Effect of Xylopic Acid on Paclitaxel-induced Neuropathic pain in rats

Abstract

Xylopic acid, a diterpenoid isolated from the fruits of Xylopia aethiopica has demonstrated analgesic properties in acute pain models. It was therefore evaluated for its analgesic properties in paclitaxel-induced neuropathic pain, a type of pain difficult to treat clinically. Neuropathic pain was induced in rats by injecting 2 mg kg -1 of paclitaxel on alternative days for four days (days 0, 2, 4 and 6). Paclitaxel-induced cold allodynia, mechanical hyperalgesia and thermal hyperalgesia were measured during pre-paclitaxel administration and on day 16 post-paclitaxel administration. The rats were treated with xylopic acid (10, 30 and 100 mg kg -1 ; groups 1-3), pregabalin (10, 30 and 100 mg kg -1 ; groups 4-6) and vehicle (group 7) daily for 5 days. Pain thresholds were also measured daily for 5 days in the three models. Xylopic acid and pregabalin produced analgesic properties seen as increased paw withdrawal latencies to mechanical and cold water stimuli during the five days treatment. In addition, the two agents significantly (P<0.05) exhibited analgesic properties in the thermal hyperalgesia test. These data suggest that xylopic acid is an effective agent against paclitaxel-induced neuropathic pain.

In VivoAntiplasmodial, Anti-Inflammatory, and Analgesic Properties, and Safety Profile of Root Extracts ofHaematostaphis barteriHook F. (Anacardiaceae)

“…The duration of immersion was recorded and a cut-off time of 10 s was used. The rats were treated with 30, 100, and 300 mg/kg extract and nociception was measured hourly for four hours [ 12 ].…”

Analgesic and Anti-Inflammatory Effect of Ghanaian Medicinal Plants

“…inhibited acetic acid-induced visceral nociception, formalin-induced paw pain, thermally-induced as well as carrageenan-induced mechanical and thermal hyperalgesia [99]. XAE and XA also exhibited anti-hyperalgesic and anti-allodynic properties in vincristine and paclitaxel-induced neuropathic pain [100,101]. Co-administration of XA and pregabalin synergistically reduced paclitaxel induced neuropathic pain without causing any toxicity [102].…”

Antinociceptive effects of an ethanolic extract of Desmodium adscendens: possible involvement of opioidergic, adrenergic, potassium channels and serotoninergic pathways

“…These experiments were carried out as previously described with some modifications [23]. Male Sprague Dawley rats could acclimatize to the behavioural testing environment.…”

“…Baseline measurements of hot and cold thermal stimuli were performed. Neuropathic pain was induced in the rats by intraperitoneal injection of paclitaxel (2 mg/kg) dissolved in distilled water on four alternate days (days 0, 2, 4 and 6) as described by [23,24]. determine the effect of the vehicle, DAE (100 -1000 mg/kg) and pregabalin (10 -100 mg/kg) on thermal hyperalgesia [23].…”