Effect of Wu Qin Xi exercises on pain and function in people with knee osteoarthritis: A systematic review and meta-analysis

Abstract

BackgroundAs a chronic disease that affects the whole world, there is no definite treatment for knee osteoarthritis (KOA). Wu Qin Xi (WQX) is still in preliminary exploration as a traditional Chinese exercise in the treatment of osteoarthritis of the knee. The purpose of this study was to conduct a meta-analysis of previous studies and to investigate the efficacy of the WQX exercises on pain and function in patients with KOA.MethodsWe searched six databases (Pubmed, Embase, Cochrane Library, Wanfang, CQVIP, and CNKI) for articles on WQX for KOA up to May 10, 2022. Literature search, study selection, data extraction, and quality evaluation were performed by two independent authors. In terms of statistical results, we presented mean differences (MD), 95% CI, and I2 to show heterogeneity, and, based on that, we chose either a random effects model or a fixed effects model.ResultsSeven studies were selected for inclusion in this meta-analysis. The WQX intervention group showed statistical differences for both the total Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score and its various bylaws, the Visual Analogue Score (VAS), and the presence of general functional exercise in the control group. We also demonstrated the clinically meaningful efficacy of WQX treatment by calculating minimum clinical importance difference (MCID) values that met the MCID values on the WOMAC score. A sensitivity analysis was also performed in this study by subgroup analysis for greater heterogeneity, and it was inferred that the difference in follow-up time was a likely source of heterogeneity.ConclusionDespite some limitations, the current study showed a definite effect of WQX in improving pain symptoms and joint function in patients with KOA.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42022332209.

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“…However, after careful reading, it was found that previous systematic reviews have included limited literature as well as indicators. In addition, for the control group, these studies 67 , 68 included studies using different intervention protocols (i.e., strength exercise, physiotherapy, health education, or drugs) or those that did not undergo any intervention. Nevertheless the intervention measures in our study control group were all conventional exercise.…”

The causal relationship between human brain morphometry and knee osteoarthritis: a two-sample Mendelian randomization study

“…This study adhered to the following criteria for instrumental variable (IV) selection ( Wu et al, 2022 ), Each SNP was required to exhibit a significant correlation with 83 cortical and subcortical gray‐matter volumes, surpassing the genome-wide significance threshold (P < 5E-8) ( Scaturro et al, 2023 ). Evaluation of linkage disequilibrium (LD) among SNPs was conducted utilizing European sample data sourced from the 1,000 Genomes Project reference panel, wherein only the most statistically significant SNPs were retained, excluding those exhibiting an R2 value <0.001 within a clumping window of 10,000 kb ( Guo et al, 2022 ). SNPs with a minor allele frequency (MAF) of ≤0.01 were excluded to mitigate potential bias.…”

“…Knee Osteoarthritis (KOA) is a chronic degenerative disease that predominantly affects the articular cartilage of the knee joint, leading to significant pain, disability, and diminished quality of life among affected individuals ( Wu et al, 2022 ; Scaturro et al, 2023 ). As one of the most common forms of arthritis, KOA imposes a substantial burden on individuals and healthcare systems worldwide ( Guo et al, 2022 ). The global prevalence of KOA is increasing, paralleling the aging population and the rising rates of obesity, two of the principal risk factors for the development of this condition ( Du et al, 2023 ; Long et al, 2023 ).…”

Non-pharmacological and non-surgical interventions to manage patients with knee osteoarthritis: An umbrella review 5-year update

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