Effect of Zhuang Jing Decoction on Learning and Memory Ability in Aging Rats

Abstract

With the average life span of humans on the rise, aging in the world has drawn considerable attentions. The monoamine neurotransmitters and neurotrophic factors in brain areas are involved in learning and memory processes and are an essential part of normal synaptic neurotransmission and plasticity. In the present study, the effect of Zhuang Jing Decoction (ZJD) on the learning and memory ability in aging rats was examined in vivo using Morris water maze. Furthermore, the levels of monoamine neurotransmitters and neurotrophic factors in brain were detected by high-performance liquid chromatography with a fluorescence detector and enzymelinked immunosorbent assay, respectively. These data showed that oral administration with ZJD at the dose of 30 g$kg -1 exerted an improved effect on learning and memory ability in aging rats. The results revealed that ZJD could effectively adjust the monoamine neurotransmitters and neurotrophic factors, restore the balance of the level of monoamine neurotransmitters and neurotrophic factors in brain, and finally attenuate the degeneration of learning and memory ability. These findings suggested that ZJD might be a potential agent as cognitive-enhancing drug in improving learning and memory ability. It may exert through regulating the levels of monoamine neurotransmitters and neurotrophic factors in brain, which demonstrated that ZJD had certain antiaging effects.

Identification of Multi-Target Anti-AD Chemical Constituents From Traditional Chinese Medicine Formulae by Integrating Virtual Screening and In Vitro Validation

“…The purpose of TCM practice is to integrate the combination of herbs under the guidance of a variety of TCM theories according to the specific symptoms of patients. TCM has been widely used in the prevention and treatment of disease for more than 2000 years and there are many Traditional Chinese medicine formulae used to improve cognitive function (Cai et al, 2016). Some chemical components contained in Radix salviae (Zhang et al, 2016), Panacis quinquefolii Radix (Li et al, 2019), Zingiberis rhizoma (Adalier and Parker, 2016), Radix bupleuri (Zeng et al, 2019) and Zingiber officinale Roscoe (Mohd Sahardi and Makpol, 2019) have been used in the study of AD, which is consistent with the predicted results in this paper.…”

Mutations in trpγ, the homologue of TRPC6 autism candidate gene, causes autism-like behavioral deficits in Drosophila

“…The use of Drosophila offered an opportunity to investigate how the defects expressed by trpγ mutants changed with age, finding that some differences with their normal counterpart were maintained (e.g., hyperactivity), whereas others were normalized (e.g., sleep in males). Because aging involves well-conserved metabolic and physiological changes [ 80 , 81 ], this information could be useful to the ASD field since there is limited information on how ASD symptoms change as patients age. Regarding the aging process, decreased expression of TRPC6 [ 82 ] was recently reported in the blood and iPSC-derived neurons of individuals with Alzheimer disorder (AD), suggesting that TRPC6 modulates pathways related to brain aging [ 82 ].…”

Effect of Moxibustion on Testosterone Secretion and Apoptosis of Spermatogenic Cells in Aging Rats

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