Effect of zinc and molybdenum supplementation of the feed concentrate on the storage of copper in the liver of lambs

Schee, Wilke van der; Garretsen, J W; Berg, R. van der

doi:10.1080/01652176.1980.9693763

Cited by 10 publications

(13 citation statements)

References 14 publications

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“…The groups were composed of respectively eight and seven animals each. The groups TM 1, TM 3, TM 5, and TM 6 were studied in 1978; the results have already been published (10). From group TM 1, one sheep was lost by theft; the values of this group are based on seven animals.…”

Section: Resultsmentioning

confidence: 99%

“…The management, the diets, and the analytical procedures are described in detail elsewhere (9,10). In brief, all animals were held in pens and were groupfed.…”

Section: Methods and Proceduresmentioning

confidence: 99%

“…Our conclusion (10) that Zn may be a useful alternative to the somewhat toxic molybdenum as an additive to concentrates in preventing Cu-intoxication was based on a trial with Texel x Friesian milksheep male lambs. Dick (3) In a trial to investigate the influence of different Zn-levels in the feed on the he- …”

Section: Introductionmentioning

confidence: 99%

“…In Sheep, dietary supplementation with zinc can afford protection against the development of Cu-toxicosis by reducing hepatic Cu-concentrations (2,10). A reduction of the hepatic Cu-level can be obtained only by moderately large amounts of dietary Zn.…”

Section: Introductionmentioning

confidence: 99%

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Breed differences in sheep with respect to the interaction between zinc and the accumulation of copper in the liver

Schee

Assem²,

Berg

1983

Veterinary Quarterly

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Section: Resultsmentioning

confidence: 99%

“…The management, the diets, and the analytical procedures are described in detail elsewhere (9,10). In brief, all animals were held in pens and were groupfed.…”

Section: Methods and Proceduresmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Breed differences in sheep with respect to the interaction between zinc and the accumulation of copper in the liver

Schee

Assem²,

Berg

1983

Veterinary Quarterly

Self Cite

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“…Sheep supplemented with 220 ppm, or more effectively 420 ppm zinc, experienced a reduction in liver copper concentrations and a decrease in the severity of liver damage 5 . The addition of 150 and 340 ppm zinc to a ration containing 30 ppm copper, likewise, resulted in a significant reduction in copper accumulation in the liver of sheep 25 . Zinc sulphate, when added to the drinking water to supply a dose of 250-300 mg/ sheep/day for 6 consecutive weeks, gave excellent results in preventing enzootic icterus (G Bath, Faculty of Veterinary Science, University of Pretoria, pers comm., 1993).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of a commercially available molybdate formulation and zinc oxide boluses in preventing hepatic copper accumulation and thus enzootic icterus in sheep

Botha¹,

Shakespeare²,

Gehring³

et al. 2001

J. S. Afr. Vet. Assoc.

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The efficacy of a molybdate formulation and a zinc oxide bolus as prophylactic agents for enzootic icterus was evaluated in sheep. Before copper loading, liver biopsies were performed on 12 male, 6-month-old, Mutton Merino sheep to determine hepatic copper (Cu) and zinc (Zn) concentrations. The animals were restrictively randomised according to liver copper concentrations to 3 treatment groups (n = 4) to achieve similar mean liver copper concentrations per group. All sheep received 4 m /kg of a 0.5 %aqueous solution of CuSO4Â·5H2O intraruminally 7 days per week for 10 weeks. On Day 0 the sheep in the Mo-group were injected subcutaneously with 42 mg molybdenum (Mo) contained in a commercial molybdate formulation. The animals in the Zn-group each received a zinc oxide bolus, containing 43 g zinc oxide, via a rumen cannula. Treatment was repeated on Day 42. Four animals served as untreated controls. Urinary copper excretion, plasma copper concentration, haematocrit and glutamate dehydrogenase (GLDH) activity were determined throughout the trial. The animals were sacrificed after 10 weeks and liver samples were submitted for histopathological examination. Liver and kidney copper and zinc concentrations were determined. Neither the molybdate treatment nor the zinc oxide boluses prevented hepatic copper accumulation. The urinary copper excretion, plasma copper concentration, haematocrit and GLDH activity were not significantly different (P > 0.05) from the controls.

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Effects of different levels of dietary sulfur and molybdenum on concentrations of copper and other elements in plasma and liver of lambs fed palm kernel cake diets

2011

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A 6-month experiment with nine dietary treatments was conducted to determine amounts of S plus Mo supplements required to maintain normal hepatic concentrations of Cu and Mo and to prevent chronic Cu toxicity in lambs fed palm kernel cake (PKC) diets. All diets consisted of PKC supplemented with minerals and vitamins, and with appropriate amounts per kg DM of S (level 0 or level 1 ¼ 1 g) as sodium sulfate and/or Mo (level 0; level 1 ¼ 4 mg; level 2 ¼ 8 mg; level 3 ¼ 16 mg; level 4 ¼ 32 mg) as ammonium molybdate to form treatments S0Mo1, S0Mo2, S0Mo3, S0Mo4, S1Mo0, S1Mo1, S1Mo2, S1Mo3 and S1Mo4.There was no effect (P.0·05) of dietary treatments on the growth performance of the lambs. The dietary supplement of 1 g S plus 8 mg Mo per kg dietary DM (treatment S1Mo2) prevented accumulation of Cu in the liver without elevation of the concentration of Mo (P.0·05). The treatments S0Mo1, S0Mo2 and S0Mo3 increased (P,0·05) hepatic Cu concentrations from 376 mg/g DM to between 1090 and 1294 mg/g DM. Also, the treatments S1Mo3 and S1Mo4 resulted in higher (P, 0·05) hepatic Mo concentrations compared with the treatment S1Mo0. It was concluded that the dietary supplement of 1 g S plus 8 mg Mo/kg PKC DM added to the PKC used is sufficient to maintain normal hepatic concentrations of Cu and Mo and to prevent chronic Cu toxicity in sheep fed diets containing any amount of PKC.

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Effect of zinc and molybdenum supplementation of the feed concentrate on the storage of copper in the liver of lambs

Abstract: SUMMARYDuring a 98-day trial, eight groups of eight male weanling Texel x Friesian milk sheep lambs were fed the same hay and concentrates, the latter differing only in the contents of Cu, Zn, and Mo.

Cited by 10 publications

References 14 publications

Breed differences in sheep with respect to the interaction between zinc and the accumulation of copper in the liver

Breed differences in sheep with respect to the interaction between zinc and the accumulation of copper in the liver

Evaluation of a commercially available molybdate formulation and zinc oxide boluses in preventing hepatic copper accumulation and thus enzootic icterus in sheep

Effects of different levels of dietary sulfur and molybdenum on concentrations of copper and other elements in plasma and liver of lambs fed palm kernel cake diets

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