Effect of zearalenone on reproductive parameters and expression of selected testicular genes in mice

Žatecká, Eva; Děd, Lukáš; Elzeinova, Fatima; Kubátová, Alena; Dorosh, Andriy; Margaryan, Hasmik; Dostalova, Pavla; Korenkova, Vlasta; Hošková, Kristýna; Pěknicová, Jana

doi:10.1016/j.reprotox.2014.01.003

Cited by 58 publications

(30 citation statements)

References 45 publications

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“…It is difficult to predict the toxicity of mycotoxin interactions based on their individual toxicities . Moreover, there are few studies evaluating the effect of low toxin doses, which are representative of natural contamination. In most experimental studies the use of moderate to high levels of toxins provides information on the type of interaction, but these doses are not expected in natural contamination and are higher than the maximum limit established in different countries …”

Section: Resultsmentioning

confidence: 99%

Exposure assessment of dogs to mycotoxins through consumption of dry feed

Bissoqui

Frehse

Freire

et al. 2016

J. Sci. Food Agric.

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Section: Resultsmentioning

confidence: 99%

Exposure assessment of dogs to mycotoxins through consumption of dry feed

Bissoqui

Frehse

Freire

et al. 2016

J. Sci. Food Agric.

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“…The binding efficacy of ZEN to ERs in target tissues is 1-10% lower in comparison with E2. α-ZEL demonstrates stronger affinity and β-ZEL -weaker affinity for ERs (Zatecka et al 2014). ZEN is a full agonist of estrogen receptor α (ESR1) and a partial agonist of estrogen receptor β (ESR2) (Zinedine et al 2007).…”

Section: Introductionmentioning

confidence: 99%

The effect of in vivo exposure to zearalenone on cytokine secretion by Th1 and Th2 lymphocytes in porcine Peyer’s patches after in vitro stimulation with LPS

Obremski¹

2014

Polish Journal of Veterinary Sciences

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Most research studies investigating the estrogenic effects of zearalenone (ZEN) focus on the mycotoxin's effect on the reproductive system. Since estrogen receptors are present on various types of immunocompetent cells, ZEN can also modify diverse immune functions. This study analyzed immunocompetent cells isolated from Peyer's patches in the ileum of pigs administered ZEN in the estimated daily dose of 8 μg kg -1 BW (equivalent of 100 μg kg -1 feed per day -1 ). The objective of the study was to determine whether long-term exposure to low ZEN doses below the NOEL threshold leads to changes in the percentages of lymphocyte subpopulations and cytokine secretion by Th1

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“…In vivo and in vitro studies have shown that exposure to ZEA results in decreased steroidogenesis and thus reduction of testosterone produced by Leydig cells. Moreover, the in vivo exposure of male rodents to ZEA caused various fertility-related defects such as an increased number of abnormal spermatozoa, reduced sperm count [182,183], lower pregnancy rate [182], and reduced number of spermatogonia and Sertoli cells [177]. The effect of either ZEA or E2 on ER expression in the testicular tissue and sperm was further conclusively investigated [184].…”

Section: Interaction Of Oestrogen-like Compounds With Ersmentioning

confidence: 99%

Of Oestrogens and Sperm: A Review of the Roles of Oestrogens and Oestrogen Receptors in Male Reproduction

Dostalova

Žatecká

Dvořáková-Hortová

2017

IJMS

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The crucial role that oestrogens play in male reproduction has been generally accepted; however, the exact mechanism of their action is not entirely clear and there is still much more to be clarified. The oestrogen response is mediated through oestrogen receptors, as well as classical oestrogen receptors’ variants, and their specific co-expression plays a critical role. The importance of oestrogen signalling in male fertility is indicated by the adverse effects of selected oestrogen-like compounds, and their interaction with oestrogen receptors was proven to cause pathologies. The aims of this review are to summarise the current knowledge on oestrogen signalling during spermatogenesis and sperm maturation and discuss the available information on oestrogen receptors and their splice variants. An overview is given of species-specific differences including in humans, along with a detailed summary of the methodology outcome, including all the genetically manipulated models available to date. This review provides coherent information on the recently discovered mechanisms of oestrogens’ and oestrogen receptors’ effects and action in both testicular somatic and germ cells, as well as in mature sperm, available for mammals, including humans.

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Effect of zearalenone on reproductive parameters and expression of selected testicular genes in mice

Cited by 58 publications

References 45 publications

Exposure assessment of dogs to mycotoxins through consumption of dry feed

Exposure assessment of dogs to mycotoxins through consumption of dry feed

The effect of in vivo exposure to zearalenone on cytokine secretion by Th1 and Th2 lymphocytes in porcine Peyer’s patches after in vitro stimulation with LPS

Of Oestrogens and Sperm: A Review of the Roles of Oestrogens and Oestrogen Receptors in Male Reproduction

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