2004
DOI: 10.1016/j.intimp.2003.12.014
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Effect of Y-27632 on release of cytokines from peripheral T cells in asthmatic patients and normal subjects

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Cited by 27 publications
(23 citation statements)
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“…strated that aminofurazan-based ROCK inhibitors suppress the production of IL-6 and TNF-␣ from LPS-stimulated human macrophages. The anti-inflammatory effects of ROCK inhibitors, such as Y-27632 or fasudil, were described previously in several laboratories (Funakoshi et al, 2001;Eto et al, 2002;Segain et al, 2003;Aihara et al, 2004). Our results showed that in macrophages, SB-772077-B and GSK269962A, as members of a distinct class of ROCK inhibitors, suppressed IL-6 mRNA transcription and reduced LPSinduced IL-6 and TNF-␣ protein production.…”
Section: Novel Rho Kinase Inhibitors 95supporting
confidence: 82%
“…strated that aminofurazan-based ROCK inhibitors suppress the production of IL-6 and TNF-␣ from LPS-stimulated human macrophages. The anti-inflammatory effects of ROCK inhibitors, such as Y-27632 or fasudil, were described previously in several laboratories (Funakoshi et al, 2001;Eto et al, 2002;Segain et al, 2003;Aihara et al, 2004). Our results showed that in macrophages, SB-772077-B and GSK269962A, as members of a distinct class of ROCK inhibitors, suppressed IL-6 mRNA transcription and reduced LPSinduced IL-6 and TNF-␣ protein production.…”
Section: Novel Rho Kinase Inhibitors 95supporting
confidence: 82%
“…This reduction in BAL lymphocytes did not translate into changes in BAL IL-13 or IL-5 (Fig.4), perhaps because ILC2s, which do not typically migrate into the airspaces, are the source of the IL-13 and IL-5 (63-65) rather than Th2 cells. Thus, while ROCK does have the capacity to impact eosinophil and lymphocyte activation and migration (8, 39, 40, 66, 67), our results suggest that such events do not contribute to the effects of ROCK1 or ROCK2 insufficiency on OVA-induced AHR (Fig.1) in this model. Dissociations between AHR and airway inflammation have also been observed in asthmatics(68-70).…”
Section: Discussionmentioning
confidence: 61%
“…There are dozens of clinical conditions arising from deficits in mechanosensing, including muscular dystrophy, cardiomyopathies, developmental disorders, and cancer, as reviewed by Jaalouk [54]. While inhibitory molecules have been suggested to address these deficits, such as Y27632 in the treatment of bronchial asthma [55], successful clinical implementation relies on a fully characterized system. In addition, diseased tissue often exhibits different mechanical properties than healthy tissue, which means that any treatment utilizing cells in such areas necessitates a change in physical microenvironment for the therapeutic cell population.…”
Section: Pathfinders: Future Directions For Mechanotransductionmentioning
confidence: 99%