Effect of yokukansan on the behavioral and psychological symptoms of dementia in elderly patients with Alzheimer's disease

Improving the Quality of Postgraduate Education in Traditional Japanese Kampo Medicine for Junior Residents: An Exploratory Survey Conducted in Five Institutions in the Tohoku Area

“…On the other hand, YKS is prescribed for neurosis, insomnia, and irritability in frailty. Many clinical trials have shown that YKS improved the behavioral and psychological symptoms of dementia, such as hallucination, delusion, agitation, and aggression (Iwasaki et al 2005, Mizukami et al 2009, Matsuda et al 2013, Monji et al 2009, Okahara et al 2010. Subsequently, a meta-analysis was performed to examine the effect of YKS on these symptoms (Matsuda et al 2013).…”

Treatment of Dementia-related Symptoms with Japanese Traditional Medicine (Kampo): A Review of Clinical Studies

“…In fact, since 2010, YKS has been listed alongside modern conventional medicine in the Japanese Guidelines for the Management of Dementia by the Japanese Society of Neurology (http://www.neurology-jp.org/guidelinem/nintisyo.html). YKS has a different therapeutic mechanism from that of anti-psychotic agents and improves BPSD and activities of daily living (ADL) without impairing cognitive function or causing extrapyramidal symptoms, which is its greatest advantage in the treatment of elderly patients [5][6][7][8][9][10]. Interestingly, YKS used to be a TCM medicine for symptoms in children such as night cry and sleep terrors.…”

“…Interestingly, YKS used to be a TCM medicine for symptoms in children such as night cry and sleep terrors. Meanwhile, starting in 2005, 5 RCTs have provided support for YKS's efficacy in treating dementia-related symptoms [5,[7][8][9][10] and YKS is now used widely for various symptoms in elderly patients as well as in children in Japan.…”

Systematic Review: Effects of the Kampo Formula Yokukan-San-Ka-Chimpi-Hange on Behavioral and Psychological Symptoms of Dementia

“…Randomized usual-case controlled trials in Japanese dementia patients with behavioral and psychological symptoms were conducted by Iwasaki et al [4], Mizukami et al [5], Monji et al [6], and Okahara et al [7] on the effectiveness of Kampo medicine Yokukan-San (YKS) in treating BPSD. These studies showed that YKS is effective in treating BPSD.…”