Effect of withdrawal of thyroid hormones versus administration of recombinant human thyroid-stimulating hormone on renal function in thyroid cancer patients

An, Young‐Sil; Lee, Jeonghun; Kim, Hyeung Kyoo; Lee, Su Jin; Yoon, Joon-Kee

doi:10.1038/s41598-023-27455-0

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…[22]. Во взрослой группе пациентов может наблюдаться отягощение хронических заболеваний, таких как артериальная гипертензия, почечная недостаточность, печеночная недостаточность, нарушение липидного обмена, психомоторного состояния, через различные опосредованные механизмы [28][29][30][31]. Безусловно, в педиатрии встречаемость серьезной сопутствующей патологии, способной негативно повлиять на организм за период гипотиреоидного состояния, встречается намного реже.…”

Section: влияние транзиторного гипотиреоза на изменения качества жизн...unclassified

Dynamic Observation in Children and Adolescents Following Management of Differentiated Thyroid Cancer

Reinberg,

Kiyaev,

Chernikov

et al. 2024

Clin Exp Thyroid

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Differentiated thyroid cancer (DTC) is one of the most common malignancies within the endocrine system, with a progressively increasing incidence over recent decades. In the structure of DTC, occurrence in the pediatric age group is relatively rare and is associated with excellent prognoses in terms of disease-specific survival. However, the prevalence of advanced disease in children and the frequency of recurrences present interdisciplinary teams with questions regarding the optimal management approach for such patients, focusing not on achieving disease eradication but preserving and maintaining quality of life. Notably, the presence of oncological pathology, coupled with fluctuations in thyroid hormone levels due to therapeutic interventions, underscores the importance of maintaining psychological and physiological well-being that are affected by the increased frequency of anxiety and depressive symptoms in children and their parents, as well as cognitive and physical functioning. These symptoms may exacerbate against the backdrop of hypothyroidism and directly correlate with TSH levels. To maintain quality of life during the period of dynamic observation and risk group re-stratification, we proposed a method of reduced thyroid hormone doses as an alternative to discontinuing thyroid hormones to assess stimulated thyroglobulin when reaching a threshold TSH level >30 mIU/L. The method was implemented in 2 pediatric patients, showing positive outcomes in terms of absence of hypothyroidism-related complaints, preservation of free thyroid hormone fractions, achievement of adequate target TSH levels, and informative tumor marker indicators. The results of our study underscore the importance of an individualized approach to the management of children with DTC and demonstrate the potential effectiveness of the reduced dose method in maintaining the quality of life of these patients. Further research and clinical observations are necessary for a deeper understanding of the applicability of this method and its impact on longterm outcomes.

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Section: влияние транзиторного гипотиреоза на изменения качества жизн...unclassified

Dynamic Observation in Children and Adolescents Following Management of Differentiated Thyroid Cancer

Reinberg,

Kiyaev,

Chernikov

et al. 2024

Clin Exp Thyroid

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Preparation for radioiodine therapy in patients with differentiated thyroid cancer: a modern perspective (a review)

Reinberg,

Slashchuk,

Trukhin

et al. 2023

Digital Diagnostics

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Thyroid cancer is the most common tumor of the endocrine system, 1-3% of all malignant neoplasms as of 2021. Differentiated forms, papillary and follicular, with a relatively favorable prognosis, are detected in 90% of cases. In recent years, therapy for well-differentiated thyroid cancer (WDTC) has not significantly changed and includes surgical treatment, hormone therapy, radioiodine therapy when indicated, and dynamic monitoring with possible expansion to advanced therapeutic options in cases of disease recurrence. However, there are a range of unresolved issues that are continuing to be actively investigated by new laboratory and instrumental methods. Particularly, one of these issues is the preparation in patients with differentiated thyroid cancer for radioiodine therapy. Radioiodine therapy (RIT) is considered as one of the first targeted therapies for thyroid cancer with a history of over 80 years of use, the main purpose of which is ablation of residual thyroid tissue as well as therapy of distant and/or regional metastases of thyroid cancer. The combination of surgical treatment and subsequent radioiodine therapy provides a favorable prognosis in patients with WDTC, but there is a remaining possibility of insufficient response to radioiodine therapy, which may be associated with multiple factors, including the phase of preparation for RIT. The publication provides a review of the scientific literature on the aspects of preparation of patients with WDTC for radioiodine therapy. The principles of preparation are based on the recommendations of the leading expert societies and studies published in the world practice, as well as known side effects during preparation for radioiodine therapy and thereafter, their impact on patients' quality of life, effectiveness and long-term results of treatment. Materials and Methods Scientific articles and reviews from Medline, Cochrane, and Google Scholar databases were searched by keywords, and recommendations regarding WDTC of the scientific societies were used. Articles in Russian and English with full-text availability were selected; those published after January 2023 were excluded. A systematic evaluation of 130 sources was performed, general trends in the modern approach to patient preparation for radioiodine therapy and current problems were highlighted, and results and conclusions were formulated

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Effect of withdrawal of thyroid hormones versus administration of recombinant human thyroid-stimulating hormone on renal function in thyroid cancer patients

Cited by 2 publications

References 25 publications

Dynamic Observation in Children and Adolescents Following Management of Differentiated Thyroid Cancer

Dynamic Observation in Children and Adolescents Following Management of Differentiated Thyroid Cancer

Preparation for radioiodine therapy in patients with differentiated thyroid cancer: a modern perspective (a review)

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