w

Cited by 2 publications

References 37 publications

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The Heparinized Wet-Suction Technique Enhances Aspiration Quality and Quantity of EUS-FNA for Solid Pancreatic Lesions: A Retrospective Study

Shang,

Han,

Zhu

et al. 2024

Preprint

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Background The optimal suction method for performing endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) on solid pancreatic lesions (SPLs) remains unclear. This study aims to compare the heparinized wet-suction technique (HWST) with the conventional dry-suction technique(DST) for EUS-FNA in SPLs. Methods We conducted a retrospective study on EUS-FNA procedures at a single medical center in China. A total of 105 patients were enrolled who received 3 passes of EUS-FNA with 19-G needles. Sample quantity (including specimen adequacy, maximum intact specimen (MIS) length, and macroscopic visible core (MVC) length), sample quality (including cytology and histology blood contamination), diagnostic accuracy, and adverse events were compared between DST and HWST. Results From January 2021 to April 2024, a total of 105 patients (DST group: n = 50; HWST group: n = 55) were analyzed in this study. The specimen adequacy score was significantly higher with HWST compared to DST in the first pass (P = 0.006), the second pass (P = 0.032), and the combined total of three passes (P = 0.010). HWST produced longer MIS and MVC lengths than DST in the first pass (MIS: P = 0.001; MVC: P < 0.001), the second pass (MIS: P = 0.001; MVC: P = 0.022), and the combined total of three passes (MIS: P = 0.001; MVC: P < 0.001). Compared with DST, HWST yielded a lower blood contamination score in the first pass (cytology: P = 0.002; histology: P = 0.005), the second pass (histology: P = 0.035), and the combined total of three passes (cytology: P = 0.035; histology: P = 0.036). In terms of diagnostic yield, HWST demonstrated a significantly superior histological accuracy in the first pass compared with DST (P = 0.036). Conclusions EUS-FNA with HWST led to significantly higher specimen quantity and quality, improved first-pass histological diagnostic accuracy, and comparable safety to DST. HWST may have a wide range of applications in clinical practice.

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The Heparinized Wet-Suction Technique Enhances Aspiration Quality and Quantity of EUS-FNA for Solid Pancreatic Lesions: A Retrospective Study

Shang,

Han,

Zhu

et al. 2024

Preprint

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Comparing needle types and aspiration techniques in EUS-TA to optimize diagnostic efficacy and specimen quality in patients with pancreatic lesions

Shang,

Han,

et al. 2024

Front. Med.

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PurposeIn solid pancreatic lesions (SPLs), we compared the diagnostic efficacy of a 19G fine-needle aspiration (FNA) needle and a 22G ProCore fine-needle biopsy (FNB) needle, We also compared the specimen quality between the standard suction (SS) technique and heparinized wet-suction (HWS) technique.MethodsAll cases of endoscopic ultrasound-guided tissue acquisition (EUS-TA) by 19G FNA or 22G FNB for SPLs in a single-centre hospital were retrospectively reviewed. The diagnostic yield was compared between the 19G and 22G groups. Univariate and multivariate logistic regression analyses were used to identify optimal factors for a correct histological diagnosis. We also examined tissue integrity, the length of the tissue cores, and the rate of blood cell contamination between the SS and HWS groups.ResultsOne hundred seventy-one and sixty-three patients were included in the comparisons of needle types and suction techniques, respectively. The 19G group had higher histological diagnosis rates compared to the 22G group for the first pass (87.8% vs. 70.4%, p = 0.005), the second pass (82.2% vs. 65.4%, p = 0.012), the first two passes (90.0% vs. 72.8%, p = 0.004), and the final diagnosis (91.1% vs. 79%, p = 0.025). Through macroscopic on-site evaluation, a significantly higher proportion of patients in the 22G group required a third needle pass compared to the 19G group (88.9% vs. 67.8%, p = 0.002). The total procedure time was shorter in the 19G group than in the 22G group (p < 0.001). The HWS group showed superiority over the SS group in terms of the total length of tissue cores (p < 0.001) and the total length of white tissue cores (p = 0.005). The HWS group, compared to the SS group, can enhance the tissue integrity (p = 0.024) and reduce blood cell contamination (p = 0.040) during the first needle pass. There was no significant difference in complication rates between the needle puncture groups (p = 0.770) or the aspiration technique groups (p = 0.654).ConclusionCompared to the 22G FNB needle, endoscopists should consider using the 19G FNA needle when appropriate. Furthermore, the use of the HWS technique for the first pass is recommended to improve specimen quality.

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Effect of wet-heparinized suction on the quality of mediastinal solid tumor specimens obtained by endoscopic ultrasound-guided fine-needle aspiration: a retrospective study from a single center

Cited by 2 publications

References 37 publications

The Heparinized Wet-Suction Technique Enhances Aspiration Quality and Quantity of EUS-FNA for Solid Pancreatic Lesions: A Retrospective Study

The Heparinized Wet-Suction Technique Enhances Aspiration Quality and Quantity of EUS-FNA for Solid Pancreatic Lesions: A Retrospective Study

Comparing needle types and aspiration techniques in EUS-TA to optimize diagnostic efficacy and specimen quality in patients with pancreatic lesions

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