Effect of yttrium on calcium-dependent processes in vertebrate myocardium

Abstract

Inoptopic effect of yttrium acetate (Y 3+ ) on myocardium of the marsh frog Rana ridibunda and its effect on ion transport across the inner mitochondrial membrane (IMM) of rat heart was studied. Y 3+ was found to decrease the rate of heart contractions and to stimulate ion transport in the rat heart mitochondria in media with 10 mM glutamate and 2 mM malate. Presence of Y 3+ induced inhibition of energy-dependent Ca 2+ transport into mitochondria, which was expressed as a marked decrease of their swelling in the media containing 125 mM NH 4 NO 3 and Ca 2+ or 25 mM potassium acetate, 100 mM sucrose and Ca 2+ . It is suggested that the Y 3+ -induced decrease in rat muscle contractions is determined not only by direct suppressing effect of Y 3+ on potential-modulated Са 2+ -channels of pacemaker and contractile cardiomyocytes (CM), but also by its indirect effect on Са 2+ -carrier in IMM. The data confirming that Y 3+ activates energy-dependent K + transport catalyzed by mitochondrial uniporter and blocks Ca 2+ -channels in the mitochondrial membrane are important for more complete understanding of mechanisms of the Y 3+ action on vertebrates and human CM.

Threats of Pollutants Derived from Electronic Waste to Marine Bivalves: The Case of the Rare‐Earth Element Yttrium

“…Likewise, in a fish study, Figueiredo et al ( 2018 ) observed that the REE La caused enhanced AChE activity in glass eels, Anguilla anguilla , which the authors linked to La binding to the acetylcholine receptors, replacing calcium. In fact, Y has also been shown to interfere with calcium‐dependent processes in vertebrates (Shemarova et al, 2014 ), which could explain the increase of AChE at particular Y concentrations in mussels.…”

Mechanisms underlying Li+ effects on the myocardium of vertebrates

“…While studying the effect of a series of abiogenic cations (Cd 2+ , La 3+ , Y 3+ ) on cardiac muscle mitochondria, we revealed the dependence between mitochondrial swelling induced by these cations and the reduction in the myocardial contractile characteristics [8][9][10]. Compared with the afore-mentioned cations, lithium ions are less toxic.…”