Effect of Zataria multiflora, Satureja, Oak Fruit Husk, and Jaftex Mouthwash on Treatment of Recurrent Minor Oral Aphthous Stomatitis

Abstract

Context:The use of herbal medications can improve the quality of life and prevent the side effects of chemical drugs. The present narrative review study aimed to assess the efficacy and safety of Zataria multiflora, Satureja, oak fruit husk, and Jaftex herbal mouthwash for the treatment of minor oral aphthous stomatitis. Evidence Acquisition: A literature review was conducted in electronic databases such as PubMed, Web of Science, Scopus, and Google Scholar, as well as Persian databases such as SID, Magiran, and IranMedex from 2000 to 2019, particularly in the last 10 years. The appropriate keywords were searched including "recurrent aphthous stomatitis", "oak tree", "Satureja", "Zataria multiflora", and "Jaftex mouthwash". Results: Six clinical trials were analyzed in the present study. The results showed that Zataria multiflora, Satureja, oak fruit husk, and Jaftex mouthwash have beneficial effects on the treatment of recurrent aphthous stomatitis. The main outcome measures assessed in this study were the duration of the complete healing process, ulcer size, and the level of pain. No side effects were reported in Zataria multiflora, oak fruit husk, and Jaftex mouthwash, but Satureja khuzestanica essential oil revealed a trivial burning at the initial time of application. Conclusions: Reviewing these studies indicated that Zataria multiflora, Satureja, oak fruit husk, and Jaftex mouthwash greatly improved the patients' symptoms by shortening the duration of the complete healing process, reducing ulcer size, and relieving pain. Therefore, these herbal medicines can be used as alternative treatment agents for recurrent aphthous stomatitis. More investigations are required to elucidate the probable mechanism(s) and mode(s) of action of these plants and standardization.